Yiming You

Dihydroartemisinin alleviates pulmonary fibrosis by modulating the calcium signaling pathway in fibroblasts

Caihong Luo, Zhiyong Zou, Zili Zhou, Cuiwen Wu et autres

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, irreversible interstitial lung disease with limited effective treatment options. Dihydroartemisinin (DHA), a water-soluble derivative of artemisinin primarily known for its antimalarial properties, has shown potential antifibrotic effects, although its mechanisms remain unclear. PURPOSE: …

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Biological relationship between Parkinson's disease and gallstone disease

Jingying Ma, Jingyu Mu, Yuanyuan Fu, Yan Zhao et autres

Compelling evidence indicates a significant connection between dysfunction of the gastrointestinal tract, the gut microbiome, and Parkinson's disease (PD), which aligns with the notion of the "gut-brain axis". While the exact mechanisms involved in gut-brain interactions are still not fully understood, the …

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Exploratory Single-Cell Transcriptomic Profiling Reveals Dysregulated Glial Populations and Pathways in Focal Cortical Dysplasia Epilepsy

Chao Qiang Jiang, Yan Zhao, Yiming You, Jian Wang et autres

BACKGROUND: Focal cortical dysplasia (FCD) is a prevalent cause of drug-resistant epilepsy, but a comprehensive understanding of its pathogenesis at a cellular resolution remains limited. Previous transcriptomic studies, often constrained by bulk tissue analysis, have been unable to dissect the cell-type-specific contributions …

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Astrocytic lactoferrin deficiency augments MPTP-induced dopaminergic neuron loss by disturbing glutamate/calcium and ER-mitochondria signaling

Shuangfeng Xu, Jun-He Cui, Xin Liu, Zhongqiu Pang et autres

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