Marta S. Smith

Morning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action

Hannah L. Waterman, Marta S. Smith, Ben Farmer, Kalisha Yankey et autres

The second-meal phenomenon refers to the improved glycemic response to a subsequent identical meal. We previously showed that morning hyperinsulinemia is a key mediator, priming the liver for enhanced net hepatic glucose uptake (NHGU) and glycogen storage during an afternoon hyperinsulinemic-hyperglycemic clamp. …

us (code pays fourni par la source)

Morning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action

Hannah L. Waterman, Marta S. Smith, Ben Farmer, Kalisha Yankey et autres

The second-meal phenomenon refers to the improved glycemic response to a subsequent identical meal. We previously showed that morning (AM) hyperinsulinemia is a key mediator, priming the liver for enhanced net hepatic glucose uptake (NHGU) and glycogen storage during an afternoon (PM) …

Morning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action

Hannah L. Waterman, Marta S. Smith, Ben Farmer, Kalisha Yankey et autres

The second-meal phenomenon refers to the improved glycemic response to a subsequent identical meal. We previously showed that morning (AM) hyperinsulinemia is a key mediator, priming the liver for enhanced net hepatic glucose uptake (NHGU) and glycogen storage during an afternoon (PM) …

Morning glucagon disrupts insulin induced hepatic metabolic memory and subsequent afternoon glucose metabolism in canines

Hannah L. Waterman, Marta S. Smith, Ben Farmer, Kalisha Yankey et autres

Introduction: The Staub-Traugott effect, or second-meal phenomenon, describes improved glucose disposal after a second identical meal. We previously showed that morning hyperinsulinemia primes the liver to enhance afternoon net hepatic glucose uptake and glycogen storage. However, mixed meals trigger co-secretion of insulin …

us (code pays fourni par la source)

Morning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action

Hannah L. Waterman, Marta S. Smith, Ben Farmer, Kalisha Yankey et autres

Abstract The second-meal phenomenon refers to the improved glycemic response to a subsequent identical meal. We previously showed that morning (AM) hyperinsulinemia is a key mediator, priming the liver for enhanced net hepatic glucose uptake (NHGU) and glycogen storage during an afternoon …

us (code pays fourni par la source)

362-OR: Morning Elevation in Insulin Enhances Afternoon Postprandial Insulin Action and Glucose Effectiveness

Hannah L. Waterman, Marta S. Smith, Kalisha Yankey, BEN FARMER et autres

Introduction and Objective: The 2nd meal phenomenon refers to the improved glycemic response observed after consuming a 2nd identical meal. It is well known that postprandial hepatic glucose uptake (HGU) is determined by the combined effects of three regulatory factors: insulin action …

us (code pays fourni par la source)

Morning Glucagon Disrupts Insulin Induced Hepatic Metabolic Memory and Subsequent Afternoon Glucose Metabolism in Canines

Hannah L. Waterman, Marta S. Smith, Ben Farmer, Kalisha Yankey et autres

The second meal effect describes an improved glycemic response observed after consuming a second identical meal. We previously showed that morning (AM) exposure to hyperinsulinemia primes the liver for enhanced hepatic glucose uptake and glycogen storage in the afternoon (PM), with no …

us (code pays fourni par la source)

Improved Afternoon Hepatic Glucose Disposal and Storage Requires Morning Engagement of Hepatic Insulin Receptors

Hannah L. Waterman, Mary Courtney Moore, Marta S. Smith, Ben Farmer et autres

Glucose tolerance improves significantly upon consuming a second, identical meal later in the day (second-meal phenomenon). We previously established that morning hyperinsulinemia primes the liver for increased afternoon hepatic glucose uptake (HGU). Although the route of insulin delivery is an important determinant …

us (code pays fourni par la source)

Improved Afternoon Hepatic Glucose Disposal and Storage Requires Morning Engagement of Hepatic Insulin Receptors

Hannah L. Waterman, Mary Courtney Moore, Marta S. Smith, Ben Farmer et autres

Glucose tolerance improves significantly upon consuming a second, identical meal later in the day (second meal phenomenon). We previously established that morning hyperinsulinemia primes the liver for increased afternoon hepatic glucose uptake (HGU). Although the route of insulin delivery is an important …

Improved Afternoon Hepatic Glucose Disposal and Storage Requires Morning Engagement of Hepatic Insulin Receptors

Hannah L. Waterman, Mary Courtney Moore, Marta S. Smith, Ben Farmer et autres

Glucose tolerance improves significantly upon consuming a second, identical meal later in the day (second meal phenomenon). We previously established that morning hyperinsulinemia primes the liver for increased afternoon hepatic glucose uptake (HGU). Although the route of insulin delivery is an important …

Morning Engagement of Hepatic Insulin Receptors Improves Afternoon Hepatic Glucose Disposal and Storage

Hannah L. Waterman, Mary Courtney Moore, Marta S. Smith, Ben Farmer et autres

Abstract Glucose tolerance improves significantly upon consuming a second, identical meal later in the day (second meal phenomenon). We previously established that morning hyperinsulinemia primes the liver for increased afternoon hepatic glucose uptake (HGU). Although the route of insulin delivery is an …

us (code pays fourni par la source)

Duration of morning hyperinsulinemia determines hepatic glucose uptake and glycogen storage later in the day

Hannah L. Waterman, Marta S. Smith, Ben Farmer, Melanie J. Scott et autres

Morning insulin exposure primes the liver for increased hepatic glucose uptake and glycogen storage during a subsequent hyperinsulinemic-hyperglycemic clamp. This study addressed whether the pattern and/or duration of insulin delivery in the morning influences insulin's ensuing priming effect. We found that despite …

us (code pays fourni par la source)