Eva-Maria Wagner

Polygenic risk for schizophrenia converges on alternative polyadenylation as molecular mechanism underlying synaptic impairment

Florian J. Raabe, Anna Hausruckinger, Miriam Gagliardi, Ruhel Ahmad et autres

Schizophrenia (SCZ) is a genetically heterogenous psychiatric disorder of highly polygenic nature. Correlative evidence from genetic studies indicate that the aggregated effects of distinct genetic risk factor combinations found in each patient converge onto common molecular mechanisms. To prove this on a …

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Autologous-allogeneic versus autologous tandem stem cell transplantation and maintenance therapy with thalidomide for multiple myeloma patients under 60 years of age: a prospective, phase II study

Nicolaus Martin Kröger, Gerald Georg Wulf, Ute Hegenbart, Andreas Burchert et autres

The role of autologous-allogeneic tandem stem cell transplantation (alloTSCT) followed by maintenance as upfront treatment for multiple myeloma is controversial. Between 2008 and 2014 a total of 217 multiple myeloma patients with a median age of 51 years were included by 20 …

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Itacitinib and Corticosteroids As Initial Treatment for Chronic Graft-Versus-Host Disease: Phase 1/2 Results from Gravitas-309

Annie Im, Daniel Wolff, Corey S. Cutler, Robert Zeiser et autres

Background: Itacitinib is a potent, selective oral Janus kinase (JAK) 1 inhibitor with broad anti-inflammatory activity. GRAVITAS-309 was designed as a 2-part, multicenter, randomized trial to assess the efficacy and safety of itacitinib in combination with corticosteroids (CS) as first-line treatment for …

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In Patients with Relapsed/Refractory AML Sequential Conditioning and Immediate Allogeneic Stem Cell Transplantation (allo-HCT) Results in Similar Overall and Leukemia-Free Survival Compared to Intensive Remission Induction Chemotherapy Followed By Allo-HCT: Results from the Randomized Phase III ASAP Trial

Matthias Stelljes, Jan Moritz Middeke, Gesine Bug, Eva-Maria Wagner et autres

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Das war das Pflegejahr 2021

Eva-Maria Wagner

All articles of this category Publication History Article published online: 08 February 2022 © 2022. Thieme. All rights reserved. Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany

No association of genetic variants in TLR4, TNF-α, IL10, IFN-γ, and IL37 in cytomegalovirus-positive renal allograft recipients with active CMV infection—Subanalysis of the prospective randomised VIPP study

Pascale Mazzola, Elke Schaeffeler, Oliver Witzke, Martin Nitschke et autres

BACKGROUND: Cytomegalovirus (CMV) infection is amongst the most important factors complicating solid organ transplantation. In a large prospective randomized clinical trial, valganciclovir prophylaxis reduced the occurrence of CMV infection and disease compared with preemptive therapy in CMV-positive renal allograft recipients (VIPP study; …

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Sorafenib Maintenance After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia With FLT3 –Internal Tandem Duplication Mutation (SORMAIN)

Andreas Burchert, Gesine Bug, Lea V. Fritz, Jürgen Finke et autres

PURPOSE Despite undergoing allogeneic hematopoietic stem cell transplantation (HCT), patients with acute myeloid leukemia (AML) with internal tandem duplication mutation in the FMS-like tyrosine kinase 3 gene ( FLT3-ITD) have a poor prognosis, frequently relapse, and die as a result of AML. …

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Comparison of a New Reduced Toxicity Myeloablative Treosulfan and Fludarabine Preparative Regimen with Myeloablative Busulfan or Melphalan in Combination with Fludarabine in Older Patients with Acute Myeloid Leukemia or Myelodysplastic Syndromes: A Retrospective Matched Pair Analysis of Patients from a Prospective Randomized Trial and the European Blood and Marrow Transplantation Society Registry

Dietrich Wilhelm Beelen, Simona Iacobelli, Linda Köster, Dirk-Jan Eikema et autres

Background The best preparative regimen for the growing number of older acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) patients undergoing allogeneic hematopoietic cell transplantation (HCT) from matched related (MRD) or unrelated donors (MUD) remains undefined. A large randomized phase III trial …

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Liebe Leserinnen und Leser,

Eva-Maria Wagner

All articles of this category „Ein Kind mit Berührungen zu füttern, seine Haut und seinen Rücken zu nähren, ist ebenso wichtig, wie seinen Magen zu füllen.“ Frédérick Leboyer (1918–2017), französischer Gynäkologe und Geburtshelfer die tägliche Pflege des Babys bietet eine hervorragende Gelegenheit, …

Editorial

Eva-Maria Wagner

All articles of this category „Über den eigenen Umgang mit den Kindern als Patienten und die Verarbeitung des Erlebten zu reflektieren ermöglicht jedem, ein waches, moralisches Bewusstsein und eine empathische Haltung zu entwickeln – zum Wohle der Patienten wie auch zum eigenen.“ …

Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) Are Associated with Poorer Outcome after Single Mismatch Unrelated Donor Stem Cell Transplantation: A Study of the Cooperative Transplant Study Group (KTS) of the German Group for Bone Marrow and Stem Cell Transplantation (DAG-KBT)

Francis Ayuketang Ayuk, Martin Bornhäuser, Matthias Stelljes, Tatjana Zabelina et autres

There is no established standard for selection of mismatched unrelated donors. Indirect recognition of HLA mismatches can be predicted using the model of “Predicted Indirectly ReCognizable HLA Epitopes” (PIRCHE). We performed a multicenter retrospective study evaluating the impact PIRCHE on outcome after …

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Spatial chromosome folding and active transcription drive DNA fragility and formation of oncogenic MLL translocations

Henrike Johanna Gothe, Britta A. M. Bouwman, Eduardo Gade Gusmao, Rossana Piccinno et autres

How spatial chromosome organization influences genome integrity is still poorly understood. Here we show that DNA double-strand breaks (DSBs) mediated by topoisomerase 2 (TOP2) activities, are enriched at chromatin loop anchors with high transcriptional activity. Recurrent DSBs occur at CTCF/cohesin bound sites …

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