Genomic sequence evolution underlying human neocortical interareal diversification
Rattachement africain : cn, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Neocortical expansion and diversification in primates, especially humans, underpin advanced cognitive abilities, yet the molecular and cellular bases of neocortical area specification remain incompletely understood. RESULTS: Here, we perform an integrative multimodal analysis combining single-nucleus multiomic and spatial transcriptomic sequencing, morphological and electrophysiological profiling, and secondary comparisons across humans, macaques, and mice. We uncovered enhanced area-specific cellular diversification in primates, including distinct upper-layer projection neuron and interneuron subtypes, increased electrophysiological and morphological complexity, and enriched cell connectivity and crosstalk. Notably, this increased interareal heterogeneity coincides with the expansion of evolutionarily young DNA sequences in primates, especially Hominoidea, which are enriched for transposable elements (TEs). We deduce that TEs are likely to contribute to areal specification by acting as cis-regulatory elements and by diversifying the transcriptome. Specifically, TEs harbor evolutionarily novel area-specific transcription factor binding sites for species- and/or area-specific transcription factors in human genome, correlating with the expression of diverse gene biotypes across neocortical areas. Furthermore, our findings reveal that the expression of TE transcripts distinguishes the upper-layer neurons in the frontal cortex, likely enhancing cellular diversification through mechanisms beyond protein-coding gene expression. CONCLUSIONS: These findings illuminate genomic and cellular mechanisms contributing to human neocortical reorganization during evolution, providing insights into the molecular underpinnings of primate brain specialization.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Genomic sequence evolution underlying human neocortical interareal diversification
- Date Crossref
- 29/06/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Huashan Hospital pays non établi dans la noticeÉtablissement de santé
-
Frontiers Center for Brain Science of the Ministry of Education pays non établi dans la noticeStructure de recherche
-
Eye & ENT Hospital of Fudan University Department of Neurosurgery pays non établi dans la noticeÉtablissement de santé
-
Yale University pays non établi dans la noticeUniversité ou école supérieure
-
Yale School of Medicine Department of Neuroscience pays non établi dans la noticeUniversité ou école supérieure
-
Tianqiao and Chrissy Chen Institute Clinical Translational Research Center pays non établi dans la noticeStructure de recherche
Huashan Hospital, Frontiers Center for Brain Science of the Ministry of Education et Department of Neurosurgery — Eye & ENT Hospital of Fudan University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.