Lingmin Zeng

Mitochondrial calcium influx-driven bioenergetics selectively enable drug addiction

Jun Gao, Haixin Zhao, Xiao Han, Lingmin Zeng et autres

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Chronic psychological stress induces pulmonary dysfunction through alveolar macrophage-mediated activation of apoptotic signaling pathways

Lingmin Zeng, Zihui Jin, Yue Wang, Xin Ning et autres

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[Association between HER2 overexpression and recurrence rate in patients with non-muscle-invasive bladder cancer following anthracycline-based intravesical instillation therapy].

Kong M. Li, Minling Liu, Shafei Wu, R P Hong et autres

HER2 high-expression seems to be not only associated with worse clinicopathological features of NMIBC but also a poor RFS in NMIBC patients treated with anthracycline instillation after TURBT.

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[Characteristics of KRAS and HER-family gene mutations in ampullary cancer].

Lingmin Zeng, Shafei Wu, Weixun Zhou, Y Y Liu et autres

In ampullary carcinoma, co-alteration of KRAS and HER-family genes is observed, and HER2 gene mutations account for more than half of HER-family gene abnormities, which may be accompanied by gene amplification.

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Mitochondrial calcium influx-driven bioenergetics in the dopaminergic system selectively enable drug reward

Jun Gao, Haixin Zhao, Xiao Han, Lingmin Zeng et autres

Abstract Drugs of abuse hijack the brain’s reward system, driving pathological dopamine surges that underlie compulsive behavior and addiction. However, directly targeting dopamine signaling for treatment risks disrupting natural reward processes. Here, we identify a bioenergetic mechanism that selectively promotes addiction-related dopamine …

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[Characterization of PIK3CA/AKT1/PTEN gene mutations in hormone receptor- positive/HER2-negative breast cancer].

Minling Liu, Shafei Wu, Yuying Liu, Kong M. Li et autres

In addition to the predominance of common loci, PIK3CA and PTEN gene mutations also have rare loci mutations in the breast cancer, warranting further analysis with an expanded sample size.

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[Evaluation of survival quality of the occupationally exposed population of subway microwave based on SF-36 scale].

Fang Zhou, Lingmin Zeng, Jianing Zhou, Ke Li et autres

The education level, physical exercise, sleep status and microwave exposure dose are important factors affecting the survival quality of microwave exposed personnel. Occupational health education and behavioral life intervention should be strengthened to improve their survival quality.

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Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly

Haixin Zhao, Siqi Chen, Nian Cao, Wenjun Wu et autres

Abstract The mitochondrial calcium uniporter (MCU) complex mediates Ca 2+ entry into mitochondria, which plays a crucial role in regulating cellular energy metabolism and apoptosis. Dysregulation of MCU is implicated in various diseases, such as neurodegenerative disorders, cardiac diseases, and cancer. Despite …

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Berberine is a novel mitochondrial calcium uniporter (MCU) inhibitor that disrupts MCU-EMRE assembly

Haixin Zhao, Siqi Chen, Nian Cao, Wenjun Wu et autres

Summary The mitochondrial calcium uniporter (MCU) complex mediates Ca 2+ entry into mitochondrial, which plays a crucial role in regulating cellular energy metabolism and apoptosis. Dysregulation of MCU is implicated in various diseases, such as neurodegenerative disorders, cardiac diseases and cancer. Despite …

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EPCORE FL-2: Phase 3 trial of epcoritamab with rituximab and lenalidomide (R2) vs chemoimmunotherapy or R2 in previously untreated follicular lymphoma.

Kim Linton, Philip A. Thompson, Stefano Luminari, Carla Casulo et autres

TPS7084 Background: Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma. Most patients with advanced-stage FL in need of systemic therapy are treated with an anti-CD20 monoclonal antibody (eg, rituximab [R] or obinutuzumab [G]) with cyclophosphamide, doxorubicin, vincristine, and prednisone [CHOP] …

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EPCORE FL-1: Phase 3 Trial of Subcutaneous Epcoritamab with Rituximab and Lenalidomide (R 2) Vs R 2 Alone in Patients with Relapsed or Refractory Follicular Lymphoma

Lorenzo Falchi, Franck Morschhauser, Kim Linton, Huiqiang Huang et autres

Background: Follicular lymphoma (FL) is the most common form of indolent non-Hodgkin lymphoma (NHL). Several treatment options are approved by the US Food and Drug Administration for second- or later-line FL therapy, including rituximab + lenalidomide (R 2). However, advanced-stage FL remains …

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Urinary markers differentially associate with kidney inflammatory activity and chronicity measures in patients with lupus nephritis

Ahmad Akhgar, Dominic Sinibaldi, Lingmin Zeng, Alton B. Farris et autres

OBJECTIVE: Lupus nephritis (LN) is diagnosed by biopsy, but longitudinal monitoring assessment methods are needed. Here, in this preliminary and hypothesis-generating study, we evaluate the potential for using urine proteomics as a non-invasive method to monitor disease activity and damage. Urinary biomarkers …

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