Sara Barrambana

A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance

Vasiliki Liaki, Sara Barrambana, Myrto Kostopoulou, Carmen G. Lechuga et autres

Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest cancer survival rates. Recent studies using RAS inhibitors have opened the door to more efficacious therapies although their beneficial effect is still limited mainly due to the rapid appearance of tumor resistance. Here, …

es, cu, fr, it, bg (code pays fourni par la source)

Abstract 4698: Quantifying ongoing chromosomal instability using single-cell whole-genome sequencing

Bárbara Hernando, Blas Chaves-Urbano, Maria Escobar-Rey, Alice Cádiz et autres

Abstract Chromosomal instability (CIN) describes the set of processes that generate numerical and structural DNA changes that typically operate during tumourigenesis. High-resolution readouts of DNA changes can be achieved using whole-genome sequencing (WGS) and the distinct patterns of copy number aberrations seen …

es (code pays fourni par la source)

RETRACTED: A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance

Vasiliki Liaki, Sara Barrambana, Myrto Kostopoulou, Carmen G. Lechuga et autres

Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest cancer survival rates. Recent studies using RAS inhibitors have opened the door to more efficacious therapies, although their beneficial effect is still limited mainly due to the rapid appearance of tumor resistance. Here, …

cu, es, fr, bg, it (code pays fourni par la source)

Tracking ongoing chromosomal instability using single-cell whole-genome sequencing

Bárbara Hernando, Blas Chaves-Urbano, Maria Escobar-Rey, Marina Torres Lázaro et autres

Abstract Chromosomal instability (CIN) generates aneuploid genomes that are characteristic of most cancers. While bulk genome sequencing reveals historical CIN, it lacks the resolution to identify ongoing CIN that actively shapes genome evolution. Here, we present a computational framework that leverages single-cell …

es, us, lk (code pays fourni par la source)

Novel therapeutic strategies targeting KRAS driven pancreatic ductal adenocarcinoma: patients profiling

Sara Barrambana, Vasiliki Liaki, Carmen G. Lechuga, José Carbonell‐Caballero et autres

es, us (code pays fourni par la source)

Systemic Kras ablation disrupts myeloid cell homeostasis in adult mice

Elena Zamorano-Domínguez, Lucía Morales-Cacho, Rafael Barrero, Silvia Jiménez-Parrado et autres

The KRAS oncogene has been associated with many types of cancer, including pancreatic, lung, and colorectal. For decades, its gene products were thought to be undruggable. However, during the last decade, a large battery of KRAS inhibitors selective against specific mutations (KRAS …

es, us, ch, cu, ar (code pays fourni par la source)

Navigating the complexities of pancreatic ductal adenocarcinoma: A review on therapeutic models and RAS inhibitors

Sara Barrambana, Elena Zamorano-Domínguez, Vasiliki Liaki, Carmen Guerra

us, es (code pays fourni par la source)

Novel therapeutic strategies targeting KRAS driven pancreatic ductal adenocarcinoma

Sara Barrambana, Vasiliki Liaki, Teresa Laguna, Silvia Jiménez Parrado et autres

es (code pays fourni par la source)

Saliva Protein Composition Relates with Interindividual Variations in Bread Sensory Ratings

Elsa Lamy, V. S. Santos, Sara Barrambana, Carla Simões et autres

Abstract Sensory perception of starch‐based products associates with salivary α‐amylase enzymatic activity. Besides this, other proteins relate to taste sensitivity and oral food processing. As such, the participation of different salivary constituents in starch‐rich food's sensory evaluation cannot be excluded. This study …

pt (code pays fourni par la source)

Mitochondrial dynamics in thyroid cancer: unravelling the role of DRP1

Sara Barrambana

Rien dans la vie n'est à caindre, tout doit être compris.C'est maintenant le moment de comprendre d'avantage, afin de craindre moins."