Toshikuni Kawamura

Role of Chitinase 3–like‐1 in Myelofibrosis via Fibroblast‐Produced Extracellular Matrix Enhancement

Shoichiro Kato, Toshikuni Kawamura, T. Maekawa, Hiraku Ogata et autres

ABSTRACT Cluster of differentiation 14 + monocytes produced spindle‐shaped fibrocytes, similar to fibroblasts. Recent studies have reported that fibrocytes are crucial for the development and progression of primary myelofibrosis (MF); however, their functional role remains unclear. We compared monocytes and fibrocytes using …

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Sequential Analysis of Murine Myelofibrosis Models Using a Novel Deep Learning‐Based Fibrosis Quantitative Method

Toshikuni Kawamura, Takaaki Maekawa, Keita Kouzu, Hiraku Ogata et autres

ABSTRACT Introduction Primary myelofibrosis (MF) is characterized by MF, splenomegaly, and extramedullary hematopoiesis. MF initially presents with reticular fibers (RFs) and progresses to increased collagen fiber deposition in the advanced stages. Although recent clinical trials have adopted MF improvement as an evaluation …

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P1007: SPLENOMEGALY DEVELOPMENT PRECEDES THE PROGRESS OF HEMATOPOIETIC STEM CELLS MIGRATION TO SPLEEN IN MURINE MYELOFIBROSIS MODELS

Toshikuni Kawamura, Takaaki Maekawa, Hiraku Ogata, Noriaki Tachi et autres

Topic: 15. Myeloproliferative neoplasms - Biology & Translational Research Background: Primary myelofibrosis has characteristics such as myelofibrosis (MF), splenomegaly, and extramedullary hematopoiesis. It is typically believed that in primary MF, hematopoietic stem cells (HSCs) migrate out of the bone marrow niche and …

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MO10-4 Novel non-invasive biomarkers for the detection of myelofibrosis in patients with myeloproliferative neoplasms

Takaaki Maekawa, Tomoyuki Yoshikawa, Miki Moriiwa, Aoi Hirata et autres

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Prognostic impact of chromosomal changes at relapse after allogeneic hematopoietic cell transplantation for acute myeloid leukemia or myelodysplastic syndrome

Yosuke Okada, Hideki Nakasone, Yuhei Nakamura, Masakatsu Kawamura et autres

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The Prognostic Impact of MYC Gene-Related Abnormalities on Multiple Myeloma Outcome through Fluorescence in situ Hybridization Analysis

Yosuke Okada, Masahiro Teramoto, Noriaki Tachi, Toshikuni Kawamura et autres

INTRODUCTION: Chromosomal abnormalities (CAs) have been identified as important factors in determining the biological features and prognostic value of multiple myeloma (MM). MYC gene-related abnormalities (MYC GAs) are one of the CAs, but their unfavorable impact has not been fully investigated in …

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[Successful treatment of secondary graft failure after allogeneic stem cell transplantation for aplastic anemia with eltrombopag].

Kosuke Takano, Takuya Izumi, Toshikuni Kawamura, Toshikatsu Horiuchi et autres

Herein we report a case of successful treatment of secondary graft failure due to poor graft function (PGF) using eltrombopag. A 25-year-old woman with aplastic anemia (stage 3) underwent allogeneic bone marrow transplantation (BMT) from her HLA-matched brother. Neutrophil engraftment was achieved …

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[Isolated central nervous system relapse of Philadelphia chromosome-positive acute lymphoblastic leukemia during ponatinib maintenance therapy].

Emi Kemmoku, Toshikuni Kawamura, Hiraku Ogata, Keita Saito et autres

A 65-year-old man was diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukemia with no initial central nervous system (CNS) involvement. Complete remission was achieved after the induction therapy. However, during consolidation therapy, he developed septic shock and pneumocystis pneumonia, leading to interruption in …

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[Bendamustine and rituximab combination therapy for recurrent indolent B-cell lymphomas: a retrospective single-institution study].

Masahiro Teramoto, Takehiro Sone, Kohei Takada, Hiraku Ogata et autres

This retrospective study evaluated the outcomes of patients treated with combination of bendamustine and rituximab (BR) for recurrent indolent B-cell lymphoma from January 2011 to February 2018 in our department. The cohort included 36 males and 27 females, and majority of the …

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Chitinase 3-like 1 Produced By Fibrocytes Promotes Myelofibrosis

Shoichiro Kato, Takaaki Maekawa, Hiraku Ogata, Yukiko Osawa et autres

Introduction Monocyte-derived fibrocytes are spindle-shaped fibroblast-like blood cells derived from a sub-population of CD14+ monocytes. Recent studies have shown that fibrocytes play a key role in the pathogenesis of primary myelofibrosis (MF), and these cells have attracted attention as novel therapeutic targets …

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Chitinase 3-like 1 produced by fibrocytes promotes myelofibrosis and is a potent therapeutic target

Kato Shoichiro, Takaaki Maekawa, Hiraku Ogata, Yukiko Osawa et autres

Increased SLAMF7high monocytes in myelofibrosis patients harboring JAK2V617F provide a therapeutic target of elotuzumab

Takaaki Maekawa, Shoichiro Kato, Toshikuni Kawamura, Kohei Takada et autres

Monocyte-derived fibrocytes recently garnered attention because the novel pathogenesis of myelofibrosis (MF), and suppression of fibrocyte differentiation by serum amyloid P remarkably improved MF. We previously revealed that human fibrocytes highly expressed signaling lymphocytic activation molecule F7 (SLAMF7) compared with macrophages and …

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