Clopidogrel monotherapy is associated with higher mortality risk compared to aspirin: a retrospective analysis of NHANES 1999–2018
Rattachement africain : Égypte, cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background Clopidogrel and aspirin are widely used antiplatelet agents. Although clopidogrel resistance is more prevalent in Asian populations, a Korean study suggested that clopidogrel was superior to aspirin in patients who completed standard dual antiplatelet therapy following percutaneous coronary intervention. However, the comparative effectiveness of clopidogrel versus aspirin in populations with lower levels of clopidogrel resistance remains to be further investigated.Methods This study included 1,007 participants from NHANES 1999–2018 who were receiving aspirin or clopidogrel monotherapy. Cox proportional hazards regression and Kaplan-Meier survival analyses were used to compare the risks of mortality between the two groups. Sensitivity analyses were conducted by excluding individuals who died within the first 6 months of follow-up.Results Across all Cox models, clopidogrel use was associated with significantly higher risks of all-cause mortality (Model 1, HR1.47, 95%CI 1.20–1.79, p < .01; Model 2, HR1.25, 95%CI 1.02–1.54, p = .03; Model 3, HR 1.33, 95%CI 1.08–1.64, p = .01; Model 4, HR1.31, 95%CI 1.06–1.63, p = .01), stroke and cardiac mortality (Model 1, HR1.76, 95%CI 1.27–2.43, p < .01; Model 2, HR1.41, 95%CI 1.01–1.97, p = .04; Model 3, HR 1.54, 95%CI 1.10–2.17, p = .01; Model 4, HR1.47, 95%CI 1.03–2.08, p = .03) compared with aspirin. These associations remained consistent in sensitivity analyses. Kaplan-Meier survival curves also indicated higher risks of all-cause mortality, stroke and cardiac mortality in the clopidogrel group relative to the aspirin group.Conclusion In this community-based population, clopidogrel monotherapy was associated with higher risks of all-cause mortality, stroke and cardiac mortality compared with aspirin.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Clopidogrel monotherapy is associated with higher mortality risk compared to aspirin: a retrospective analysis of NHANES 1999–2018
- Date Crossref
- 22/07/2025
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Ministry of Agriculture and Land Reclamation Égypte (code pays fourni par la source)Organisme public
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Guangdong Medical College pays non établi dans la noticeUniversité ou école supérieure
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Central People's Hospital of Zhanjiang pays non établi dans la noticeÉtablissement de santé
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Liuyang City Maternal and Child Health Hospital pays non établi dans la noticeÉtablissement de santé
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Agricultural Reclamation Central Hospital of Guangdong Department of Medical Affairs pays non établi dans la noticeÉtablissement de santé
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Guangdong Medical University Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
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Liuyang Jili Hospital Department of Neurology pays non établi dans la noticeÉtablissement de santé
Ministry of Agriculture and Land Reclamation (Égypte), Guangdong Medical College et Central People's Hospital of Zhanjiang, avec 4 autres affiliations. Pays d’affiliation : Égypte.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.