α-Synuclein aggregation and brain atrophy in SNCA-A53T transgenic monkeys are correlated with parkinsonism
Hongjiang Zhang, Lu Zhao, Weizhi Ji, Dingna Duan et autres
Mutations in the SNCA gene encoding α-synuclein underlie familial early-onset Parkinson’s disease. Pathological α-synuclein deposition may commence decades prior to the emergence of cardinal motor symptoms. Long-term investigation of brain and behavioural development in an SNCA-A53T transgenic macaque model offers critical insights …
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