Accès ouvert
2025
article
OpenAlex
Huaxiu Zeng, Pooja Singh, Rajesh Sinha, C.T. Stephens et autres
Introduction: Arsenicals like lewisite are highly toxic vesicant chemical warfare agents that cause severe skin damage and systemic inflammation. Exposure activates cytokine release, leading to pulmonary injury, including edema, hemorrhage, and in severe cases, Bronchiolitis Obliterans Syndrome (BOS), marked by airway fibrosis …
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Accès ouvert
2025
article
OpenAlex
Rajesh Sinha, Pooja Singh, Huaxiu Zeng, Abhishek Kumar et autres
Chronic Obstructive pulmonary disease (COPD) is a global health concern affecting over 300 million individuals worldwide, with airway fibrosis and subsequent small airway narrowing identified as the primary mechanism driving disease progression. This pathological process is characterized by accelerating lung aging, manifesting …
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Accès ouvert
2023
article
OpenAlex
K.G. Dsouza, Ranu Surolia, Tejaswini Kulkarni, Fu Jun Li et autres
BACKGROUND: Interstitial lung diseases (ILD) encompass a heterogenous group of diffuse parenchymal lung disorders characterized by variable degrees of inflammation and fibrosis. Pretherapeutic clinical testing models for such diseases can serve as a platform to test and develop effective therapeutic strategies. In …
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Accès ouvert
2023
article
OpenAlex
Ranu Surolia, Fu Jun Li, K.G. Dsouza, Huaxiu Zeng et autres
Organoarsenicals, such as lewisite and related chloroarsine, diphenylchloroarsine (DPCA), are chemical warfare agents developed during World War I. Stockpiles in Eastern Europe remain a threat to humans. The well-documented effects of cutaneous exposure to these organoarsenicals include skin blisters, painful burns, and …
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