Lidia Boldeanu

Shift Work, Circadian Disruption, and Immune Dysregulation: Molecular Links to Gastrointestinal Diseases and Occupational Health Implications

Ancuța-Ramona Boicea Camen, Daniel Cosmin Caragea, Mihail Virgil Boldeanu, Dan Nicolae Florescu et autres

Shift work is an essential component of modern occupational systems but represents a major source of circadian misalignment associated with gastrointestinal symptoms and selected gastrointestinal disorders. The biological pathways underlying these associations remain incompletely integrated across circadian, neuroendocrine, immune, epithelial, and microbial …

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Contemporary Evidence on Interhospital Neonatal Transport as a Potentially Sepsis-Relevant Care Interval: A Scoping Review

Roni Octavian Damian, Lidia Boldeanu, Mihai Cucu, Mirela Anişoara Siminel et autres

Background and Objectives: Neonatal sepsis is time-sensitive, yet the role of interhospital transport in its early care pathway is poorly characterised. This scoping review systematically identified and classified contemporary neonatal transport variables, interventions, and organisational practices potentially relevant to early sepsis care, …

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Necrotizing Fasciitis of the Extremities: Microbial Spectrum, Antimicrobial Resistance, and Clinical Outcomes in a 7-Year Retrospective Cohort Study

Cosmin Vasile Obleagă, Polliana Mihaela Leru, Sergiu Marian Cazacu, Alexandru Pascu et autres

Background and Objectives: Necrotizing fasciitis (NF) is characterized by rapid and aggressive infection of the subcutaneous tissue and fascia, and a high risk of death in case of delay in diagnosis and treatment. Materials and Methods: This 7-year retrospective study (May 2017–May …

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Atopic Dermatitis and Bone Fragility: Osteoimmunological Pathways, Therapeutic Paradoxes, and Risk-Adapted Screening Across the Lifespan

Ancuța-Ramona Boicea Camen, Mohamed-Zakaria Assani, Rodica Pădureanu, George Mitroi et autres

Background/Objectives: Atopic dermatitis (AD) has been associated with osteoporosis and fractures, but the magnitude, mechanisms, therapeutic implications, and clinical relevance of this relationship remain uncertain. This review critically evaluates the epidemiological and osteoimmunological evidence linking AD to skeletal fragility and proposes a …

From Occupational Exposure to Bone Fragility: Toward Precision Occupational Medicine in Osteoporosis Prevention

Ancuța-Ramona Boicea Camen, Mohamed-Zakaria Assani, Alexandra-Ştefania Stroe-Ionescu, Isabela Siloși et autres

Background/Objectives: Osteoporosis is a major cause of skeletal fragility, yet occupational determinants of bone health remain comparatively underrecognized in clinical and occupational medicine. This review aimed to critically evaluate the relationships between occupational exposures and skeletal health, examine the biological mechanisms potentially …

Prognostic Significance of Oxidative Stress Biomarkers and Novel Hematological Inflammatory Indices in Colorectal Cancer: A Prospective Observational Study

Răzvan Alexandru Marinescu, Daniela Marinescu, Ana-Maria Ciurea, Lidia Boldeanu et autres

Background and Objectives: Oxidative stress and chronic inflammation are closely interconnected processes involved in colorectal cancer (CRC) development and progression. However, the relationships between oxidative stress biomarkers, emerging hematological inflammatory indices, clinicopathological characteristics, and survival outcomes remain insufficiently characterized. This study evaluated …

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Dynamic Inflammatory and Erythrocyte-Derived Biomarkers in Newly Diagnosed Multiple Myeloma: A Longitudinal Analysis of Classical and Novel Indices

Alexandra-Ştefania Stroe-Ionescu, Lidia Boldeanu, Ana Maria Pătraşcu, J. G. Goanta et autres

Background/Objectives: Inflammatory and hematologic indices derived from routine blood tests have been increasingly investigated as prognostic biomarkers in multiple myeloma (MM). However, their clinical utility remains inconsistent, and data on novel composite indices, such as the mean corpuscular volume-to-lymphocyte ratio (MCVL) and …

Shift Work, Circadian Disruption, and Immune Dysregulation: Molecular Links to Gastrointestinal Diseases and Occupational Health Implications

Ancuța-Ramona Boicea Camen, Daniel Cosmin Caragea, Mihail Virgil Boldeanu, Mohamed-Zakaria Assani et autres

Background/Objectives: Shift work is an essential component of modern occupational systems but represents a major source of chronic circadian disruption associated with adverse gastrointestinal outcomes. The biological pathways underlying these associations remain incompletely integrated across circadian, neuroendocrine, immune, epithelial, and microbial domains. …

Gut Microbiome-Driven Strategies to Overcome Immunotherapy Resistance in Microsatellite-Stable Colorectal Cancer

Lidia Boldeanu, Alice Elena Ghenea, Alina Elena Ciobanu Plasiciuc, Mihail Virgil Boldeanu et autres

BACKGROUND/OBJECTIVES: Microsatellite-stable colorectal cancer (MSS CRC) accounts for the vast majority of CRC cases and remains largely resistant to immune checkpoint inhibitors. Emerging evidence suggests that the gut microbiome is an important regulator of antitumor immunity and may contribute to immunotherapy resistance …

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Gut Microbiome Dysbiosis in Atopic Dermatitis: Pathogenic Mechanisms, Gut–Skin Axis Disruption, and Emerging Microbiota-Targeted Therapies

Lidia Boldeanu, Alice Elena Ghenea, Marius Bogdan Novac, Virgilios Galatis et autres

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by epidermal barrier dysfunction, immune dysregulation, and marked clinical heterogeneity. Growing evidence implicates the gut microbiome in AD-related pathways through microbial metabolites, intestinal barrier function, and systemic immune signaling. This narrative review …

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Atopic Dermatitis Beyond the Skin Barrier: Precision Medicine Approaches to Immunological Profiling and Therapeutic Innovation

Virgilios Galatis, Isabela Siloşi, Mohamed-Zakaria Assani, Lidia Boldeanu et autres

Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease characterized by substantial clinical and immunological heterogeneity. Once considered primarily a disorder of epidermal barrier dysfunction, AD is now recognized as a complex systemic inflammatory condition involving dysregulated immune responses, epithelial-derived signaling, …

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Cutaneous Staphylococcus aureus Infections in Renal Edema Across Kidney Disease and the Intensive Care Unit: Pathophysiological Mechanisms, Clinical Implications, and Therapeutic Challenges

Mariana-Emilia Caragea, Daniel Cosmin Caragea, Marius Bogdan Novac, Lidia Boldeanu et autres

Staphylococcus aureus, particularly methicillin-resistant S. aureus (MRSA), remains a leading cause of skin and soft tissue infections (SSTIs) worldwide. Patients with renal edema, including those with nephrotic syndrome and chronic kidney disease (CKD), and critical illness, are particularly susceptible because of barrier …

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