Elena Zamorano-Domínguez

A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance

Vasiliki Liaki, Sara Barrambana, Myrto Kostopoulou, Carmen G. Lechuga et autres

Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest cancer survival rates. Recent studies using RAS inhibitors have opened the door to more efficacious therapies although their beneficial effect is still limited mainly due to the rapid appearance of tumor resistance. Here, …

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High-fat diet imprints a macrophage-tumor CAMP-P2RX7 axis driving pancreatic cancer initiation, plasticity and metastasis

Ana Galván-del-Rey, Juan Carlos López-Gil, Livia Archibugi, Sonia Alcala et autres

Abstract High-fat diet (HFD) and obesity are increasingly recognized as risk factors of pancreatic ductal adenocarcinoma (PDAC), yet the mechanisms by which dietary fat contribute to oncogenic transformation remain elusive. Using an inducible acinar-specific Kras G12V / Trp53 -loss genetically-engineered mouse model …

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RETRACTED: A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance

Vasiliki Liaki, Sara Barrambana, Myrto Kostopoulou, Carmen G. Lechuga et autres

Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest cancer survival rates. Recent studies using RAS inhibitors have opened the door to more efficacious therapies, although their beneficial effect is still limited mainly due to the rapid appearance of tumor resistance. Here, …

cu, es, fr, bg, it (code pays fourni par la source)

Complete deletion of Kras in adult mice: a genetic model

Elena Zamorano-Domínguez, Lucía Morales-Cacho, Rafael Barrero, Silvia Jiménez et autres

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Systemic Kras ablation disrupts myeloid cell homeostasis in adult mice

Elena Zamorano-Domínguez, Lucía Morales-Cacho, Rafael Barrero, Silvia Jiménez-Parrado et autres

The KRAS oncogene has been associated with many types of cancer, including pancreatic, lung, and colorectal. For decades, its gene products were thought to be undruggable. However, during the last decade, a large battery of KRAS inhibitors selective against specific mutations (KRAS …

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Navigating the complexities of pancreatic ductal adenocarcinoma: A review on therapeutic models and RAS inhibitors

Sara Barrambana, Elena Zamorano-Domínguez, Vasiliki Liaki, Carmen E. Guerra

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Complete deletion of Kras in adult mice: a genetic model

Elena Zamorano-Domínguez, Lucía Morales Cacho, Silvia Jiménez Parrado, Francisca Mulero Aniorte et autres

es (code pays fourni par la source)