N Matsubara

Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1

Hisano Yajima, Yuki Anraku, Yu Kaku, Kanako Kimura et autres

Since 2019, SARS-CoV-2 has undergone mutations, resulting in pandemic and epidemic waves. The SARS-CoV-2 spike protein, crucial for cellular entry, binds to the ACE2 receptor exclusively when its receptor-binding domain (RBD) adopts the up-conformation. However, whether ACE2 also interacts with the RBD …

jp, cz (code pays fourni par la source)

Molecular and structural insights into SARS-CoV-2 evolution: from BA.2 to XBB subvariants

Hisano Yajima, Tomo Nomai, Kaho Okumura, Katsumi Maenaka et autres

Due to the incessant emergence of various SARS-CoV-2 variants with enhanced fitness in the human population, controlling the COVID-19 pandemic has been challenging. Understanding how the virus enhances its fitness during a pandemic could offer valuable insights for more effective control of …

jp, cz (code pays fourni par la source)

Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236

Shigeru Fujita, Arnon Plianchaisuk, Sayaka Deguchi, Hayato Ito et autres

BACKGROUND: Although several SARS-CoV-2-related coronaviruses (SC2r-CoVs) were discovered in bats and pangolins, the differences in virological characteristics between SARS-CoV-2 and SC2r-CoVs remain poorly understood. Recently, BANAL-20-236 (B236) was isolated from a rectal swab of Malayan horseshoe bat and was found to lack …

jp, Égypte, hk, fr, ie (code pays fourni par la source)

Study of γ d → π + π − d Reaction in an Energy Region of 0.67 ≤ E γ ≤ 1.08 GeV

C. Kimura, Brian Beckford, T. Fujibayashi, Takao Fujii et autres

jp (code pays fourni par la source)

Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase

Futoshi Okada, Hiroshi Shionoya, Masanobu Kobayashi, T Kobayashi et autres

Weakly tumorigenic and nonmetastatic QR-32 cells derived from a fibrosarcoma in C57BL6 mouse are converted to malignant cells once they have grown after being coimplanted with a gelatine sponge which induces inflammation. We administered a newly developed peroral superoxide dismutase (SOD), oxykine, …

jp (code pays fourni par la source)

DNA gyrase gyrA mutations in quinolone-resistant clinical isolates of Staphylococcus haemolyticus

Minoru Yonezawa, Masahiro Takahata, N Banzawa-Futakuchi, N Matsubara et autres

DNA gyrase gyrA mutations in quinolone-resistant clinical isolates of Pseudomonas aeruginosa

Minoru Yonezawa, Masahiro Takahata, N Matsubara, Yasuo Watanabe et autres

The mutations in the quinolone resistance-determining region of the gyrA gene from clinical isolates of Pseudomonas aeruginosa were determined by DNA sequencing. The strains were isolated in 1989 and 1993. No mutations were detected in the clinical isolates in 1989, while five …

jp (code pays fourni par la source)

Secretion by Saccharomyces cerevisiae of rat apolipoprotein E as a fusion to Mucor rennin

Nobuhiko Nomura, Hisafumi Yamada, N Matsubara, Sueharu Horinouchi et autres

jp (code pays fourni par la source)

Secretion by Saccharomyces cerevisiae of rat apolipoprotein E as a fusion to Mucor rennin

Hiroshi Yamada, N Matsubara, S Horinouchi, Tomoe Beppu et autres

jp (code pays fourni par la source)

Nucleotide sequence of the malate dehydrogenase gene of Thermus flavus and its mutation directing an increase in enzyme activity.

Makoto Nishiyama, N Matsubara, Kazumi Yamamoto, Shinji Iijima et autres

The nucleotide sequence of the malate dehydrogenase (mdh) gene from a thermophilic bacterium, Thermus flavus, was determined. The amino acid sequence of the Thermus malate dehydrogenase resembled that of the porcine heart cytoplasmic enzyme to a certain extent, and Asp-159 and His-187 …

jp (code pays fourni par la source)

Antibacterial activity of cefoperazone alone and in combination against cephalosporinase-producing Enterobacter cloacae

Satoshi Minami, N Matsubara, A Yotsuji, Yasuo Watanabe et autres

The activity of cefoperazone against a strain with an inducible cephalosporinase and a mutant that produces the enzyme constitutively indicates that the low inducer activity of this antibiotic plays an important role in its activity against Enterobacter cloacae.

Kenya (code pays fourni par la source)

Immunological properties of beta-lactamases that hydrolyze cefuroxime and cefotaxime

Kanji Hirai, Kenichi Sato, N Matsubara, Ryoichi Katsumata et autres

Antiserum against purified beta-lactamase from Proteus vulgaris GN7919 cross-reacted with beta-lactamases produced by strains of Pseudomonas cepacia in a neutralization test. Anti-P. cepacia beta-lactamase serum, however, did not show any cross-reactions with P. vulgaris beta-lactamases. Each of these enzymes can hydrolyze cefuroxime …