Accès ouvert
2025
article
OpenAlex
Mayuri Bhatia, Ashutosh S. Phadte, Anna Lakhina, Anthony R Monte Carlo III et autres
DNA triplet repeat expansion causes several primarly neurological disorders like Huntington's disease, myotonic dystrophy type 1, and fragile-X related disorders. There is general consensus that recognition of extrahelical extrusions or hairpin-loop structures (formed by strand slippage) by the DNA mismatch repair protein …
us
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Accès ouvert
2025
article
OpenAlex
Arit Ghosh, Megan Coffin, Sarah Barndt, Vincent Schulz et autres
ABSTRACT: Mammalian red blood cells are generated via a terminal erythroid differentiation pathway culminating in cell polarization and enucleation. Actin filament (F-actin) polymerization is critical for enucleation, but the underlying molecular regulatory mechanisms remain poorly understood. We used publicly available RNA sequencing …
us, tw
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Mayuri Bhatia, Ashutosh S. Phadte, Anna Lakhina, Anthony R. Monte Carlo et autres
DNA triplet repeat expansion is the mutational cause of neurodegenerative disorders such as Huntington's disease, myotonic dystrophy type 1, and fragile-X related disorders. There is a general consensus that recognition of extrahelical extrusions or hairpin-loop structures (formed by strand slippage) by the …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Fenglin Li, Ashutosh S. Phadte, Mayuri Bhatia, Sarah Barndt et autres
FAN1 is a DNA dependent nuclease whose proper function is essential for maintaining human health. For example, a genetic variant in FAN1, Arg507 to His hastens onset of Huntington’s disease, a repeat expansion disorder for which there is no cure. How the …
us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Arit Ghosh, Megan Coffin, Sarah Barndt, Vincent Schulz et autres
Abstract Mammalian red blood cells are generated via a terminal erythroid differentiation pathway culminating in cell polarization and enucleation. Actin filament polymerization is critical for enucleation, but the molecular regulatory mechanisms remain poorly understood. We utilized publicly available RNA-seq and proteomics datasets …
us, tw
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Anna Pluciennik, Fenglin Li, Ashutosh S. Phadte, Mayuri Bhatia et autres
us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Fei Li, Ashutosh S. Phadte, Mayuri Bhatia, Sarah Barndt et autres
FAN1 is a DNA dependent nuclease whose proper function is essential for maintaining human health. For example, a genetic variant in FAN1, Arg507 to His hastens onset of Huntington's disease, a repeat expansion disorder for which there is no cure. How the …
us
(code pays fourni par la source)