Lucreţiu Radu

Formaldehyde in pathology services: from molecular toxicity to histopathological change and occupational risk

Mircea Sebastian Şerbănescu, Alexandra Daniela Rotaru-Zăvăleanu, Lucreţiu Radu

BACKGROUND AND OBJECTIVE: Formaldehyde (FA), classified as a Group 1 human carcinogen by the International Agency for Research on Cancer (IARC), constitutes a significant occupational hazard within hospital pathology service, where it remains the "gold standard" fixative for tissue preservation. Despite widespread …

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Serratia marcescens: A Versatile Opportunistic Pathogen with Emerging Clinical and Biotechnological Significance

Lidia Boldeanu, Mihail Virgil Boldeanu, Marius Bogdan Novac, Mohamed-Zakaria Assani et autres

Serratia marcescens is a Gram-negative opportunistic pathogen renowned for its extensive ecological versatility and clinical significance. Once considered a benign saprophyte, it has now been recognized as a notable etiological agent in nosocomial infections, predominantly affecting immunocompromised hosts. Its pathogenicity is mediated …

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Effect of COVID-19 Disease on Serum Vitamin D Status in Children with Asthma—A Retrospective Study

Jaqueline Abdul-Razzak, Mihaela Ionescu, Radu Diaconu, Alexandru Dan Popescu et autres

Background/Objectives: Vitamin D is known to decrease the risk of contracting respiratory infections and developing exacerbations for children with asthma. This research evaluates the alterations in serum vitamin D concentrations and examines lung function in children with asthma, as indicated by clinical …

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Hip osteoarthritis – histopathological aspects

Anton Tiberiu Paraliov, Răzvan Marius Vicaş, Rodica Dîrnu, Natalia Guță et autres

Osteoarthritis is a complex, degenerative disease that can affect all the anatomical structures of the synovial joints. Most frequently, the joints of the hand, hip, and knee are affected, especially in the elderly patients. In our study, we evaluated 27 femoral heads, …

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The Complex Consequences of Severe Polytrauma with Traumatic Brain Injuries Caused by a Traffic Accident in a Child: A Case Report

Liliana Anghelina, Lucreţiu Radu, Cristian Gheonea, Vlăduț Teică et autres

BACKGROUND: Polytrauma is one of the three leading causes of mortality worldwide and a major contributor to psychosocial morbidity and disability. Concomitant traumatic brain injuries further increase this risk. METHODS: We present the case of a 6-year-old child who sustained significant trauma …

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Nephrological, Pulmonary, and Dermatological Complications in the Context of MAFLD/NAFLD: A Narrative Review

Vlad Pădureanu, Dalia Dop, Lucreţiu Radu, D Rădulescu et autres

Background: The most common cause of chronic liver disease is now known to be non-alcoholic fatty liver disease (NAFLD), recently redefined as metabolic-associated fatty liver disease (MAFLD). This review aims to synthesize current evidence on the pathophysiology and clinical implications of nephrological, …

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Association Between Systemic Inflammation, Metabolic Syndrome and Quality of Life in Psoriasis Patients

Maria-Lorena Mustață, Carmen-Daniela Neagoe, Virginia Maria Rădulescu, Ioana-Gabriela Dragne et autres

BACKGROUND/OBJECTIVES: Psoriasis is a chronic inflammatory autoimmune disease with important systemic and psychosocial impacts. The association with metabolic syndrome (MS) impairs disease severity and negatively influences patient-reported outcomes, particularly their quality of life as measured by the Dermatology Life Quality Index (DLQI). …

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Correlation Between Systemic Inflammation, Metabolic Syndrome, and Quality of Life in Psoriasis Patients

Maria-Lorena Mustață, Carmen-Daniela Neagoe, Virginia Maria Rădulescu, Ioana-Gabriela Dragne et autres

Background/Objectives: Psoriasis is a chronic inflammatory autoimmune disease with important systemic and psychosocial impacts. The association with metabolic syndrome (MS) impairs disease severity and negatively influences patient-reported outcomes, particularly their quality of life as measured by the Dermatology Life Quality Index (DLQI). …

The Role of Metabolic Syndrome in Psoriasis Treatment Response: A One-Year Comparative Analysis of PASI Progression

Maria-Lorena Mustață, Mihaela Ionescu, Lucreţiu Radu, Carmen-Daniela Neagoe et autres

BACKGROUND/OBJECTIVES: Psoriasis is a chronic dermatological condition with systemic implications, especially with metabolic syndrome (MS). This study evaluated the vicious cycle where obesity and MS exacerbate systemic inflammation that complicates the efficacy of psoriasis therapies by examining the PASI score over a …

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Rare Onset of Tubercular Peritonitis Amidst Chronic Renal Dysfunction

Romeo Popa, C C Georgescu, Daniel-Cosmin Caragea, Daniela Cană-Ruiu et autres

Tuberculosis Peritonitis is a serious condition, whose diagnosis is established late due to the nonspecific nature of the clinical features, which delays the performance of imaging investigations and, implicitly, the setting of the diagnosis through biopsy and histopathological examination. We report the …

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Insulin resistance quantified by the value of HOMA‑IR and cardiovascular risk in patients with type 2 diabetes

Ionela Mihaela Vladu, Maria Forţofoiu, Diana Clenciu, Mircea-Cătălin Forțofoiu et autres

Cardiovascular disease (CVD) is recognized as a leading cause of death worldwide. Obesity, dyslipidemia, insulin resistance (IR), interconnected pathological conditions constitute risk factors that are closely associated with CVD. The aim of the present study was to highlight the association of IR …

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Analysis of Maternal and Neonatal Complications in a Group of Patients with Gestational Diabetes Mellitus

Agnesa Preda, Vlad Pădureanu, Maria Moța, Adela-Gabriela Ștefan et autres

Background and Objectives: Gestational diabetes mellitus (GDM) represents one of the most common complications during pregnancy, being associated with numerous maternal and neonatal complications. The study aimed to analyze maternal and neonatal complications associated with GDM. The risk factors of GDM and …

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