Stéphane Bertin

Population Pharmacokinetics of Levosimendan and its Metabolites OR-1855 and OR-1896 in Critically Ill Adults, Neonates and Infants on Veno-Arterial ECMO

Stéphane Bertin, Monia Guidi, David Haefliger, Paul Thoueille et autres

BACKGROUND AND OBJECTIVE: Levosimendan is an inotrope and vasodilator agent commonly used in critical care, particularly to facilitate weaning from veno-arterial extracorporeal membrane oxygenation (VA-ECMO). However, critical illness and ECMO may affect levosimendan and its clinically relevant metabolites' pharmacokinetics, potentially compromising circulating …

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Population Pharmacokinetics of Propofol in Critically Ill Patients with and Without Extracorporeal Membrane Oxygenation

Stéphane Bertin, David Haefliger, Thomas Mercier, Laurent A. Décosterd et autres

BACKGROUND AND OBJECTIVE: Propofol is commonly used in critically ill patients on extracorporeal membrane oxygenation (ECMO). Although ECMO may theoretically affect drug pharmacokinetics (PK) through various mechanisms, data on propofol PK in this context remain scarce, with only one small recent study …

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Two OB-fold proteins from a Gram-positive conjugative element engage in relaxosome assembly and DNA processing

Haifa Laroussi, Robine Maffo-Woulefack, Julien Cappèle, Hicham Sekkouri Alaoui et autres

Integrative and conjugative elements (ICEs) are widespread genomic islands that propagate by bacterial conjugation. ICEs often spread antibiotic resistance genes and other adaptive genes conferring evolutionary advantages to their hosts. At the initiation of conjugation, the ICE DNA is processed by the …

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Effects of Extracorporeal Membrane Oxygenation Circuits on Drug Sequestration: A Review of Ex Vivo Experiments

Stéphane Bertin, David Haefliger, Antoine Schneider, Raphaël Giraud et autres

Background: Extracorporeal membrane oxygenation (ECMO) can affect the disposition of drugs, notably by sequestering them in a circuit. This review aimed to provide a comprehensive summary of existing ex vivo studies investigating the impact of contemporary ECMO circuits on drug sequestration, and …

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Acétazolamide et effusion uvéale : à propos de deux cas

Stéphane Bertin, Jérémie Villaret, Michel Pâques

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Adaptive Optics Flood Illumination Ophthalmoscopy in Nonhuman Primates

Alexandre Dentel, Elena Brazhnikova, Nathaniel Norberg, Céline Jaillard et autres

Objective: To describe adaptive optics flood illumination ophthalmoscopy (AO-FIO) of the photoreceptor layer in normal nonhuman primates (NHPs) and in the case of a short-term induced retinal detachment (RD). Design: Longitudinal fundamental research study. Subjects: Four NHPs were used to image normal …

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Inducible non-human primate models of retinal degeneration for testing end stage therapies and understanding disease mechanisms

Divya Ail, Diane Nava, In Pyo Hwang, Elena Brazhnikova et autres

Abstract The anatomical differences between the retinas of humans and most animal models pose a challenge for testing novel therapies. Non-human primate (NHP) retina is anatomically closest to the human retina with the presence of a high acuity region called the fovea. …

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Hidden in the Eyes—Recurrence of Systemic Hemopathies Reportedly “In Remission”: Six Cases and Review of Literature

Margot Denier, Sarah Tick, Romain Dubois, Rémy Duléry et autres

Background and Objectives: Secondary ocular localizations of hematological malignancies are blinding conditions with a poor prognosis, and often result in a delay in the diagnosis. Materials and Methods: We describe a series of rare cases of ocular involvement in six patients with …

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Systemic and local immune responses to intraocular AAV vector administration in non-human primates

Divya Ail, Duohao Ren, Elena Brazhnikova, Céline Nouvel-Jaillard et autres

Positive clinical outcomes in adeno-associated virus (AAV)-mediated retinal gene therapy have often been attributed to the low immunogenicity of AAVs and immune privilege of the eye. However, several recent studies have shown potential for inflammatory responses. The current understanding of the factors …

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Systemic and local immune response to intraocular AAV vector administration in non-human primates

Divya Ail, Duohao Ren, Elena Brazhnikova, Céline Nouvel-Jaillard et autres

ABSTRACT The positive clinical outcomes in adeno-associated virus (AAV)-mediated retinal gene therapy have often been attributed to the low immunogenicity of AAVs along with the immune-privilege of the eye. However, several recent preclinical studies and clinical trials have shown potential for inflammatory …

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CYP450 Genotype—Phenotype Concordance Using the Geneva Micrococktail in a Clinical Setting

Kuntheavy Ing Lorenzini, Jules Desmeules, Victoria Rollason, Stéphane Bertin et autres

Pharmacokinetic variability is a major source of differences in drug response and can be due to genetic variants and/or drug-drug interactions. Cytochromes P450 are among the most studied enzymes from a pharmacokinetic point of view. Their activity can be measured by phenotyping, …

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Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates

Grégory Gauvain, Himanshu Akolkar, Antoine Chaffiol, Fabrice Arcizet et autres

Abstract Vision restoration is an ideal medical application for optogenetics, because the eye provides direct optical access to the retina for stimulation. Optogenetic therapy could be used for diseases involving photoreceptor degeneration, such as retinitis pigmentosa or age-related macular degeneration. We describe …

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