Yingfeng Lu

Epidemic Comparison of Ebola and Zika—the Only Two Neglected Tropical Diseases with Vertical Transmission Potential and Associated with Public Health Emergency of International Concern—among Childbearing Women

Yaoyi Wu, Xuan Lian, Jinyuan Song, Mengying Fei et autres

Background: Comparative epidemiological evidence on Ebola virus disease (EVD) and Zika virus disease (ZVD) in women of childbearing age (WCBA) is limited, hindering understanding of their mother-to-child transmission (MTCT) potential and maternal–neonatal protection. This study aimed to compare EVD and ZVD epidemiology …

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Molecular characterization and correlation with β-lactam resistance of penicillin-binding protein2x, 2b, and 1a of Streptococcus pneumoniae in clinical pneumococcal isolates

Youyi Zhang, Jiaming Shen, Feifei Hu, B L Wang et autres

Transpeptidases (TPDs), which belong to the penicillin-binding protein (PBP) families, are crucial for bacterial survival and are targeted by β-lactam antibiotics. We sought to determine the prevalence and positions of substitutions across the TPDs of the PBPs and their potential association with …

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Characterization of the intrahepatic microbiome in patients with HBV-related end-stage liver disease

Jiyang Chen, Tianzhu Liang, X Xu, Xia Yu et autres

Background Dysregulated microbiota is a hallmark of end-stage liver disease (ESLD). This study aimed to elucidate the intrahepatic microbiome in hepatitis B virus (HBV)-related ESLD.Methods We collected liver tissue samples from patients undergoing liver transplantation due to decompensated cirrhosis (DC) (n = …

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Pre‐Existing Th1 Immunity Outperforms Age in Predicting Antibody Responses to SARS‐CoV‐2 Inactivated Vaccines

Chanyuan Ye, Xiaoli Zhang, Lingfeng Qiu, Jia Ji et autres

Abstract Understanding and enhancing vaccine‐induced immune responses in the elderly population is critical, as they face elevated risks of severe COVID‐19. This work systematically delineates age‐associated alterations in innate and adaptive immunity and their impact on responses to SARS‐CoV‐2 inactivated vaccination. Compared …

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Corrigendum: FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury

Xinyu Ran, Zihan Zhou, Yuting Gu, R. Wang et autres

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Deepening Understanding of the Clinical Features and Diagnostic Approaches to Anti-Interferon-Gamma Autoantibody Associated Adult-Onset Immunodeficiency in the Last 20 Years: A Case Report and Literature Review

Liyan Zhao, Jiaojiao Ma, Ying Sun, Xiaopeng Yu et autres

Anti-interferon-gamma autoantibody (AIGA)-associated adult-onset immunodeficiency (AOID) is an emerging disease that can lead to serious opportunistic infections, which has a history of 20 years since it was first reported in 2004. It's a hard-detected AOID caused by AIGA. In recent years, there …

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Association of Ambient Temperature and Relative Humidity With Respiratory Syncytial Virus Infections Among Hospitalized Children in Suzhou, Eastern China: A Time‐Series Analysis

Yingfeng Lu, Shaolong Ren, Xuejun Shao, Jianmei Tian et autres

Respiratory syncytial virus (RSV) is the leading cause of clinical pneumonia in children. We aimed to investigate the associations between ambient temperature, relative humidity, and pediatric RSV infections, and to assess the disease burden attributable to cold or humid conditions. Daily data …

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Gut Akkerm ansia enhances liver protection and facilitates copper removal during D-penicillamine treatment in a Wilson’s disease model

Xi Huang, Yanqi Jin, Tianyuan Wang, Danting Fu et autres

ABSTRACT Patients afflicted with Wilson’s disease (WD) may encounter hepatic and extraneous manifestations due to the progressive accumulation of copper in the liver and other subsequent organs. Copper-chelating agents, such as D-penicillamine (DPA), are commonly utilized in the medical treatment of copper …

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FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury

Xinyu Ran, Zihan Zhou, Yuting Gu, R. Wang et autres

Introduction: Ferroptosis is a new type of cell death characterized by lipid peroxidation and iron dependency, representing an emerging disease regulation mechanism. The limited understanding of ferroptosis in peripheral nerve injury (PNI) complicates the management of such injuries. Mitochondrial dysfunction, which contributes …

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Plasma metabolome analysis for predicting antiviral treatment efficacy in chronic hepatitis B: diagnostic biomarkers and therapeutic insights

Deying Chen, Yingfeng Lu, Jiangshan Lian, Jiong Yu et autres

The early and accurate identification of predictive biomarkers for antiviral treatment efficacy remains a significant clinical challenge, particularly in the management of chronic hepatitis B (CHB). This study aimed to assess whether the plasma metabolome could reliably predict the success of antiviral …

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Impact of COVID‐19 Nonpharmaceutical Interventions on Respiratory Syncytial Virus Infections in Hospitalized Children

Yingfeng Lu, Qinghui Chen, Shaolong Ren, Youyi Zhang et autres

BACKGROUND: Nonpharmaceutical interventions (NPIs) targeted at SARS-CoV-2 have remarkably affected the circulation of other respiratory pathogens, including respiratory syncytial virus (RSV). This study aimed to assess the changes in epidemiological and clinical characteristics of RSV infections in hospitalized children before and during …

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Author response for "Impact of COVID‐19 Nonpharmaceutical Interventions on Respiratory Syncytial Virus Infections in Hospitalized Children"

Yingfeng Lu, Qinghui Chen, Shaolong Ren, Youyi Zhang et autres