Yuwen Zhang

Achieving optimal GaN/SiC interfacial thermal conductance via ultrathin alloy interlayers for high-power device cooling

Yuwen Zhang, Zhipeng Tang, Tao Ouyang, Wu Li

Efficient heat dissipation across GaN/SiC interfaces is critical for the reliability of high-power devices, yet their interfacial thermal transport behavior remains insufficiently understood. Here, using a high-fidelity machine-learning interatomic potential, we perform systematic nonequilibrium molecular dynamics simulations to quantify and engineer the …

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A Layered-Responsive DNA Tetrahedral Nanomachine for Precise Cancer Cell Imaging and Selective cGAS-STING Signaling Activation

Yuwen Zhang, Tong Zhang, Xiao-Qiong Li, Bin Kang et autres

The dual challenges of accurately imaging cancer cells and selectively activating immune signaling pathways require innovative DNA nanomachines with targeted recognition and multistimulus response capabilities. In this study, we developed a dual tetrahedral DNA nanomachine (DTDN) with layered responsiveness, which integrated a …

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MultiSite Assembly of Gateway Induced Clones (MAGIC): a flexible cloning toolbox for use in vertebrate model systems

William B. Gillespie, Yuwen Zhang, Oscar E. Ruiz, Juan Cerda et autres

Here, we present MultiSite Assembly of Gateway Induced Clones (MAGIC), which leverages Gateway-based recombinatorial cloning technology for rapid, modular assembly of plasmids to facilitate transgenesis in cells and vertebrate animal models. The MAGIC collection of plasmids spans a range of in vitro …

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GPUMD 4.0: A high‐performance molecular dynamics package for versatile materials simulations with machine‐learned potentials

Ke Wei Xu, Hangyu Bu, Shuning Pan, Eric Lindgren et autres

Abstract This paper provides a comprehensive overview of the latest stable release of the graphics processing units molecular dynamics (GPUMD) package, GPUMD 4.0. We begin with a brief review of its development history, starting from the initial version. We then discuss the …

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Latest advances and prospects in the pathogenesis, animal models, and vaccine research of severe fever with thrombocytopenia syndrome virus

Chenghao Chen, Jiaxuan Li, Yuhe Zhou, Yuwen Zhang et autres

Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), a tick-borne phlebovirus first identified in China, causes severe illness characterized by high fever, thrombocytopenia, leukopenia, and, in some cases, multi-organ failure and death. With mortality rates ranging from 5% to 30% in endemic regions, …

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Multicrossmodal Automated Agent for Integrating Diverse Materials Science Data

Adib Bazgir, Rama chandra Praneeth Madugula, Yuwen Zhang

We introduce a multicrossmodal LLM-agent framework motivated by the growing volume and diversity of materials-science data ranging from high-resolution microscopy and dynamic simulation videos to tabular experiment logs and sprawling literature archives. While recent AI efforts have accelerated individual tasks such as …

Su1292: DEVELOPMENT AND IMAGING OF BIOLUMINESCENT HUMAN INTESTINAL ORGANOIDS

Prisca C. Obidike, Chioma Moneme, Bryan Hogg, Yuwen Zhang et autres

Inter-kingdom interactions and environmental influences on the oral microbiome in severe early childhood caries

Lingjia Weng, Yuqi Cui, Wenting Jian, Yuwen Zhang et autres

ABSTRACT Dental caries arise from intricate interactions among oral microorganisms, impacting ecological stability and disease progression. In this study, we aimed to investigate the microbial diversity and inter-kingdom interactions in severe early childhood caries (S-ECC) and assess the influence of environmental factors …

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Population genomics of sika deer reveals recent speciation and genetic selective signatures during evolution and domestication

Huamiao Liu, Bo Zhu, Tianjiao Wang, Yimeng Dong et autres

BACKGROUND: Population genomic analysis can reconstruct the phylogenetic relationship and demographic history, and identify genomic selective signatures of a species. To date, fundamental aspects of population genomic analyses, such as intraspecies taxonomy, evolutionary history, and adaptive evolution, of sika deer have not …

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Characteristics of spatial and temporal non-stationarity of groundwater storage in different basins of China and its driving mechanisms

Feng Yan, Yuwen Zhang, Xinpeng Wang, Zheng Quan Xu et autres

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Effect of SY009, a novel SGLT1 inhibitor, on the plasma metabolome and bile acids in patients with type 2 diabetes mellitus

Haoyi Yang, Yuwen Zhang, Yuxin Hong, Yuning Zhu et autres

Context: As a novel SGLT1 inhibitor, SY-009 has been preliminarily confirmed in a phase Ib clinical study for its ability to reduce postprandial blood glucose in patients with type 2 diabetes mellitus (T2DM). However, the effects of SY-009 on human plasma metabolomics …

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Uncovering a cryptic Streptococcus suis endemic post-outbreak: Evidence of host switching to humans

Shuirong Zhu, Shengkai Li, Beibei Wu, Zhangnv Yang et autres

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