Shichang Liu

AgentLeak: Cloning Stronger LLM Agent Capabilities onto Weaker Agents Beyond Skill Stealing

Xiaoting Lyu, Yuhong Wu, Yufei Han, Shichang Liu et autres

Large language model (LLM) agents increasingly achieve long-horizon tasks by combining foundation models with explicit skills and implicit procedural knowledge acquired through execution. The resulting task-solving capabilities have become valuable proprietary assets, raising a new security question: can a substantially weaker attacker-controlled …

Sprayable nanocomposite hydrogel dressing enriched with cerium oxide nanoparticles for accelerated wound healing and infection control

Shichang Liu, Samuel Margolis, Yucheng Zhang, Shaolei Wang et autres

Abstract Wound healing remains a critical challenge in medical treatment, particularly for infected and complex wounds. This study introduces a novel sprayable nanocomposite hydrogel dressing (SA/CaCl 2 /CeO 2 , SCC) that demonstrates exceptional potential for accelerated wound healing and bacterial infection …

cn, us (code pays fourni par la source)

Detection of tumor immunity-related ENPP1 using AIE-active probe QM-AMP

Yuwei Wang, Ting Yang, Shichang Liu, Haojian Yang et autres

Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), a crucial biomarker on the surface of tumor cells, plays a significant role in immune suppression and cancer metastasis. In this study, we successfully developed a novel amphiphilic fluorescent probe, QM-AMP, based on quinoline-malononitrile aggregation-induced emission (AIE) characteristics, …

cn (code pays fourni par la source)

Thiolated nanomaterials for bone tissue engineering: synthesis, mechanisms, and applications

Yining Gong, Bin Zhu, Yazhong Bu, Baoji Du et autres

Abstract Owing to their unique biological effects and physicochemical properties, nanomaterials have garnered substantial attention in the field of bone tissue engineering (BTE), targeting the repair and restoration of impaired bone tissue. In recent years, strategies for the design and optimization of …

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Bone-Adhesive Peptide Hydrogel Loaded with Cisplatin for Postoperative Treatment of Osteosarcoma

Taotao Huo, Junxian Miu, Ziyi Wang, Xiaoyu Shan et autres

The inhibition of residual tumor recurrence while repairing bone defects poses a challenging issue for postoperative osteosarcoma treatment. Here, we develop a self-assembling peptide hydrogel (GelA) for the targeted delivery of cisplatin (CDDP), aiming to integrate postoperative tumor inhibition with bone defect …

cn (code pays fourni par la source)

Redesigned Pathway for De Novo Synthesis of Vanillin and Co-conversion of Multiple Renewable Substrates in Saccharomyces cerevisiae

Xin Xin, Danfeng Liu, Shichang Liu, Zhiyuan Liu et autres

High Resolution Image Download MS PowerPoint Slide Vanillin, known as the “queen of flavors”, is an extensively used and important aromatic compound with multiple functions, including aldehyde, ether, and hydroxyl. Converting lignocellulosic biomass-derived substrates to natural vanillin is sustainable and economical through …

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Enzyme‐Mediated In Situ Self‐Assembly AIE Probes: Mapping the Distribution of Acetylcholinesterase in Aging Mice Brain

Zhirong Zhu, Shanshan Hu, Youheng Zhang, Shichang Liu et autres

Abstract Acetylcholinesterase (AChE) exhibits profound association with the underlying pathological mechanisms of aging‐related disorders. However, revealing the spatial distribution of AChE among whole‐brain remains an uncharted territory, posing a substantial challenge. Herein, a dual regulation strategy to obtain an aggregation‐induced emission (AIE)‐activable …

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Enhancement of Bone Repair in Diabetic Rats with Metformin‐Modified Silicified Collagen Scaffolds (Adv. Healthcare Mater. 3/2025)

Yi‐Rong Wang, Xiaoxia Zhang, Xinhua Yin, Ming Yang et autres

Bionic Collagen Materials In article 2401430, Yi-Rong Wang, Shi-Chang Liu, and co-workers used a biomimetic silicification principle to prepare a metformin-modified silicified collagen material. This material has been shown to promote mitochondrial autophagy by regulating the AMPK/m-TOR signaling pathway, reducing reactive oxygen …

Effects of different storage temperatures on the quality and metabolome of maize with high moisture content

Yan Zhao, Tianjie Qi, Chaoyue Cui, Xuguang Liu et autres

Storage temperature and moisture content are important factors affecting the quality of maize storage. This research investigated the impact of varying temperatures on the quality and metabolite composition of high moisture maize during the storage process. Results showed that as the storage …

cn (code pays fourni par la source)

An azo substituted quinoline‐malononitrile enzyme‐activable aggregation‐induced emission nanoprobe for hypoxia imaging

Zhirong Zhu, Shichang Liu, Xupeng Wu, Qianqian Yu et autres

Abstract The development of efficient aggregation‐induced emission (AIE) active probes is crucial for disease diagnosis, particularly for tumors and cardiovascular diseases. Current AIE‐active probes primarily focus on improving their water solubility to resist aggregation, thereby achieving an initial fluorescence‐off state. However, the …

cn (code pays fourni par la source)

Enhancement of Bone Repair in Diabetic Rats with Metformin‐Modified Silicified Collagen Scaffolds

Yi‐Rong Wang, Xiaoxia Zhang, Xinhua Yin, Ming Yang et autres

Regenerating bone defects in diabetic rats presents a significant challenge due to the detrimental effects of reactive oxygen species and impaired autophagy on bone healing. To address these issues, a metformin-modified biomimetic silicified collagen scaffold is developed utilizing the principles of biomimetic …

cn (code pays fourni par la source)

HRDC challenge: a public benchmark for hypertension and hypertensive retinopathy classification from fundus images

Bo Qian, Xiangning Wang, Zhouyu Guan, Dawei Yang et autres

cn, hk, ca, au, us, sg, ch (code pays fourni par la source)