Yongchang Chen

α-Synuclein aggregation and brain atrophy in SNCA-A53T transgenic monkeys are correlated with parkinsonism

Hongjiang Zhang, Lu Zhao, Weizhi Ji, Dingna Duan et autres

Mutations in the SNCA gene encoding α-synuclein underlie familial early-onset Parkinson’s disease. Pathological α-synuclein deposition may commence decades prior to the emergence of cardinal motor symptoms. Long-term investigation of brain and behavioural development in an SNCA-A53T transgenic macaque model offers critical insights …

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Adoptive cell therapy in lung cancer: progress, challenges, and prospects

Jingyi Li, Chan Tong, Yongchang Chen, Bo Zhu

Lung cancer is the leading cause of cancer-related deaths worldwide. Over the past decade, immunotherapy, represented by immune checkpoint inhibitors (ICIs) targeting programmed cell death protein-1/programmed cell death protein ligand-1 (PD-1/PD-L1) or cytotoxic T lymphocyte associated antigen-4 (CTLA-4), has revolutionized the treatment …

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Bridging Duchenne muscular dystrophy therapy from rhesus monkeys to patients

Wenting Guo, Weizhi Ji, Yongchang Chen

Duchenne muscular dystrophy (DMD) remains a fatal, progressive neuromuscular disease despite major advances in multidisciplinary care and genetic therapies.Its therapeutic landscape is complicated by thousands of pathogenic DMD variants and by differences in age, disease stage, muscle involvement, fibrosis, and immunity, all …

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Early gut microbial and metabolic dysregulation with subclinical cardiac alterations in a nonhuman primate model of Rett syndrome

Ting Zhang, Xiaopeng Wang, Peng Li, J Zhang et autres

Longitudinal multi-omics profiling of a nonhuman primate Rett syndrome (RTT) model reveals early systemic alterations. RTT monkeys exhibited postnatal growth retardation, intestinal structural abnormalities, and low-grade systemic inflammation. Gut microbiome analysis showed delayed microbial maturation and age-discordant dysbiosis, including altered Firmicutes/Bacteroidetes ratios …

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Growth Differentiation Factor 11 Is a Circulating Regulator of Oligodendrocyte Differentiation and CNS Myelin Formation and Repair

Z D Zhang, Min Yan, Wenjiao Huang, Yongchang Chen et autres

AIMS: Remyelination failure is a major contributor to progressive neurological disability in multiple sclerosis (MS). Although oligodendrocyte progenitor cells (OPCs) persist in demyelinated lesions, they often fail to differentiate into myelinating oligodendrocytes. This study aimed to determine whether growth differentiation factor 11 …

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Glycolytic metabolic reprogramming and mitochondrial dysfunction: A novel mechanism underlying PAEs-promoted cartilage inflammatory phenotype

Lu Liu, Yongchang Chen, Wenying Lin, Mian Zheng et autres

Phthalate esters (PAEs), the most prevalent class of plasticizers, are widely acknowledged as environmental endocrine disruptors (EDCs) and have been linked to the pathogenesis of various diseases. However, their specific role and intrinsic mechanism in inducing cartilage damage in bone-related diseases remain …

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Elimination of intramuscular immunoglobin accumulation alleviates Duchenne Muscular Dystrophy

Li Zhang, Wenting Guo, Mei Huang, Z Y Liang et autres

Abstract Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disorder due to loss of dystrophin, a cytoskeletal protein critical for muscle integrity and functionality. Despite recent therapeutic advances, there remains a significant unmet need for more effective and accessible therapeutics. Here, we …

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SCS-YOLOv8: steel surface defect detection algorithm based on improved YOLOv8n

Yongchang Chen, Dongming Xu

In order to solve the problems of insufficient target feature extraction capability and large number of model parameters faced in steel surface defect detection, this article proposes an innovative steel surface defect detection algorithm SCSYOLOv8, which is an improved version of the …

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PROFOUND CELLULAR DEFECTS ATTRIBUTE TO MUSCULAR PATHOGENESIS IN DMD RHESUS MONKEY MODEL

Ping Hu, Yongchang Chen, Weizhi Ji

Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease caused by mutations in the DMD gene. Muscle fibers rely on the coordination of multiple cell types for repair and regenerative capacity. To elucidate the cellular and molecular changes in these cell types …

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Disentangling the Switching Behavior in Functional Connectivity Dynamics in Autism Spectrum Disorder: Insights from Developmental Cohort Analysis and Molecular‐Cellular Associations

Wei Li, Xia Qiu, Jin Chen, Kexuan Chen et autres

Characterizing the transition or switching behavior between multistable brain states in functional connectivity dynamics (FCD) holds promise for uncovering the underlying neuropathology of Autism Spectrum Disorder (ASD). However, whether and how switching behaviors in FCD change in patients with developmental ASD, as …

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An SINR-Optimized AP Selection Algorithm Based on Cell-Free Massive MIMO Systems

Lin Xie, Dongming Xu, Yongchang Chen

With the rapid advancement of wireless communication technologies, cell-free massive Multiple-Input Multiple-Output (MIMO) systems have emerged as a promising solution to meet the increasing demands for high data rates and extensive coverage. However, the dense deployment of Access Points (APs) in such …

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Acacetin Attenuates Cigarette Smoke Extract-Induced Human Bronchial Epithelial Cell Injury by Activating NRF2/SLC7A11/GPX4 Signaling to Inhibit Ferroptosis

Yongchang Chen, Juan Dong, Chuanming Zhang, Jia Tang

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