Christine Pérot

Cytogenetics in the management of children and adult acute lymphoblastic leukemia (ALL): an update by the Groupe francophone de cytogénétique hématologique (GFCH)

Laurence Baranger, Wendy Cuccuini, Christine Lefebvre, Isabelle Luquet et autres

Cytogenetic analyses (karyotype and, if necessary, appropriate complementary FISH analyses) are mandatory at diagnosis in acute lymphoblastic leukemia (ALL) as their results are taken into account in therapeutic protocols due to their diagnostic and prognostic values. In some cases, karyotype can be …

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disorder and predisposition to leukemia in children SPRED1

Judith Landman‐Parker, Éric Pasmant, Paola Ballerini, Hélène Lapillonne et autres

Interest of cytogenetic and FISH evaluation for prognosis evaluation in 198 patients with acute myeloid leukemia in first complete remission in a single institution

Pierre Hirsch, Myriam Labopin, F Viguié, Christine Pérot et autres

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t(6;9)(p22;q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients

Julie Damgaard Sandahl, Eva A. Coenen, Erik Forestier, Jochen Harbott et autres

Acute myeloid leukemia with t(6;9)(p22;q34) is listed as a distinct entity in the 2008 World Health Organization classification, but little is known about the clinical implications of t(6;9)-positive myeloid leukemia in children. This international multicenter study presents the clinical and genetic characteristics …

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Neurofibromatosis‐1 gene deletions and mutations in de novo adult acute myeloid leukemia

Elise Boudry‐Labis, Catherine Roche‐Lestienne, Olivier Nibourel, Nicolas Boissel et autres

Germline heterozygous alterations of the tumor-suppressor gene neurofibromatosis-1 (NF1) lead to neurofibromatosis type 1, a genetic disorder characterized by a higher risk to develop juvenile myelomonocytic leukemia and/or acute myeloid leukemia (AML). More recently, somatic 17q11 deletions encompassing NF1 have been described …

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Translocation t(6;9)(p22;q34)/DEK-NUP214 rearranged Pediatric AML: A Retrospective International Study

Julie Damgaard Sandahl, Eva A. Coenen, Erik Forestier, Jochen Harbott et autres

Abstract Abstract 538 The cytogenetic subgroup t(6;9)(p22;q34), previously often reported as a breakpoint in 6p23, is defined as a distinct entity in the 2008 WHO classification of acute myeloid leukemia (AML). The translocation results in a chimeric fusion between DEK at 6p22.3 …

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RET fusion genes are associated with chronic myelomonocytic leukemia and enhance monocytic differentiation

Paola Ballerini, Stéphanie Struski, Charlotte Cresson, Naïs Prade et autres

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Classification of and risk factors for hematologic complications in a French national cohort of 102 patients with Shwachman-Diamond syndrome

Jean Donadieu, Odile Fenneteau, Blandine Beaupain, Sandrine Beaufils et autres

BACKGROUND: Patients with the Shwachman-Diamond syndrome often develop hematologic complications. No risk factors for these complications have so far been identified. The aim of this study was to classify the hematologic complications occurring in patients with Shwachman-Diamond syndrome and to investigate the …

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Interest of the Association Azacitidine-Lenalidomide As Front Line Therapy in High-Risk Myelodysplasia (MDS) or Acute Myeloid Leukemia (AML) with Complex Karyotype

Elodie Scherman, Sandra Malak, Christine Pérot, Norbert Claude Gorin et autres

Abstract Abstract 5035 Background. Results of intensive chemotherapy (ICT) in myelodysplasia (MDS) or secondary acute myeloid leukaemia (sAML) are poor, particularly in the presence of complex cytogenetic. Allogeneic haematopoietic stem cell transplantation (HSCT) remains the only curative treatment but only a minority …

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t(8;20)(p11;q13)

Julien Mozziconacci, Christine Pérot

Interest of the association azacitidine–lenalidomide as frontline therapy in high-risk myelodysplasia or acute myeloid leukemia with complex karyotype

Elodie Scherman, Sandra Malak, Christine Pérot, Norbert Claude Gorin et autres

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Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study

Eva A. Coenen, Susana C. Raimondi, Jochen Harbott, Martin Zimmermann et autres

We previously demonstrated that outcome of pediatric 11q23/MLL-rearranged AML depends on the translocation partner (TP). In this multicenter international study on 733 children with 11q23/MLL-rearranged AML, we further analyzed which additional cytogenetic aberrations (ACA) had prognostic significance. ACAs occurred in 344 (47%) …

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