Fanrong Kong

Sinomenine hydrochloride ameliorates fatty acid–induced bovine mammary epithelial cells' oxidative stress and inflammation via enhancing autophagy activity

Jin‐xia Li, Xiliang Du, De‐Fang Qi, Menglin Liu et autres

During the transition period, dairy cows often experience negative energy balance (NEB), leading to excessive mobilization of adipose tissue and elevated circulating nonesterified fatty acids (NEFA). These excess NEFA can be taken up by the mammary gland, triggering redox imbalances and pro-inflammatory …

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The role of glutathione S-transferase mu 2 in mitigating fatty acid–induced hepatic inflammation in dairy cows

Jinxia Li, Chenchen Zhao, Dandan Qi, Fanrong Kong et autres

Fatty liver is a major metabolic disorder in perinatal dairy cows, characterized by elevated plasma concentrations of nonesterified fatty acids (NEFA) and hepatic inflammation. Glutathione S-transferase mu 2 (GSTM2), a phase II detoxification enzyme, regulates cellular antioxidant and detoxification processes in nonruminants. …

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Hypoxia-inducible factor 2α mediates nonesterified fatty acids and hypoxia-induced lipid accumulation in bovine hepatocytes

Fanrong Kong, Lin Lei, Lin Cai, Jinxia Li et autres

Ketosis is a metabolic disorder frequently occurring in the perinatal period, characterized by elevated circulating concentrations of nonesterified fatty acids (NEFA) due to negative energy balance, resulting in fatty liver in dairy cows. However, the mechanism of hepatic steatosis induced by high …

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Design of Sports Equipment and Facilities Maintenance and Management System Based on PSO-SVM and DIALux

Fanrong Kong, Guangpeng Li

With the continuous progress and development of science and technology, people are paying more and more attention to sports. In modern society, sports are a very important component. Sports equipment and facilities are often referred to as hardware resources or software resources, …

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CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium

Yanhua Lv, Yanqing Liu, Yueqiang Wang, Fanrong Kong et autres

BACKGROUND: This study aimed to explore the molecular mechanisms of tibolone treatment in postmenopausal women. METHODS: The gene set enrichment profile, GSE12446, which includes 9 human endometrial samples from postmenopausal women treated with tibolone (tibolone group) and 9 control samples (control group), …

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Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor

Zizheng Zou, Xiyuan Hu, Tiao Luo, Zhengnan Ming et autres

Argininosuccinate synthase (ASS1) is a ubiquitous enzyme in mammals that catalyzes the formation of argininosuccinate from citrulline and aspartate. ASS1 genetic deficiency in patients leads to an autosomal recessive urea cycle disorder citrullinemia, while its somatic silence or down-regulation is very common …

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Additional file 6 of CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium

Yanhua Lv, Yanqing Liu, Yueqiang Wang, Fanrong Kong et autres

Additional file 6: Table S5. Validation of the predictive drugs in Pubmed.

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Additional file 2 of CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium

Yanhua Lv, Yanqing Liu, Yueqiang Wang, Fanrong Kong et autres

Additional file 2: Table S1. The enriched biological processes terms and KEGG pathways for DEGs.

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Additional file 5 of CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium

Yanhua Lv, Yanqing Liu, Yueqiang Wang, Fanrong Kong et autres

Additional file 5: Table S4. The obtained drug-gene interactions information from GDIdb database.

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Additional file 4 of CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium

Yanhua Lv, Yanqing Liu, Yueqiang Wang, Fanrong Kong et autres

Additional file 4: Table S3. The enriched GO terms and KEGG pathways for genes in significant modules identified from PPI network.

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Additional file 3 of CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium

Yanhua Lv, Yanqing Liu, Yueqiang Wang, Fanrong Kong et autres

Additional file 3: Table S2. Results of topological properties analysis for nodes in PPI network.

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Dryocrassin ABBA ameliorates Streptococcus pneumoniae-induced infection in vitro through inhibiting Streptococcus pneumoniae growth and neutralizing pneumolysin activity

Hongfa Lv, Tianqi Fang, Fanrong Kong, Jianfeng Wang et autres

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