Mingyi Xia

Long-Term Outcomes of Patients With BRCA+ or PALB2+ Pancreatic Cancer Treated With Maintenance Rucaparib

Kim A. Reiss, Mingyi Xia, Mwangala P. Akamandisa, Kurt D’Andrea et autres

This secondary analysis of a nonrandomized clinical trial assesses long-term survival and genomic variants associated with therapeutic resistance in patients receiving maintenance rucaparib with BRCA1 , BRCA2 , or PALB2 germline or somatic pathogenic variants and platinum-sensitive metastatic pancreatic adenocarcinoma.

us, gb (code pays fourni par la source)

Comparative analysis of distinct genomic landscapes in young-onset gBRCA1/2 breast cancer

Mwangala P. Akamandisa, Mingyi Xia, Wilson Cheah, Bradley Wubbenhorst et autres

Carriers of germline BRCA1/2 pathogenic variants (gBRCA1/2 PVs) have elevated young-onset breast cancer risk. To define the pretreatment genomic landscapes of young-onset gBRCA-associated breast cancer, we evaluated 136 treatment-naive tumors diagnosed before age 50 in the prospective POSH study and 66 noncarriers …

us, gb (code pays fourni par la source)

Genomic profiling of young-onset g BRCA1/2 breast cancer reveals distinct genomic landscapes and therapeutic implications for PARP and CDK4/6 inhibitor selection

Mwangala P. Akamandisa, Mingyi Xia, Wilson Cheah, Bradley Wubbenhorst et autres

Abstract Purpose g BRCA1/2 pathogenic variant (PV) carriers have elevated young-onset breast cancer risk. Understanding the distinct genomic landscapes of g BRCA1- and g BRCA2 -associated breast cancer, including presence of PARP and CDK4/6 inhibitor (PARPi; CDK4/6i) response-associated alterations, may inform treatment …

us, gb (code pays fourni par la source)

Abstract 6596: Tumor molecular landscape and therapy implications in young BRCA1/2 carriers with breast cancer

Mwangala P. Akamandisa, Mingyi Xia, Wilson Cheah, Bradley Wubbenhorst et autres

Women with BRCA1/2 pathogenic variants (PVs) have a high likelihood of developing young onset breast cancer (BC) compared to noncarriers. In women enrolled in the POSH prospective cohort study of young women diagnosed with BC under age 40 or under age 50 …

us, gb (code pays fourni par la source)

Rap2B drives tumorigenesis and progression of colorectal cancer through intestinal cytoskeleton remodeling

Jiehui Di, Zhongjun Zhao, Mingyi Xia, Keyu Gao et autres

Ras family protein plays a key role in transducing signals involved in cytoskeletal remodeling and cell adhesion, which are particularly important in the development of colorectal cancer (CRC). While Rap2B, a member of the Ras superfamily, has been linked to cancer malignancy …

cn (code pays fourni par la source)

Nucleolin malonylation as a nuclear-cytosol signal exchange mechanism to drive cell proliferation in Hepatocarcinoma by enhancing AKT translation

Liang Sun, Hanjing Meng, Tao Liu, Qiong Zhao et autres

Cancer cells undergo metabolic reprogramming that is intricately linked to malignancy. Protein acylations are especially responsive to metabolic changes, influencing signal transduction pathways and fostering cell proliferation. However, as a novel type of acylations, the involvement of malonylation in cancer remains poorly …

cn, fr (code pays fourni par la source)

CPEB2 inhibit cell proliferation through upregulating p21 mRNA stability in glioma

Guang Zhao, Zhongjun Zhao, Mingyi Xia, Lishun Xiao et autres

Glioma is the most common primary malignant brain tumor in adults and remains an incurable disease at present. Thus, there is an urgent need for progress in finding novel molecular mechanisms that control the progression of glioma which could be used as …

cn (code pays fourni par la source)

Role of plectin and its interacting molecules in cancer

Keyu Gao, Zhimin Gao, Mingyi Xia, Hailong Li et autres

cn (code pays fourni par la source)