Cuiming Sun

Letter to the editor: “real-life effectiveness of antiviral therapy for HCV infection with pangenotypic regimens in HIV coinfected patients”

Cuiming Sun, Ying Wen, Shi Tang

To the Editor,We read the paper “Real-life effectiveness of antiviral therapy for HCV infection with pangenotypic regimens in HIV coinfected patients” published by Piekarska A, et al [1] with great...

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Successful treatment of pulmonary hypertension due to HIV infection and amphetamine snorting: a case report

Cuiming Sun, Ying Wen, Yanli Chen

HIV infection is one of the high-risk factors for pulmonary hypertension (PH). HIV-related PH is associated with non-AIDS-related comorbidities. In this study, we report a case of pulmonary hypertension with several concomitant risk factors who experienced a complete clinical improvement after drug …

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SARS-CoV-2 detection via metagenomic next-generation sequencing of bronchoalveolar lavage fluid/sputum in lymphoma patients receiving B-cell-depleting therapy: a case report of two cases

Cuiming Sun, Zhidan Zhang

We describe two cases of coronavirus disease 2019 (COVID-19) infection in patients with lymphoma receiving B-cell-depleting therapy. Metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF)/sputum showed ongoing viral replication, despite repeated nasopharyngeal swabs being negative for severe acute respiratory syndrome coronavirus …

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Current Knowledge About Long-term Liver Outcome Among Hepatitis B Virus/HIV–Coinfected Patients

Cuiming Sun, Ziwei Yang, Ying Wen

Cuiming Sun, Ziwei Yang, Ying Wen; Current knowledge about long-term liver outcome among HBV/HIV coinfected patients, Clinical Infectious Diseases, , ciae2

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Commentary: Case Report: Lenvatinib for the treatment of recurrent hepatocellular carcinoma in people living with HIV: a report of two cases

Cuiming Sun, Ying Wen, Jin Zhou

Lenvatinib for the treatment of recurrent hepatocellular carcinoma in people living with HIV: a report of two cases

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Role of Macrophages in Liver Fibrosis.

Cuiming Sun, Akihiro Matsukawa

Liver fibrosis, which ultimately leads to liver cirrhosis and hepatocellular carcinoma, is a major health burden worldwide. The progression of liver fibrosis is the result of the wound-healing response of liver to repeated injury. Hepatic macrophages are cells with high heterogeneity and …

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Target the concomitant risk factors for pulmonary hypertension in an HIV-positive man: a case report

Cuiming Sun, Ying Wen, Yanli Chen

Abstract Background Pulmonary hypertension (PH) is a progressive disease characterized by elevated pulmonary arterial pressure causing right ventricular failure and death. HIV infection is one of the high-risk factors for the development of PH and HIV-related PH is associated with non-AIDS-related comorbidities. …

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Individualized Therapeutic Choice for Hiv-Positive Pulmonary Hypertension: A Case Report

Cuiming Sun, Ying Wen, Yanli Chen

The 2021 Incentive Award of the Okayama Medical Association in General Medical Science (2021 Yuuki Prize)

Cuiming Sun

A : Spred2 controls the severity of Concanavalin A-induced liver damage by limiting interferon-

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The Screening of Hepatitis B and Hepatitis C Virus Infection among HIV-Infected Inpatients and Evaluation of Correlated Characteristics in a General Hospital in Shenyang, Liaoning, China

Chengbo Li, Ying Zhou, Yu Wang, Sheng Liu et autres

Background: In this study, we surveyed the prevalence of hepatitis B virus (HBV) surface antigen (HBsAg) and hepatitis C virus (HCV) antibody (anti-HCV) among inpatients with human immunodeficiency virus (HIV) infection and analyzed the correlated factors. Methods: We conducted a retrospective data …

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Spred2 controls the severity of Concanavalin A-induced liver damage by limiting interferon-gamma production by CD4+ and CD8+ T cells

Cuiming Sun, Masayoshi Fujisawa, Toshiaki Ohara, Qiuying Liu et autres

Mitogen-activated protein kinases (MAPKs) are involved in T cell-mediated liver damage. However, the inhibitory mechanism(s) that controls T cell-mediated liver damage remains unknown. We investigated whether Spred2 (Sprouty-related, EVH1 domain-containing protein 2) that negatively regulates ERK-MAPK pathway has a biological impact on …

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Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin

Akina Kawara, Ryo Mizuta, Masayoshi Fujisawa, Toshihiro Ito et autres

Abstract The mitogen-activated protein kinase (MAPK) pathways are involved in many cellular processes, including the development of fibrosis. Here, we examined the role of Sprouty-related EVH-1-domain-containing protein (Spred) 2, a negative regulator of the MAPK-ERK pathway, in the development of bleomycin (BLM)-induced …

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