Yan Zhao

Green-Extracted Ficus carica L. Fruit Polysaccharides Promote Longevity in Caenorhabditis elegans via Modulation of SKN-1 and IIS Pathway

Lianyu Li, Feng Ding, Yong Sheng, Yan Zhao

In this study, polysaccharides from Ficus carica L. fruits (FCPs) were extracted using a deep eutectic solvent (DES)-based ultrasound-assisted extraction (UAE) method. The physicochemical properties of the FCPs were then characterized, and the anti-aging effects of FCPs were evaluated in Caenorhabditis elegans …

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Biological relationship between Parkinson's disease and gallstone disease

Jingying Ma, Jingyu Mu, Yuanyuan Fu, Yan Zhao et autres

Compelling evidence indicates a significant connection between dysfunction of the gastrointestinal tract, the gut microbiome, and Parkinson's disease (PD), which aligns with the notion of the "gut-brain axis". While the exact mechanisms involved in gut-brain interactions are still not fully understood, the …

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Exploratory Single-Cell Transcriptomic Profiling Reveals Dysregulated Glial Populations and Pathways in Focal Cortical Dysplasia Epilepsy

Chao Jiang, Yan Zhao, Yiming You, Jian Wang et autres

BACKGROUND: Focal cortical dysplasia (FCD) is a prevalent cause of drug-resistant epilepsy, but a comprehensive understanding of its pathogenesis at a cellular resolution remains limited. Previous transcriptomic studies, often constrained by bulk tissue analysis, have been unable to dissect the cell-type-specific contributions …

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Gestational exposure to TDCIPP disrupts embryonic development via LEPR-mediated IL6/JAK2/STAT3 signaling pathway in mice

Yongbo Zhao, Hanyu Rao, Ping Qiao, Yan Zhao et autres

Organophosphate esters (OPEs) are widely used flame retardants that have become ubiquitous in the environment. As typical environmental endocrine disruptors (EEDs), their adverse effects on human reproduction and development have raised global concern. In this study, we assessed the embryotoxicity of tris …

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Targeting DDX3X suppresses progression of KRAS-driven lung cancer by disrupting antioxidative homeostasis and inducing ferroptosis

Meijuan Dian, Qingyu Meng, Songwen Lin, Ming Ji et autres

Abstract Approximately 30% of human cancers carry various RAS mutations, including KRAS, NRAS, and HRAS. Among these mutations, KRAS is the most prevalent isoform detected in lung cancer. While several small molecular inhibitors targeting specifically KRAS G12C have been developed and tested …

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Gold nanostars-driven SERS biosensors for fingerprinting detection and quantitative profiling of anabolic steroids

Ziji Oubu, Rui Tan, 絹代 鈴木, Tao Yang et autres

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Ventilator-induced Lung Injury Associated With Endothelial Cell Mitochondrial Fission

Marissa D. Pokharel, Georgios D. Kitsios, Panfeng Fu, Alejandro Garcia Flores et autres

Abstract RATIONALE: Mechanical ventilation (MV) represents a cornerstone of supportive care for sepsis-induced acute respiratory distress syndrome. Unfortunately, cyclic positive pressure from MV can exacerbate lung injury, a phenomenon known as ventilator-induced lung injury (VILI). Recent studies highlight the crucial role of …

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Modeling the Interaction of Cytotoxic T-Lymphocytes and Oncolytic Viruses in a Tumor Microenvironment

Yan Zhao, Qi Deng, Zhipeng Qiu, Ting Guo et autres

Abstract. Oncolytic virotherapy has become a promising approach in treating cancer. Understanding the mechanism of interaction between oncolytic viruses (OVs) and the immune system is crucial for the interventional diagnosis and therapy of tumors. In this paper, a mathematical model is formulated …

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Association between mixed exposure of phenols, parabens, phthalates and cognitive function in US elders

H.F. Du, Qingxia Wang, Yiru Chen, Xinyue Wu et autres

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[Advance on risk factors of occupational carpal tunnel syndrome].

Yan Zhao, Yan Zheng, Li Guan

Carpal tunnel syndrome is the most common peripheral nerve compression syndrome and a well-studied form of nerve entrapment syndrome as well. According to the etiology, the risk factors can be divided into individual risk factors and occupational risk factors. Individual risk factors …

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Expression and correlation of Surfeit 4 gene in esophageal squamous cell carcinoma

Ting Lu, Jun Yang, Yu Jiang, Yan Zhao et autres

Abstract Backgroud In the previous era of functional genomics, it was widely believed that the expression levels of housekeeping genes (HKGs) remained relatively constant and were unaffected by variations in tissue type, cell development stage, cell cycle state, as well as internal …

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[Research progress on the mechanism of leucine regulation of protein synthesis in aging skeletal muscle through LAT1].

Yu Ke, Zhiqiang Dai, Ying Yang, Hui‐Wen Wu et autres

Age-related sarcopenia is a degenerative disease characterized by the decline in skeletal muscle mass and function during the aging process. Anabolic resistance, which refers to the diminished response of skeletal muscle to anabolic stimulation from leucine and other nutrients, is a significant …

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