Ivan Peng

Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury

Kimberly L. Stark, Tatiana Goncharov, Eugene E. Varfolomeev, Luke Xie et autres

RIP1 kinase-mediated inflammatory and cell death pathways have been implicated in the pathology of acute and chronic disorders of the nervous system. Here, we describe a novel animal model of RIP1 kinase deficiency, generated by knock-in of the kinase-inactivating RIP1(D138N) mutation in …

IL-17A is associated with the breakdown of the blood-brain barrier in relapsing-remitting multiple sclerosis

A. Francesca Setiadi, Alexander R. Abbas, Surinder Jeet, Kit Hong Wong et autres

IL-17 has been implicated in the pathogenesis of multiple sclerosis (MS). Here, we show that blockade of IL-17A, but not IL-17F, attenuated experimental autoimmune encephalomyelitis (EAE). We further show that IL-17A levels were elevated in the CSF of relapsing-remitting MS (RRMS) patients …

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Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma

Hart S. Dengler, Xiumin Wu, Ivan Peng, Cornelia H. Rinderknecht et autres

Preclinical and clinical evidence indicates that a subset of asthma is driven by type 2 cytokines such as interleukin-4 (IL-4), IL-5, IL-9, and IL-13. Additional evidence predicts pathogenic roles for IL-6 and type I and type II interferons. Because each of these …

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Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes

Teresita L. Arenzana, Steve Lianoglou, Akiko Seki, Céline Eidenschenk et autres

(H3K27me3). Deletion of BAP1 also abrogated B cell development in the bone marrow. Our findings uncover a nonredundant function for BAP1 in maintaining the lymphoid lineage.

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Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling

Mohammad Samie, Junghyun Lim, Erik Verschueren, Joshua M. Baughman et autres

Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins

Alexandra M. Whiteley, Miguel A. Prado, Ivan Peng, Alexander R. Abbas et autres

Ubiquilins (Ubqlns) are a family of ubiquitin receptors that promote the delivery of hydrophobic and aggregated ubiquitinated proteins to the proteasome for degradation. We carried out a proteomic analysis of a B cell lymphoma-derived cell line, BJAB, that requires UBQLN1 for survival …

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Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model

Jun Liang, Anne van Abbema, Mercedesz Balázs, Kathy Barrett et autres

Author response: Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins

Alexandra M. Whiteley, Miguel A. Prado, Ivan Peng, Alexander R. Abbas et autres

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The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation

Kate Senger, Victoria C. Pham, Eugene E. Varfolomeev, Jason A. Hackney et autres

Tumor progression locus 2 (TPL2; also known as MAP3K8) is a mitogen-activated protein kinase (MAPK) kinase kinase (MAP3K) that phosphorylates the MAPK kinases MEK1 and MEK2 (MEK1/2), which, in turn, activate the MAPKs extracellular signal-regulated kinase 1 (ERK1) and ERK2 (ERK1/2) in …

CXCL14 is a candidate biomarker for Hedgehog signalling in idiopathic pulmonary fibrosis

Guiquan Jia, Sanjay J. Chandriani, Alexander R. Abbas, Daryle J. DePianto et autres

Background Idiopathic pulmonary fibrosis (IPF) is associated with aberrant expression of developmental pathways, including Hedgehog (Hh). As Hh signalling contributes to multiple pro-fibrotic processes, Hh inhibition may represent a therapeutic option for IPF. However, no non-invasive biomarkers are available to monitor lung …

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Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

Eugene Y. Chiang, Tianbo Li, Surinder Jeet, Ivan Peng et autres

channels expressed by human and rat T cells. Despite the preferential upregulation of Kv1.3 over KCa3.1 on autoantigen-experienced effector memory T cells, whether Kv1.3 is required for their induction and function is unclear. Here we show, using Kv1.3-deficient rats, that Kv1.3 is …

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Ubiquilin1 is uniquely required for cell cycle entry and proliferation downstream of B-cell receptor signaling.

Alexandra M. Greer, Alexander R. Abbas, Benjamin Haley, Ivan Peng et autres

Abstract Ubiquilins are a family of ubiquitin-like proteins thought to be chaperones for proteasome-bound ubiquitinated substrates. Recently, ubiquilins have been implicated in neurodegenerative disease, as UBQLN2 mutations cause ALS in some humans and variants in the ubiquitously expressed UBQLN1 have been associated …

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