Accès ouvert
2026
preprint
OpenAlex
Dong-Hyeon Kim, Jongwan Kim, Sangwoo Kang, Hwa-Ryeon Kim et autres
Summary How transcription factors contribute to DNA damage repair (DDR) independent of canonical gene regulation remains poorly understood. Here, we show that DNA double-strand break (DSB) triggers a functional state transition in TEAD, disengaging it from YAP-dependent transcription and translocating it to …
kr
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Accès ouvert
2026
article
OpenAlex
Han‐Teo Lee, Jae‐Seok Roe, Hong‐Duk Youn
Cell metabolism has long been recognized as a fundamental process for energy production, biomolecule synthesis, and cell survival. During transitions between stem and somatic states, central carbon metabolism is rewired with concurrent changes in chromatin regulation and gene expression. Because a specific …
kr, Éthiopie, pr
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Accès ouvert
2026
article
OpenAlex
Na Hyun Park, Hwa-Ryeon Kim, Hye Young Kim, Soo Young Lee et autres
H3K79 methylation by Dot1 (disruptor of telomeric silencing-1) plays critical roles in multiple cellular processes potentially by modulating chromatin structure and gene expression. However, the genome-wide distribution patterns of H3K79me1, H3K79me2, and H3K79me3 and the mechanisms specifying these patterns remain unclear. Here, …
kr, Éthiopie
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Accès ouvert
2025
article
OpenAlex
Minji Park, Hwa-Ryeon Kim, Ji Hoon Park, Y. T. Kim et autres
Transcription factors are key regulators of gene expression and play essential roles in various diseases, yet their lack of small-molecule binding pockets makes them difficult to target with drugs. Internal RNA modifications, such as N6-methyladenosine, are widespread in mammalian cells, but how …
kr
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Accès ouvert
2025
article
OpenAlex
June-Ha Shin, Hwa-Ryeon Kim, Jae‐Seok Roe
Loss-of-function mutations in the TP53 gene are the most frequent genetic events in human malignancies. However, the extent to which missense TP53 mutations confer oncogenic gain-of-function (GOF) properties remains incompletely understood. Using genetically defined pancreatic cancer organoid models, we demonstrated that mutant …
kr
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Accès ouvert
2025
preprint
OpenAlex
Reuben Franklin, Brian Zhang, Meijuan Chen, Brian T. Do et autres
The manipulation of DNA replication and transcription can be harnessed to control cell fate. Central to the regulation of these DNA-templated processes are histone chaperones, which in turn are emerging as cell fate regulators. Histone chaperones are a group of proteins with …
us, kr
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Accès ouvert
2025
article
OpenAlex
June-Ha Shin, Hye-Been Yoo, Jae‐Seok Roe
Epigenetic regulators, known as "writers," erasers," and "readers," are essential for controlling gene expression by adding, removing, or recognizing post-translational modifications to histone tails, respectively. These regulators significantly affect genes involved in cancer initiation and maintenance. Recently, several clinical strategies targeting these …
kr
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Accès ouvert
2025
article
OpenAlex
So Yeon Park, Sungeun Ju, Jae Hoon Lee, Hwa-Ryeon Kim et autres
Until now, Hippo pathway-mediated nucleocytoplasmic translocation has been considered the primary mechanism by which yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) transcriptional coactivators regulate cell proliferation and differentiation via transcriptional enhanced associate domain (TEAD)-mediated target gene expression. In this …
kr, cn
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Accès ouvert
2024
erratum
OpenAlex
Young Nam, June-Ha Shin, Seongmi Kim, Chi Hyun Hwang et autres
In this article, the affiliation of Jaewhan Song “Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea” has been updated to “Department of Biochemistry, College of Life Science and Technology, Institute for Bio-medical Convergence Science and Technology, Yonsei …
kr
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Accès ouvert
2024
article
OpenAlex
Soohyun Lee, Hwa‐Ryeon Kim, Yaejin Woo, Jiyoung Kim et autres
The androgen receptor (AR) is an attractive target for treating prostate cancer, considering its role in the development and progression of localized and metastatic prostate cancer. The high global mortality burden of prostate cancer, despite medical treatments such as androgen deprivation or …
kr
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Accès ouvert
2024
article
OpenAlex
Myeong‐Gyun Kang, Hwa-Ryeon Kim, Hee Yong Lee, Chulhwan S. Kwak et autres
High Resolution Image Download MS PowerPoint Slide Mitochondrial thermogenesis is a process in which heat is generated by mitochondrial respiration. In living organisms, the thermogenic mechanisms that maintain body temperature have been studied extensively in fat cells with little knowledge on how …
kr
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Accès ouvert
2024
article
OpenAlex
Young Nam, June-Ha Shin, Seongmi Kim, Chi Hyun Hwang et autres
Tumour necrosis factor receptor 1 (TNFR1) induces the nuclear factor kappa-B (NF-κB) signalling pathway and regulated cell death processes when TNF-α ligates with it. Although mechanisms regulating the downstream pathways of TNFR1 have been elucidated, the direct regulation of TNFR1 itself is …
kr
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