Cangchang Shi

Multiomics analysis demonstrated that TOPBP1 interacting checkpoint and Replication Regulator may serve as an immune-related biomarker indicative of poor prognosis in lung adenocarcinoma

Chengbin Lin, Ziyi Chen, Wenbin Song, Long He et autres

Background Lung adenocarcinoma (LUAD) persists as a leading contributor to global cancer-associated mortality. Identifying key oncogenic drivers is crucial for improving therapeutic strategies. This study aimed to investigate the role of TICRR in LUAD progression and its potential as a therapeutic target. …

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Hypoxia- and lactate metabolism-associated prognostic and therapeutic signature in pancreatic cancer

Chenhui Zhang, Anqi Huang, Cangchang Shi, Zhijia Jiang et autres

BACKGROUND: Hypoxia and lactate metabolism products are critical components of the tumor microenvironment in pancreatic cancer (PC), influencing tumor invasiveness, metastasis, and treatment resistance. This study aims to explore the role of hypoxia- and lactate metabolism-related genes (HLRGs) in predicting overall survival …

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Identification of the role of MED6 in the development and prognosis of lung adenocarcinoma based on multi-omics profiling

Changqing Yang, Cheng Ding, Shuo Wang, Baichuan Wang et autres

Background: Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer.Recent studies have highlighted the importance of Mediator complex subunits in cancer, but their specific roles in LUAD are still unclear.Methods: The CRISPR-Cas9 loss-of-function data was used to assess gene dependency …

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Hypoxia- and Lactate Metabolism-Associated Prognostic and Therapeutic Signature in Pancreatic Cancer

Chenhui Zhang, Anqi Huang, Cangchang Shi, Zhijia Jiang et autres

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Integration of Single-Cell and Bulk Transcriptomes to Identify a Poor Prognostic Tumor Subgroup to Predict the Prognosis of Patients with Early-stage Lung Adenocarcinoma

Zijian Shi, Linchuang Jia, Baichuan Wang, Shuo Wang et autres

Our study provided a comprehensive characterization of the TME in LUAD through integrative single-cell and bulk transcriptomic analyses. We identified dynamic transitions from normal epithelial cells to tumor cells, revealing the heterogeneity and evolution of malignant LUAD cells. The novel prognostic model …

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Identification of the tumor metastasis-related tumor subgroups overexpressed NENF in triple-negative breast cancer by single-cell transcriptomics

Guixin Wang, Cangchang Shi, Long He, Yingxi Li et autres

Tumor metastasis is a continuous and dynamic process and is a major cause of tumor-related death in triple-negative breast cancer. However, this biological process remains largely unknown in triple-negative breast cancer. The emergence of single-cell sequencing enables a deeper understanding of the …

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