Hannah L. Waterman

Morning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action

Hannah L. Waterman, Marta S. Smith, Ben Farmer, Kalisha Yankey et autres

The second-meal phenomenon refers to the improved glycemic response to a subsequent identical meal. We previously showed that morning hyperinsulinemia is a key mediator, priming the liver for enhanced net hepatic glucose uptake (NHGU) and glycogen storage during an afternoon hyperinsulinemic-hyperglycemic clamp. …

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Morning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action

Hannah L. Waterman, Marta S. Smith, Ben Farmer, Kalisha Yankey et autres

The second-meal phenomenon refers to the improved glycemic response to a subsequent identical meal. We previously showed that morning (AM) hyperinsulinemia is a key mediator, priming the liver for enhanced net hepatic glucose uptake (NHGU) and glycogen storage during an afternoon (PM) …

Morning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action

Hannah L. Waterman, Marta S. Smith, Ben Farmer, Kalisha Yankey et autres

The second-meal phenomenon refers to the improved glycemic response to a subsequent identical meal. We previously showed that morning (AM) hyperinsulinemia is a key mediator, priming the liver for enhanced net hepatic glucose uptake (NHGU) and glycogen storage during an afternoon (PM) …

Morning glucagon disrupts insulin induced hepatic metabolic memory and subsequent afternoon glucose metabolism in canines

Hannah L. Waterman, Marta S. Smith, Ben Farmer, Kalisha Yankey et autres

Introduction: The Staub-Traugott effect, or second-meal phenomenon, describes improved glucose disposal after a second identical meal. We previously showed that morning hyperinsulinemia primes the liver to enhance afternoon net hepatic glucose uptake and glycogen storage. However, mixed meals trigger co-secretion of insulin …

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Supplemental Materials and Supporting Data Values File for "Morning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action" submitted to Diabetes 2026.

Hannah L. Waterman

Supporting files for "Morning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action" by Waterman, HL et. al.

Supplemental Materials and Supporting Data Values File for

Hannah L. Waterman

Supporting files for "Morning Elevation in Insulin Enhances Afternoon Postprandial Glucose Action and Insulin Action in Canines" by Waterman, HL et. al.

Supplemental Materials and Supporting Data Values File for "Morning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action" submitted to Diabetes 2026.

Hannah L. Waterman

Supporting files for "Morning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action" by Waterman, HL et. al.

Supplemental Materials and Supporting Data Values File for "Morning Elevation in Insulin Enhances Afternoon Postprandial Glucose Action and Insulin Action in Canines"

Hannah L. Waterman

Supporting files for "Morning Elevation in Insulin Enhances Afternoon Postprandial Glucose Action and Insulin Action in Canines" by Waterman, HL et. al.

Morning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action

Hannah L. Waterman, Marta S. Smith, Ben Farmer, Kalisha C Yankey et autres

Abstract The second-meal phenomenon refers to the improved glycemic response to a subsequent identical meal. We previously showed that morning (AM) hyperinsulinemia is a key mediator, priming the liver for enhanced net hepatic glucose uptake (NHGU) and glycogen storage during an afternoon …

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362-OR: Morning Elevation in Insulin Enhances Afternoon Postprandial Insulin Action and Glucose Effectiveness

Hannah L. Waterman, Marta S. Smith, Kalisha C Yankey, BEN FARMER et autres

Introduction and Objective: The 2nd meal phenomenon refers to the improved glycemic response observed after consuming a 2nd identical meal. It is well known that postprandial hepatic glucose uptake (HGU) is determined by the combined effects of three regulatory factors: insulin action …

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Morning Glucagon Disrupts Insulin Induced Hepatic Metabolic Memory and Subsequent Afternoon Glucose Metabolism in Canines

Hannah L. Waterman, Marta S. Smith, Ben Farmer, Kalisha C Yankey et autres

The second meal effect describes an improved glycemic response observed after consuming a second identical meal. We previously showed that morning (AM) exposure to hyperinsulinemia primes the liver for enhanced hepatic glucose uptake and glycogen storage in the afternoon (PM), with no …

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Improved Afternoon Hepatic Glucose Disposal and Storage Requires Morning Engagement of Hepatic Insulin Receptors

Hannah L. Waterman, Mary Courtney Moore, Marta S. Smith, Ben Farmer et autres

Glucose tolerance improves significantly upon consuming a second, identical meal later in the day (second-meal phenomenon). We previously established that morning hyperinsulinemia primes the liver for increased afternoon hepatic glucose uptake (HGU). Although the route of insulin delivery is an important determinant …

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