Michael Talcott

PO-02-331 HIGH-FREQUENCY SINE-WAVE PULSED FIELD ABLATION ENABLES DEEP VENTRICULAR LESIONS WITHOUT PARALYTICS: PRECLINICAL VALIDATION OF A NOVEL PFA WORKFLOW

Melvin F. Lorenzo, Mark A. Zurcher, Nathan Kastelein, Paul Rebillot et autres

In Vivo Evaluation of a Novel Long‐Term Intravascular Implantable Continuous Blood Glucose Monitor in an Ovine Model: A Glucotrack Inc. Investigation

Mark A. Tapsak, Michael Talcott, James P. Thrower, Paul V. Goode et autres

Implantable intravascular continuous blood glucose monitors (CBGMs) offer a promising approach for accurately measuring glucose levels with short lag times and improved reliability when compared with conventional laboratory-based point-of-care or handheld glucometers. In this study, 34 Glucotrack long-term intravascular CBGM devices were …

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The Veterinary Consortium for Research Animal Care and Welfare Survey on Revisions to the Eighth Edition of the Guide for the Care and Use of Laboratory Animals

Kathleen P Storves, Michael Talcott, Jeanne Marie Wallace, B. Taylor Bennett et autres

The Veterinary Consortium for Research Animal Care and Welfare (VCRACW or Consortium) was established in 2019 to provide accurate information to the public, lawmakers, and the scientific community about the veterinary care and welfare of research animals. The consortium includes 2 representatives …

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An autonomous implantable device for the prevention of death from opioid overdose

Joanna L. Ciatti, Abraham Vázquez‐Guardado, Victoria E. Brings, Jihun Park et autres

Opioid overdose accounts for nearly 75,000 deaths per year in the United States, now a leading cause of mortality among young people aged 18 to 45 years. At overdose levels, opioid-induced respiratory depression becomes fatal without the administration of naloxone within minutes. …

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Transplantation of Pig Metanphroi

Sharon A. Rogers, Michael Talcott, Marc R. Hammerman

To determine whether pig metanephroi grow and differentiate after allotransplantation or xenotransplantation across a highly disparate barrier, we implanted metanephroi from embryonic day 28 (E28) pig embryos into the omentum of unilaterally nephrectomized adult pigs or C57Bl/6J mice (hosts). Some mouse hosts …

An Autonomous Implantable Device for the Prevention of Death from Opioid Overdose

Joanna L. Ciatti, Abraham Vázquez‐Guardado, Victoria E. Brings, Jihun Park et autres

Opioid overdose accounts for nearly 75,000 deaths per year in the United States, representing a leading cause of mortality amongst the prime working age population (25-54 years). At overdose levels, opioid-induced respiratory depression becomes fatal without timely administration of the rescue drug …

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1010-P: In Vivo Evaluation of Novel Long-Term Intravascular Implantable Continuous Blood Glucose Monitor in a Chronic Ovine Model—A Glucotrack Inc. Investigation

Mark A. Tapsak, Paul V. Goode, JP THROWER, Michael Talcott et autres

Introduction & Objective: This study provides the first in vivo assessment of Glucotrack's long-term implantable Continuous Blood Glucose Monitor (CBGM) in an ovine model. The primary objectives were to evaluate device performance, assess and refine implantation techniques, and examine chronic gross biocompatibility …

Reduction of cell surface attachment in experimental hydrocephalus using a novel ventricular catheter with modified tethered liquid perfluorocarbon

María García‐Bonilla, Carolyn A. Harris, Saibal Bandyopadhyay, Jason H. Moore et autres

OBJECTIVE: Ventriculoperitoneal shunting, the most common treatment for the neurological disorder hydrocephalus, has a failure rate of up to 98% within 10 years of placement, mainly because of proximal obstruction of the ventricular catheter (VC). The authors developed a new VC design …

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Impaired neurogenesis with reactive astrocytosis in the hippocampus in a porcine model of acquired hydrocephalus

María García‐Bonilla, Arjun J. Nair, Jason H. Moore, Leandro Castañeyra-Ruiz et autres

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Translational design for limited resource settings as demonstrated by Vent-Lock, a 3D-printed ventilator multiplexer

Helen Xun, Christopher Shallal, Justin Unger, Runhan Tao et autres

BACKGROUND: Mechanical ventilators are essential to patients who become critically ill with acute respiratory distress syndrome (ARDS), and shortages have been reported due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). METHODS: We utilized 3D printing (3DP) technology to rapidly …

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Translational Design for Limited Resource Settings as Demonstrated by Vent-Lock, A 3D-Printed Ventilator Multiplexer

Helen Xun, Christopher Shallal, Justin Unger, Runhan Tao et autres

Abstract Background: Mechanical ventilators are essential to patients who become critically ill with acute respiratory distress syndrome (ARDS), and shortages have been reported due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: We utilized 3D printing (3DP) technology to …

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Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter

María García‐Bonilla, Leandro Castañeyra-Ruiz, Sarah H. Zwick, Michael Talcott et autres

BACKGROUND: Hydrocephalus is a neurological disease with an incidence of 80-125 per 100,000 births in the United States. Neuropathology comprises ventriculomegaly, periventricular white matter (PVWM) alterations, inflammation, and gliosis. We hypothesized that hydrocephalus in a pig model is associated with subventricular and …

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