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Malgorzata Grzelka, Rehman Khawaja, Alejandro J. Brenes, Daniel Dugger et autres
Malgorzata Grzelka, William A. Cambridge, Guiquan Jia, Dario Nicetto et autres
Sarah Esther Chang, Guiquan Jia, Xia Gao, Courtney Schiffman et autres
INTRODUCTION: Pulmonary fibrosis is a characteristic of various interstitial lung diseases (ILDs) with differing etiologies. Clinical trials in progressive pulmonary fibrosis (PPF) enroll patients based on previously described clinical criteria for past progression, which include a clinical practice guideline for PPF classification …
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Tianhe Sun, Jason A. Vander Heiden, Xia Gao, Jianping Yin et autres
BACKGROUND: Transforming growth factor β (TGF-β) is implicated as a key mediator of pathological fibrosis, but its pleiotropic activity in a range of homeostatic functions presents challenges to its safe and effective therapeutic targeting. There are three isoforms of TGF-β, TGF-β1, TGF-β2, …
Guiquan Jia, Thirumalai R. Ramalingam, Jason A. Vander Heiden, Xia Gao et autres
Systemic sclerosis (SSc) interstitial lung disease (ILD) is among the leading causes of SSc-related morbidity and mortality. Tocilizumab (TCZ, anti-IL6RA) has demonstrated a reduced rate of pulmonary function decline in two phase 2/3 trials (faSScinate and focuSSced) in SSc-ILD patients. We performed …
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Margaret Neighbors, Qingling Li, Sha Zhu, Jia Liu et autres
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with significant mortality. Prognostic biomarkers to identify rapid progressors are urgently needed to improve patient management. Since the lysophosphatidic acid (LPA) pathway has been implicated in lung fibrosis in preclinical models and identified as …
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Taha Al‐Shaikhly, Ryan C. Murphy, Ying Lai, Charles W. Frevert et autres
Accurate phenotypic and endotypic characterization of asthma is critical to inform treatment decisions, particularly for patients with eosinophilic or type-2 (T2) high asthma who are more responsive to inhaled corticosteroids and are candidates for biologic therapies targeting T2 inflammation.1 Current biomarkers of …
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Ying Xi, Ryan LaCanna, Hsiao‐Yen Ma, Elsa-Noah N’Diaye et autres
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Janet K. Jackman, Amy Stockwell, David F. Choy, Markus Ming Xie et autres
BACKGROUND: Clinical studies of type 2 (T2) cytokine-related neutralizing antibodies in asthma have identified a substantial subset of patients with low levels of T2 inflammation who do not benefit from T2 cytokine neutralizing antibody treatment. Non-T2 mechanisms are poorly understood in asthma …
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Ying Xi, Ryan LaCanna, Elsa-Noah N’Diaye, Sarah Gierke et autres
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Xia Gao, Guiquan Jia, Anna Guttman, Daryle J. DePianto et autres
Progressive lung fibrosis is a major cause of mortality in systemic sclerosis (SSc) patients, but the underlying mechanisms remain unclear. We demonstrate that immune complexes (ICs) activate human monocytes to promote lung fibroblast migration partly via osteopontin (OPN) secretion, which is amplified …
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Henry R. Maun, Janet K. Jackman, David F. Choy, Kelly M. Loyet et autres
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