Zebrafish and Drosophila as Model Systems for Studying the Impact of Microplastics and Nanoplastics ‐ A Systematic Review
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Le résumé fourni par la source
ABSTRACT Microplastics and nanoplastics (MNPs) are byproducts of plastics created to benefit humanity, but improper disposal and inadequate recycling have turned them into a global menace that we can no longer conceal. As they interact with all living organisms, including humans, their mechanism of interaction and their perilous impact must be meticulously investigated. To uncover the secrets of MNPs, there must be model systems that exist to interlink the two major scenarios: they must represent the environmental impact and be relevant to humans. Therefore, zebrafish and Drosophila are perfect to describe these two cases, as they are well studied and relatable to humans. In this review, 39% zebrafish studies reported higher mortality and hatching rates at greater MNP concentrations, severe oxidative stress as seen by raised malondialdehyde (MDA) levels, and reduced superoxide dismutase (SOD) activity. About 50% of studies showed severe neurotoxic behavior with drop of locomotor activity, suggesting neurotoxicity. MNPs have a significant impact on fertility rate of Drosophila . More than half of the studies revealed genotoxicity in Drosophila as observed by wing spot assays and modified genomic expressions associated with stress and detoxification processes. These findings emphasize the potential of MNPs to bioaccumulate, impair physiological systems, and cause oxidative and neurobehavioral damage. This study underscores the importance for thorough risk evaluations of MNPs and their environmental and health consequences.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Zebrafish and Drosophila as Model Systems for Studying the Impact of Microplastics and Nanoplastics ‐ A Systematic Review
- Date Crossref
- 28/12/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sri Ramachandra Institute of Higher Education and Research Department of Biomedical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Vellore Institute of Technology University pays non établi dans la noticeUniversité ou école supérieure
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Saveetha University pays non établi dans la noticeUniversité ou école supérieure
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Centre for Nanobiotechnology Vellore Institute of Technology (VIT) Vellore Tamil Nadu India pays non établi dans la noticeStructure de recherche
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Saveetha Medical College and Hospital Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai Tamil Nadu India Center for Global Health Research pays non établi dans la noticeUniversité ou école supérieure
Department of Biomedical Sciences — Sri Ramachandra Institute of Higher Education and Research, Vellore Institute of Technology University et Saveetha University, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.