Siqi Chen

Chemically Modified DNAzyme with Enhanced Activity for Sensitive MicroRNA Imaging in Live Cells

Jiawen Carmen Chen, Juan Wang, Jiahua Wang, Fang Wang et autres

As critical regulators of gene expression, microRNAs (miRNAs) are key biomarkers and therapeutic targets in cancer. However, current methods for intracellular miRNA imaging are often limited by poor sensitivity and operational complexity. In this study, we identified a site-specifically modified DNAzyme variant, …

cn (code pays fourni par la source)

Human knowledge-enhanced large language model agent for prediction of intestinal disease progression in patients with Crohn's disease: A multicenter retrospective study

Zhoulei Li, Fangping He, Ruonan Zhang, Shanshan Zhu et autres

Effective tools for risk stratification of intestinal disease progression (IDP) in Crohn's disease (CD) patients remain limited. Electronic medical records (EMRs) contain detailed information describing disease characteristics. Large language model (LLM) excels at summarizing and analyzing these data. We developed an LLM-agent …

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Harnessing chemical communication in plant–microbiome and intra-microbiome interactions

Hongfu Li, Yan Hu, Siqi Chen, Yusufjon Gafforov et autres

Chemical communication in plant-microbiome and intra-microbiome interactions weaves a complex network, critically shaping ecosystem stability and agricultural productivity. This non-contact interaction is driven by small-molecule signals that orchestrate crosstalk dynamics and beneficial association. Plants leverage these signals to distinguish between pathogens and …

cn, uz, jp, au (code pays fourni par la source)

Genetic Dissection of Rice Plant-Specific Non-ε Group 14-3-3 Proteins in Response to Phosphate Starvation

Hudong Kuang, Yan Meng, Siqi Chen, Tingyue Deng et autres

The 14-3-3 proteins are highly conserved and widely distributed across eukaryotes. Some 14-3-3 proteins have been identified as regulators of phosphorus (Pi) deficiency tolerance in rice, but their diverse functions remain largely unexplored. In this study, we characterized the role of rice …

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Identification of antioxidant peptides in low-salt dry-cured ham skin using molecular docking and molecular dynamics simulation

Tingting Gao, Yingdao Nan, Siqi Chen, Chenguang Li et autres

In this study, gel chromatography and LC-MS/MS were used to isolate and identify novel antioxidant peptides in low-salt dry-cured ham skin. The peptides AAWGKVGGQAGAHGAEALER, DQALKPTKPMRFLGDE, GVNGFGRIGR, and SLTGEFKGKYYPL, which are non-toxic, non-allergic, stable, and water-soluble, were screened using in silico analysis of …

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Targeting heptad repeats and fusion peptide: nanoparticle vaccine elicits mucosal immune response against SARS-CoV-2 variants

Chaofeng Liang, Rong Li, Zeyu Pu, Ran Chen et autres

The emergence of SARS-CoV-2 variants has underscored the urgent need for innovative vaccine strategies that provide robust and enduring protection against diverse strains. Our study introduces the FP-HR5 nanoparticle vaccine, designed to target the highly conserved S2 subunit of the spike protein, …

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Consistent color preference of largefin longbarbel catfish (Mystus macropterus) across life stages: Implications for aquaculture

Miao Xiang, Haoran Liu, Nian Wei, Siqi Chen et autres

cn (code pays fourni par la source)

Behavioral Characteristics of Largefin Longbarbel Catfish Hemibagrus macropterus: Effects of Sex and Body Size on Aggression and Shelter Selection

Xiaoli Li, Yongjiu Zhu, Siqi Chen, Tingbing Zhu et autres

This study investigated the aggressive behavior of Hemibagrus macropterus (Bleeker) by examining the effects of size combinations (large vs. large (LL), large vs. small (LS), small vs. small (SS)), sex combinations (male vs. male (MM), male vs. female (FM), female vs. female …

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Identification of Novel Umami Peptides from Low-Salt Dry-Cured Ham Skin and Revelation of the Umami Mechanism through Molecular Docking with T1R1/T1R3

Tingting Gao, Xuanyi Liu, Siqi Chen, Chenguang Li et autres

Dry-cured ham is highly favored by consumers due to its unique flavor, which is attributed to its various umami peptides. Four novel umami peptides were isolated from the skin of low-salt dry-cured ham. Sensory evaluations and electronic tongue analysis demonstrated that these …

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Evaluating the anti-inflammatory and antioxidant efficacy of complementary and alternative medicines (CAM) used for management of inflammatory bowel disease: a comprehensive review

Siqi Chen, Kangzhe Xie, Suehad Abou Duhun, Tamara Ortíz

Inflammatory bowel disease (IBD) is a chronic autoimmune condition whose pathogenesis has not been fully elucidated, and current treatments are not definitive and often carry several side effects. The Complementary and Alternative Medicine (CAM) offers a new approach to conventional medicine. However, …

au, es (code pays fourni par la source)

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly

Haixin Zhao, Siqi Chen, Nian Cao, Wenjun Wu et autres

Abstract The mitochondrial calcium uniporter (MCU) complex mediates Ca 2+ entry into mitochondria, which plays a crucial role in regulating cellular energy metabolism and apoptosis. Dysregulation of MCU is implicated in various diseases, such as neurodegenerative disorders, cardiac diseases, and cancer. Despite …

cn (code pays fourni par la source)

In Situ Analysis of Plant Tissue Using Arc iKnife Ionization Mass Spectrometry

Wen Zheng Cai, Yuanji Gao, Changsheng Shi, Hongyue An et autres

This study developed a portable arc iKnife ionization mass spectrometry (AII-MS) technique integrating a surgical knife with low-temperature arc plasma to interact with plant tissues. The thermal energy from the arc plasma induces the sputtering of water-containing plant tissues, leading to the …

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