Sudharsan Sankar

Danio rerio as a Translational Model for Deciphering the Anti-Obesity Mechanisms of Orange Peel and Chili Extracts

Varshini Mahankali Bhavanandam, Sudharsan Sankar, K. Annadurai, Selvaraj Ramasamy et autres

Acute Effects of Size Dependent Low-Density Polyethylene Microplastics on Zebrafish

Sudharsan Sankar, Natarajan Chandrasekaran, Ajmitra Gurubaran, K. Rajagopal et autres

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Zebrafish and Drosophila as Model Systems for Studying the Impact of Microplastics and Nanoplastics ‐ A Systematic Review

Sudharsan Sankar, Natarajan Chandrasekaran, Meivelu Moovendhan‬‬‬‬‬‬‬‬, Venkatachalam Deepa Parvathi

ABSTRACT Microplastics and nanoplastics (MNPs) are byproducts of plastics created to benefit humanity, but improper disposal and inadequate recycling have turned them into a global menace that we can no longer conceal. As they interact with all living organisms, including humans, their …

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Flaxseed Oil, Casitose, and Its Combination Diets Increase Antioxidant Activity and Upregulates Aging-related Genes in Drosophila melanogaster

Indhuja Jayaraj, Vijaya Harini Sathyamurthy, Sudharsan Sankar, Selvaraj Ramasamy et autres

Abstract Background: Nutrigenomics refers to the study of how diet influences the genomic expression and function of an organism. Diet is a significant factor that impacts metabolism, aging, and lifespan. Long-term dietary patterns can influence the risk of age-related diseases, including diabetes, …

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Pharmacokinetic and pharmacodynamic modelling of the novel human granulocyte colony‐stimulating factor derivative Maxy‐G34 and pegfilgrastim in rats

Markus R. Scholz, Christoph Engel, Doris Apt, Sudharsan Sankar et autres

OBJECTIVES: This study aims to compare pharmacokinetics and pharmacodynamics of pegfilgrastim, a pharmaceutical recombinant human granulocyte colony-stimulating factor (rhG-CSF), with that of a newly developed reagent, Maxy-G34. This comparison was performed using rat experiments and biomathematical modelling of granulopoiesis. METHODS: Healthy rats …

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An open-label, dose-escalating study of Maxy-G34, a novel potent, long-acting Pegylated G-CSF, compared with pegfilgrastim (PF) for the treatment of chemotherapy induced neutropenia (CIN)

L. S. Schwartzberg, Sudharsan Sankar, Doris Apt, E. J. C. Goldstein et autres

e14500 Background: rhG-CSF reduces the incidence and duration of CIN in patients (pts) receiving myelosuppressive chemotherapy. Maxy-G34 is a recombinant, modified human G-CSF, containing three 5 kD PEG groups. These modifications alter both renal and receptor mediated clearance, leading to a longer …

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