Accès ouvert
2026
article
OpenAlex
Karoline Kondrup, Laura Iisager, Paul Vinu Salachan, Maibritt Nørgaard et autres
BACKGROUND: Metastatic castration-resistant prostate cancer (mCRPC) remains a lethal disease with few biomarkers to inform treatment selection or patient prognosis. Methylation profiles of plasma circulating tumour DNA (ctDNA) accurately reflect tumour methylomes and may reveal novel biomarkers of mCRPC. METHODS: To establish …
dk, gb
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Karoline Kondrup, Mads Ryø Jochumsen, Laura Iisager, Paul V. Salachan et autres
Abstract Background: Metastatic prostate cancer (mPC) is associated with high mortality. Newly diagnosed PC patients suspected of metastasis can undergo imaging-based primary tumor staging by PSMA PET/CT. Accurate staging is crucial for treatment selection, as localized PC may be cured by surgery …
dk
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Laura Iisager, Cecilie Lindgaard, Johanne Ahrenfeldt, Jesper Huitfeld Jespersen et autres
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is characterized by marked epigenetic dysregulation, contributing to aberrant gene expression and tumor progression. To expand current knowledge on genome-wide methylation patterns in ccRCC, we performed Methylated DNA Immunoprecipitation sequencing (MeDIP-seq) on tumor samples from …
dk
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Ludvig Renbo Olsen, Denis Odinokov, Jakob Qvortrup Holsting, Karoline Kondrup et autres
The fragmentation patterns of whole genome sequenced cell-free DNA are promising features for tumor-agnostic cancer detection. However, systematic biases challenge their cross-cohort generalization. We introduce LIONHEART, an open source cancer detection method specifically optimized to generalize across datasets. The method correlates bias-corrected …
dk, sg
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Maibritt Nørgaard, Maria Rusan, Karoline Kondrup, Ea Marie Givskov Sørensen et autres
BACKGROUND: Intrinsic and acquired resistance to second-generation anti-androgens pose a significant clinical challenge in the treatment of metastatic castration-resistant prostate cancer (mCRPC). Novel biomarkers to predict treatment response and inform alternative treatment options are urgently needed. METHODS: Deep targeted sequencing, with a …
dk, se, be
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Ludvig Renbo Olsen, Denis Odinokov, Jakob Qvortrup Holsting, Karoline Kondrup et autres
Abstract The fragmentation patterns of whole genome sequenced cell-free DNA are promising features for tumor-agnostic cancer detection. However, systematic biases challenge their cross-cohort generalization. We introduce LIONHEART, a novel, open source cancer detection method specifically optimized to generalize across datasets. The method …
dk, sg
(code pays fourni par la source)