James Pat McAllister

Neuroinflammatory pathways and potential therapeutic targets in neonatal post-hemorrhagic hydrocephalus

Lauren N. Schulz, Marie Michenkova, Michelle Ariana Wedemeyer, Jonathan Pindrik et autres

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Ventricular catheter tissue obstruction and shunt malfunction in 9 hydrocephalus etiologies

María García‐Bonilla, Jacob M. Gluski, Miguel Angel Ruiz-Cardozo, Ayodamola Otun et autres

OBJECTIVE: Hydrocephalus is a neurological disorder with an incidence of 80-125 per 100,000 births in the United States. The most common treatment, ventricular shunting, has a failure rate of up to 85% within 10 years of placement. The authors aimed to analyze …

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Reduction of cell surface attachment in experimental hydrocephalus using a novel ventricular catheter with modified tethered liquid perfluorocarbon

María García‐Bonilla, Carolyn A. Harris, Saibal Bandyopadhyay, Jason H. Moore et autres

OBJECTIVE: Ventriculoperitoneal shunting, the most common treatment for the neurological disorder hydrocephalus, has a failure rate of up to 98% within 10 years of placement, mainly because of proximal obstruction of the ventricular catheter (VC). The authors developed a new VC design …

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Impaired neurogenesis with reactive astrocytosis in the hippocampus in a porcine model of acquired hydrocephalus

María García‐Bonilla, Arjun J. Nair, Jason H. Moore, Leandro Castañeyra-Ruiz et autres

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Outcomes of the 2019 hydrocephalus association workshop, "Driving common pathways: extending insights from posthemorrhagic hydrocephalus"

Jason K. Karimy, Jessie Newville, Cameron Sadegh, Jill A. Morris et autres

The Hydrocephalus Association (HA) workshop, Driving Common Pathways: Extending Insights from Posthemorrhagic Hydrocephalus, was held on November 4 and 5, 2019 at Washington University in St. Louis. The workshop brought together a diverse group of basic, translational, and clinical scientists conducting research …

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The effect of A1 and A2 reactive astrocyte expression on hydrocephalus shunt failure

Fatemeh Khodadadei, Rooshan Arshad, Diego M. Morales, Jacob M. Gluski et autres

BACKGROUND: The composition of tissue obstructing neuroprosthetic devices is largely composed of inflammatory cells with a significant astrocyte component. In a first-of-its-kind study, we profile the astrocyte phenotypes present on hydrocephalus shunts. METHODS: qPCR and RNA in-situ hybridization were used to quantify …

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Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter

María García‐Bonilla, Leandro Castañeyra-Ruiz, Sarah H. Zwick, Michael Talcott et autres

BACKGROUND: Hydrocephalus is a neurological disease with an incidence of 80-125 per 100,000 births in the United States. Neuropathology comprises ventriculomegaly, periventricular white matter (PVWM) alterations, inflammation, and gliosis. We hypothesized that hydrocephalus in a pig model is associated with subventricular and …

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The Effect of A1/A2 Reactive Astrocyte Expression on Hydrocephalus Shunt Failure

Fatemeh Khodadadei, Rooshan Arshad, Diego M. Morales, Jacob M. Gluski et autres

Abstract Understanding the composition characteristics of the glial scar contributing to the high failure rate of neuroprosthetic devices implanted in the brain has been limited, to date, with the evaluation of cells, tissue, and biomarkers obstructing the implant. However, there remains a …

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Genetics and Molecular Pathogenesis of Human Hydrocephalus

María García‐Bonilla, James Pat McAllister, David D. Limbrick

Hydrocephalus is a neurological disorder with an incidence of 80-125 per 100,000 live births in the United States. The molecular pathogenesis of this multidimensional disorder is complex and has both genetic and environmental influences. This review aims to discuss the genetic and …

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Diffusion basis spectrum imaging in post-hemorrhagic hydrocephalus of prematurity

Albert M. Isaacs, Jeffrey J. Neil, James Pat McAllister, Sonika M Dahiya et autres

ABSTRACT Objective The debilitating neurological deficits of neonatal post-hemorrhagic hydrocephalus (PHH) have been linked to periventricular white matter injury. To improve understanding of the deleterious mechanisms underlying PHH-related brain injury, this study applied diffusion basis spectrum imaging (DBSI) for the first time …

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Glial Associated Impairment of the Glymphatic System in Experimental Neonatal Hydrocephalus

Joseph Tyler Vasas, James Pat McAllister, Ramin Eskandari

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Cerebrospinal Fluid Biomarkers of Neuroinflammation in Children with Hydrocephalus and Shunt Malfunction

Carolyn A. Harris, Diego M. Morales, Rooshan Arshad, James Pat McAllister et autres

Abstract Background: Cerebrospinal fluid (CSF) shunt systems fail approximately 30% of the time within the first year of shunt implantation, while 98% of all patients with hydrocephalus (HCP) will suffer shunt failure in their lifetime. Perhaps due to the heterogeneity in etiology …

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