Zhenxing Zhai

Efficacy and safety of triple or dual therapies for metastatic hormone-sensitive prostate cancer: a systematic review and Bayesian network meta-analysis

Jingqi Jiang, Yi Wang, Jiangtao Bai, Gaoyang Yang et autres

Aim: To compare triple and dual therapies for efficacy and safety in metastatic hormone-sensitive prostate cancer (mHSPC). Methods: A Bayesian network meta-analysis was conducted to indirectly compare overall survival, progression-free survival and adverse events in mHSPC patients with triple and dual therapies. …

The endoscopic surgical monitoring system-guided impact factors exploring of blood loss and fluid absorption during plasmakinetic TURP: a prospective study in high-risk BPH patients

Jin Qi, J. Y. Zhang, Guilin Wang, Yunxin Zhang et autres

OBJECTIVE: To determine impact factors affecting intraoperative blood loss and fluid absorption by utilizing a novel endoscopic surgical monitoring system (ESMS) for objective quantification in high-risk benign prostatic hyperplasia (BPH) patients undergoing transurethral plasmakinetic resection of the prostate (PK-TURP). METHODS: This prospective …

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Efficacy and safety of triple or dual therapies for metastatic hormone-sensitive prostate cancer: a systematic review and Bayesian network meta-analysis

Jingqi Jiang, Yuhan Wang, Jiangtao Bai, Gaoyang Yang et autres

Aim: To compare triple and dual therapies for efficacy and safety in metastatic hormone-sensitive prostate cancer (mHSPC). Methods: A Bayesian network meta-analysis was conducted to indirectly compare overall survival, progression-free survival and adverse events in mHSPC patients with triple and dual therapies. …

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Comparative effectiveness of multiple androgen receptor signaling inhibitor medicines with androgen deprivation therapy for metastatic hormone-sensitive prostate cancer: a study in the real world

Yutong Lu, Jingqi Jiang, Gaoyang Yang, Hui Ding et autres

Background: The current treatment strategy for metastatic Hormone-Sensitive Prostate Cancer (mHSPC) is the combination of Androgen Receptor Signaling Inhibitors (ARSIs) medicines with androgen deprivation therapy (ADT). However, there is a lack of real-world data comparing the efficacy of different ARSI pharmaceuticals. Therefore, …

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Transperitoneal vs retroperitoneal laparoscopic radical nephrectomy: a double-arm, parallel-group randomized clinical trial

Junyao Liu, Bin Zhang, Peng Qi, Xiaowei Ren et autres

OBJECTIVE: To compare the outcomes of patients undergoing Retroperitoneal laparoscopic Radical nephrectomy (RLRN) and Transperitoneal laparoscopic Radical nephrectomy (TLRN). METHODS: A total of 120 patients with localized renal cell carcinoma were randomized into either RLRN or TLRN group. Mainly by comparing the …

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Atorvastatin Enhances Inhibitory Effects of Irradiation on Tumor Growth by Reducing MSH2 Expression Both in Prostate Cancer Cells and Xenograft Tumor Models

Zhenhua He, Dingkai Xu, Fuhui Shen, Fangang Zeng et autres

BACKGROUND: Prostate cancer (PCa) is the fourth most common tumor in males. OBJECTIVE: This study aimed to investigate effects of atorvastatin (AS) on PCa cells proliferation and clarify the associated mechanisms. METHODS: PCa cell lines were cultured and treated with irradiation (IR) …

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miR-541-3p enhances the radiosensitivity of prostate cancer cells by inhibiting HSP27 expression and downregulating β-catenin

Zhenhua He, Fuhui Shen, Ping Qi, Zhenxing Zhai et autres

Heat shock protein 27 (HSP27), a regulator of cell survival, can enhance the resistance of cancer cells to radiotherapy. As microRNA-541-3p (miR-541-3p) was recently predicted to be a putative upstream modulator of HSP27, the present study was designed to investigate the function …

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Atorvastatin Enhances Effects of Radiotherapy on Prostate Cancer Cells and Xenograft Tumor Mice Through Triggering Interaction Between Bcl-2 and MSH2

Zhenhua He, Jingmin Yuan, Fuhui Shen, Fangang Zeng et autres

BACKGROUND Prostate cancer (PCa) is considered to be the 4th most common cancer in males in the world. This study aimed to explore effects of atorvastatin on colony formation of PCa cells and radio-resistance of xenograft tumor models. MATERIAL AND METHODS PCa …

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Synergistic effect of bladder cancer-specific oncolytic adenovirus in combination with chemotherapy

Shuwen Li, Fang Wang, Zhenxing Zhai, Shengjun Fu et autres

Gene therapy with adenoviral early region gene (E1A) may enhance the susceptibility of neoplastic cells to chemotherapy-induced cell death. Our previous study developed a urothelium-specific oncolytic serotype 5 adenovirus (Ad5) with the uroplakin II (UPII) promoter controlling E1A expression. The present study …

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Effect of combined treatment of radiation and tissue-specific recombinant oncolytic adenovirus on bladder cancer cells

Hongjuan Zhang, Fang Wang, Chunjie Mao, Zuncheng Zhang et autres

PURPOSE: Gene therapy combined with radiation has shown promising potential for the treatment of tumors. This paper aimed to clarify the synergistic effect of radiotherapy combined with the bladder cancer tissue-specific oncolytic adenovirus (Ad-PSCAE-UPII-E1A) on bladder cancer cells and to study the …

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Modified ureterosigmoidostomy (Mainz Pouch II) urinary diversion: 10 years experience and follow-up

Panfeng Shang, Zhongjin Yue, Yanzong Zhao, Faying Yang et autres

Objective To report 10 years experience in modified ureterosigmoidostomy (Mainz Pouch Ⅱ) urinary diversion and evaluate its long-term outcome. Methods From October 2004 to December 2014, 248 patients , including 205 men and 43 women, had underwent Mainz Pouch Ⅱ urinary diversion …

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[Updated roles of SIRT1 in prostate diseases].

Zhiming Ma, Yuejun Tian, Zhiping Wang, Zhenxing Zhai

Silent information regulator 1(SIRT1),an NAD+dependent class-III histone deacetylase,is implicated in diverse cellular processes. SIRT1 has been reported as a key regulator of metabolism,oxidative stress,and cell survival,proliferation,apoptosis and autophagy. It also plays an important role in a variety of physiological processes and health …