Haiyang Wang

An in silico transcription factor perturbation simulator uncovers diverse genetic architectures of brain disorders

Haiyang Wang, Qingyu Li, Ying Zhu

Determining mechanisms and developing treatments for brain disorders with complex genetic architectures remains a challenge. We developed TFdisc, an in silico transcription factor (TF) perturbation simulator that uses wild-type single-cell RNA sequencing data to emulate corresponding post-TF perturbations. TFdisc’s accuracy in reconstructing …

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Genomic sequence evolution underlying human neocortical interareal diversification

Wei He, Weizhen Hou, Chengyong Jiang, Xi Zhang et autres

BACKGROUND: Neocortical expansion and diversification in primates, especially humans, underpin advanced cognitive abilities, yet the molecular and cellular bases of neocortical area specification remain incompletely understood. RESULTS: Here, we perform an integrative multimodal analysis combining single-nucleus multiomic and spatial transcriptomic sequencing, morphological …

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Incremental learning-enhanced LSTM for spoofing detection in GNSS signals

Yan Wang, Xiaofei Chen, Decai Zou, Xiaochun Lu et autres

With the widespread application of Global Navigation Satellite Systems (GNSS), spoofing interference has emerged as a major threat to system security due to its high level of concealment. Traditional static learning models face performance degradation issues in long temporal sequences, making it …

cn (code pays fourni par la source)

From Black Hole to Galaxy: Neural Operator: Framework for Accretion and Feedback Dynamics

Nihaal Bhojwani, Chaoran Wang, Haiyang Wang, Chang Sun et autres

Modeling how supermassive black holes co-evolve with their host galaxies is notoriously hard because the relevant physics spans nine orders of magnitude in scale-from milliparsecs to megaparsecs--making end-to-end first-principles simulation infeasible. To characterize the feedback from the small scales, existing methods employ …

Refining Approaches to Fibrosis Control in Kidney Transplant Recipients

Haiyang Wang, Tao Liu, Mingyang Li

cn (code pays fourni par la source)

Blood Cells, Endothelial Cells, and Circulating Extracellular Vesicles Induce Procoagulant Activity by Phosphatidylserine Exposure in Chronic Coronary Artery Disease Patients with In-stent Restenosis after Percutaneous Coronary Intervention

Dongxia Tong, Lu Kong, Bin Song, Wu Wei et autres

AIMS: In-stent restenosis (ISR) is a significant limitation of coronary stent implantation, but the exact mechanism of ISR remains unclear. Patients after percutaneous coronary intervention (PCI) are in a hypercoagulable state; however, there is less information on its association with chronic coronary …

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Effects of carboxymethyl modification on physicochemical properties, structure of fenugreek polysaccharide and its capabilities of aroma enhancement and moisture retention in cigarettes

Lin Jiang, Haiyang Wang, Zizhen Chen, Tao Wu et autres

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Counterbalancing O‐GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress

Mingshuo Shao, Yi Wu, Haiyang Wang, Chenchun Zhang et autres

Abstract Acute stressors, significant risk factors for mood disorders, increase anxiety and reduce reward sensitivity. However, the underlying neuroadaptive mechanisms remain unclear. Here, it is shown that acute restraint stress upregulates Signal Transducer and Activator of Transcription 3 (STAT3) signaling and O‐GlcNAcylation …

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Thyroid function and viability after larynx-trachea-thyroid allotransplantation: a case series

Liu Wang, Mailudan Ainiwaer, Qing Shao, Feng Qiu et autres

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RLJP: Legal Judgment Prediction via First-Order Logic Rule-enhanced with Large Language Models

Yue Zhang, Zhiliang Tian, Shicheng Zhou, Haiyang Wang et autres

Legal Judgment Prediction (LJP) is a pivotal task in legal AI. Existing semantic-enhanced LJP models integrate judicial precedents and legal knowledge for high performance. But they neglect legal reasoning logic, a critical component of legal judgments requiring rigorous logical analysis. Although some …

0053 Multi-omics Studies of Upper Airway Muscles Advance Obstructive Sleep Apnea Pathogenesis Insights

Xiaoru Sun, Haiyang Wang, Shixi Liu, Jian Zou

Abstract Introduction Obstructive sleep apnea (OSA) is a common sleep disorder characterized by upper airway collapse during sleep, with unclear molecular mechanisms. This study represents the first multi-omics investigation of upper airway muscles (UAMs) from OSA patients, integrating transcriptomics, proteomics, phosphoproteomics, and …

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Sa1185: TARGETED MCL1 COMBINED WITH PALBOCICLIB ELIMINATES SENESCENT COLORECTAL CANCER CELLS

Haiyang Wang, Li Liu, Zhining Fan