Zhimin Gao

π-conjugated molecule Y6 combined with an electron sacrificial agent boosts photodynamic therapy via enhanced glutathione photooxidation

Zhimin Gao, Qian Zhang, Ziyan Huang, Jin Feng et autres

The therapeutic efficacy of photodynamic therapy (PDT) is frequently severely compromised by the hypoxic tumor microenvironment (TME) and the robust antioxidative defense system mediated by overexpressed glutathione (GSH). While Type I PDT offers a potential solution to hypoxia, its performance remains limited …

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Optical coherence tomography findings in acute central retinal artery occlusion and their association with visual outcomes

Hao Wang, Hongyu Wei, Jieying Dong, Fen Zhang et autres

OBJECTIVES: This study aimed to summarize the optical coherence tomography (OCT) findings in central retinal artery occlusion (CRAO) and investigate their association with visual outcomes. METHOD: In this retrospective study, 63 cases (63 eyes) of CRAO were included. Clinical data, including age, …

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Rural Image Perception and Spatial Optimization Pathways Based on Social Media Data: A Case Study of Baishe Village—A Traditional Village

Zhimin Gao, Meng Jiao, Tongyu Jia, Chenyu Xu et autres

The sustainable development of traditional villages faces a core challenge stemming from the disconnect between public perception and spatial planning. To address this issue, this study, taking Baishe Village—a national-level traditional village—as a case study, constructs and applies a “Digital Humanities + …

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A tumor microenvironment-responsive nanocomposite for enhanced copper retention and hypoxia reversal to promote cuproptosis in tumor treatment

Wei Chen, Lin Chen, Zhimin Gao, Yongxin Huang et autres

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RAB7 protects against ischemic heart failure via promoting non-canonical TUFM mitophagy pathway

Yuling Sun, Wei Wang, Mingyan Li, Wen Guan et autres

We identify RAB7 as a novel coordinator of cardioprotective mitophagy through TUFM-mediated machinery assembly. The RAB7-TUFM axis represents a therapeutic target for IHF that warrants further clinical evaluation.

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NIR-activated endoplasmic reticulum stress amplifier to regulate phagocytosis for macrophage-mediated cancer immunotherapy

Yaru Zhang, Wenyu Xie, Jiamin Luo, Rui Zhen Gao et autres

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ATP‐Exhausted Strategy Induced Anti‐Tumor Low‐Temperature Photothermal Therapy Based on Rare Earth Nanocrystals Modified Hollow Porous MnO x Nanozyme with TME‐Activated NIR‐II Imaging

Xiaozhao Wang, Liqiang Jing, Zhengtao Luo, Zhimin Gao et autres

Abstract Insufficient adenosine triphosphate (ATP) can reduce the synthesis of heat‐stress‐induced heat shock proteins (HSPs) to promote the efficiency of mild photothermal therapy (mPTT), thus the rational design of ATP‐exhausted strategy based on nanotechnology is an effective approach to resuscitate mPTT. Herein, …

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MnO2@CeOx-GAMP radiosensitizer with oxygen vacancies depended mimicking enzyme-like activities for radiosensitization-mediated STING pathway activation

Meiling Tan, Zhimin Gao, Xinyi Wang, Xiaozhao Wang et autres

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Effect of water on CO2 capture and phase change in non-aqueous 1,4-butanediamine/ethylene glycol biphasic absorbents: Role of hydrogen bond competition

Cunshi Wang, Jianzhong Zhu, Gongkui Xiao, Xiaobin Zhou et autres

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Prediction the Wax Precipitation Characteristics in Waxy Crude Oil with Heavy Fraction Characterization

Qing Quan, Shouxi Wang, Zhimin Gao, Zhujun Liu

The calculation of component content distribution and related basic physical parameters in the heavy fraction of waxy oil will affect the calculation results of thermodynamic phase equilibrium and have an important impact on the prediction of the final wax precipitation characteristic parameters. …

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MnO2 nanozyme with lanthanide-based radiosensitization for advanced radiotherapy by tumor microenvironment triggering STING pathway activation

Meiling Tan, Zhimin Gao, Xiaozhao Wang, Lin Chen et autres

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Core–Shell Au@Pd Bimetallic Nanozyme Mediated Mild Photothermal Therapy through Reactive Oxygen Species-Regulating Tumor Thermoresistance

Yaru Zhang, Zhaocong Zheng, Zhankun Chen, Xiaozhao Wang et autres

Mild photothermal therapy (mPTT), which circumvents the limitations of conventional photothermal therapy, is emerging and exhibits remarkable potential in clinical applications. Nevertheless, mPTT is not able to efficiently eradicate tumors because its therapeutic efficacy is dramatically diminished by stress-induced heat shock proteins …

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