Zhao Le

Improving 10-year cardiovascular disease risk prediction using automated machine learning

Simin He, Juping Wang, Zhao Le, Yaqi Xu et autres

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Mechanistic Insights and Therapeutic Potential of Plant-Derived Exosome-Like Nanovesicles in Skin Tissue Regeneration

Xiaomeng Ma, Jiayu Shi, Ruifang Li, Wenjie Hu et autres

The integrity of the skin barrier is paramount for human physiological homeostasis. Recently, plant-derived exosome-like nanovesicles (PENs) lipid bilayer nanostructures inherently enriched with diverse natural bioactive cargos have emerged as transformative nanotherapeutic platforms. Compared to conventional mammalian and microbial-derived extracellular vesicles (EVs), …

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Preparation of a chronic complete atrioventricular block rat model using myocardial surface radiofrequency ablation

Ying Wang, Xu Shaojun, Juan Wang, Zhao Le et autres

Research using rat models of chronic complete atrioventricular block (CAVB) remains limited, and several problems, particularly model instability, persist. This study aimed to optimize the method used to establish a CAVB rat model. The most suitable approach for establishing a CAVB rat …

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Effects of Baduanjin exercise on sleep quality, depressive symptoms, quality of life, and body composition in older adults: a systematic review and meta-analysis of randomized controlled trials

Zhao Le, Mei-Chan Chong, Wan Ling Lee, Weixia Song et autres

Background Baduanjin, a traditional mind–body exercise, may provide benefits for both physical and psychological health among older adults. The present study systematically evaluated its effects on sleep quality, depressive symptoms, quality of life, body composition, and handgrip strength. Methods A systematic search …

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High-rate QAM-aided differential spatial frequency modulation

Yajun Fan, Wencai Yan, Zhao Le, Haihua Ma et autres

Differential spatial frequency modulation (DSFM) represents a novel multiple-input-multiple-output transmission technique. It utilizes subcarriers and transmitting antenna index matrices to convey part of the information in non-coherent communication scenarios. However, when high-order modulation is necessary for spectral-efficiency purposes, the traditional application of …

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Global, regional, and national burden of subarachnoid hemorrhage for adults aged 55 and older from 1990 to 2021, with projections of prevalence to 2050: an analysis for the Global Burden of Disease Study 2021

Yan Lou, Zhao Le, Nan Xu, Lijun Zhang et autres

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Trajectories of depressive symptoms and incident diabetes risk among middle-aged and older adults: A longitudinal cohort study

Zhao Le, Yan Lou, Yun Zou

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基于单细胞核转录组学揭示山羊羔羊棕色脂肪组织从产热表型向成脂型表型的发育转变

Zhao Le, Qingjun Zhu, Minhao Li, Haili Yang

Brown adipose tissue (BAT) is essential for neonatal thermogenesis and early-life metabolic adaptation. In goat neonates, BAT is primarily concentrated in the perirenal region and rapidly regresses during the first month after birth, yet the cellular and molecular programs driving this transition …

Clopidogrel monotherapy is associated with higher mortality risk compared to aspirin: a retrospective analysis of NHANES 1999–2018

Yong He, Yuzhang Bei, Hui Mai, Zhao Le

Background Clopidogrel and aspirin are widely used antiplatelet agents. Although clopidogrel resistance is more prevalent in Asian populations, a Korean study suggested that clopidogrel was superior to aspirin in patients who completed standard dual antiplatelet therapy following percutaneous coronary intervention. However, the …

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GrimAge and GrimAge2 Age Acceleration effectively predict mortality risk: a retrospective cohort study

Yong He, Yixi Wang, Zhao Le

Epigenetic clocks have been widely applied to assess biological ageing, with Age Acceleration (AA) serving as a key metric linked to adverse health outcomes, including mortality. However, the comparative predictive value of AAs derived from different epigenetic clocks for mortality risk has …

Égypte, cn (code pays fourni par la source)

Global, regional and national burden of depressive disorders in adolescents and young adults, 1990–2021: systematic analysis of the global burden of disease study 2021

Zhao Le, Yan Lou, Yuexian Tao, Hangsai Wang et autres

Background: To promote evidence-based policymaking, this research attempts to investigate global trends in depressive disorders among individuals aged 15-39 from 1990 to 2021, determine risk factors, and forecast the next trends from 2022 to 2050. Methods: Data from the Global Burden of …

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[Causes and prevention strategies of postoperative nausea and vomiting after orthognathic surgery].

Kai Luo, Le Liu, Zhao Le, Yanglu Tang et autres

Postoperative nausea and vomiting (PONV) are common complications that mainly occur within 24 h after orthognathic surgery. The incidence of nausea and vomiting after orthognathic surgery remains high and is a difficult problem for patients and surgeons. These complications not only affect …

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