Keely Y. Ji

CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer

Alex C.Y. Chen, Keely Y. Ji, Cansu Yerinde, Nelson H. Knudsen et autres

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Abstract 4258: In vivo genome-scale enhancer screen decodes T cell fate decisions in the tumor

Keely Y. Ji, Alex C.Y. Chen, Laura G. Hinojosa, Bolutito Babatunde et autres

Abstract During chronic infection and cancer progression, T cells enter a dysfunctional state called exhaustion, posing a significant challenge to disease control and immunotherapy outcomes. Previously, we and others have shown that T cell exhaustion is a differentiation process regulated at the …

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Abstract 2073: In vivo single-cell CRISPR screens identify targets to restore T cell function in aged tumors.

Alex C.Y. Chen, Keely Y. Ji, Cansu Yerinde, Daniela Martinez et autres

Abstract Aging brings significant changes to the immune system, which slow down the immune response and make it less effective at detecting and fighting cancer. However, the mechanisms behind this are not fully understood. To address this open question, we focus on …

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CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer

A. Chen, Keely Y. Ji, Cansu Yerinde, Nelson H. Knudsen et autres

Abstract Immune aging is being increasingly recognized as a critical barrier to effective cancer immunotherapy, as the aged tumor microenvironment (TME) drives T cell dysfunction and impairs immune control of cancer 1–4 . However, the key molecular drivers of this process as …

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Abstract LB066: Cytokine and chemokine screening reveals altered NK-DC-T cell crosstalk in the aged tumor microenvironment

Alex C. Chen, Marijana Ručević, Sneha Jaiswal, Daniela Martínez et autres

Abstract The etiology and effects of age-related immune dysfunction in cancer remain incompletely understood. We previously demonstrated that the limited priming and function of CD8+ T cells in aged tumor-bearing mice are linked to altered NK-DC-T cell crosstalk within the aged tumor …

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The aged tumor microenvironment limits T cell control of cancer

Chang-Yu Chen, Sneha Jaiswal, Daniela Martínez, Cansu Yerinde et autres

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Abstract 3234: A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2-deficient pancreatic cancer

Suyakarn Archasappawat, Eunjung Lee, Keely Y. Ji, Jocelyn V. Pena et autres

Abstract Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in the United States, with the lowest five-year survival rate of all cancers. Around 10% of pancreatic cancer diagnoses are thought to be familial pancreatic cancer (FPC). BRCA2 pathogenic …

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Abstract 3921: The aged tumor microenvironment limits CD8+ T cell control of cancer

Alex C.Y. Chen, Sneha Jaiswal, Daniela Martínez, Cansu Yerinde et autres

Abstract Aging is associated with progressive loss of immune function, which parallels the rise in cancer incidence. The etiology and impact of age-related CD8+ T cell dysfunction in cancer remain poorly understood. Here, we demonstrate that increased tumor growth in aged hosts …

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Abstract A079: A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2-deficient pancreatic cancer

Suyakarn Archasappawat, Eunjung Lee, Keely Y. Ji, Jocelyn V. Pena et autres

Abstract Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in the United States, with the lowest five-year survival rate of all cancers. Around 10% of pancreatic cancer diagnoses are thought to be familial pancreatic cancer (FPC). BRCA2 pathogenic …

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Engrailed‐1 Promotes Pancreatic Cancer Metastasis

Jihao Xu, Jae‐Seok Roe, Eunjung Lee, Claudia Tonelli et autres

Engrailed-1 (EN1) is a critical homeodomain transcription factor (TF) required for neuronal survival, and EN1 expression has been shown to promote aggressive forms of triple negative breast cancer. Here, it is reported that EN1 is aberrantly expressed in a subset of pancreatic …

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A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer

Eunjung Lee, Suyakarn Archasappawat, Keely Y. Ji, Jocelyn V. Pena et autres

Pancreatic cancer is one of the deadliest diseases in human malignancies. Among total pancreatic cancer patients, ~10% of patients are categorized as familial pancreatic cancer (FPC) patients, carrying germline mutations of the genes involved in DNA repair pathways (e.g., BRCA2). Personalized medicine …

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A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer

Eunjung Lee, Suyakarn Archasappawat, Keely Y. Ji, Jocelyn V. Pena et autres

Abstract Pancreatic cancer is one of the deadliest diseases in human malignancies. Among total pancreatic cancer patients, ∼10% of patients are categorized as familial pancreatic cancer (FPC) patients, carrying germline mutations of the genes involved in DNA repair pathways ( e.g., BRCA2 …

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