Kathleen Zhang

Conditional Myeloid-Specific Inhibition of UBE2N Hinders YUMM1.7 Growth

Kelsie Schiavone, Adam Pecoraro, Afsa Khawar, Kathleen Zhang et autres

ABSTRACT The role of UBE2N in myeloid cell-mediated immune suppression in cancer remains undefined. Here, we examined the function of UBE2N in myeloid cell-mediated tumor progression using a temporally inducible myeloid-specific knockout model ( LysM CreER Ube2n fl/fl ). Temporally induced deletion …

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A human iPSC-derived motor neuron-myogenic cell coculture platform to evaluate neuromuscular junction innervation after axon injury and in Spinal Muscular Atrophy

Keunjung Heo, Xiangsunze Zeng, Kathleen Zhang, Kuchuan Chen et autres

SUMMARY Traumatic nerve injury is challenging as motor neurons with damaged axons repair slowly, which can lead to muscle degeneration, while in Spinal Muscular Atrophy (SMA), muscle innervation is reduced. While pro-regenerative or neuroprotective compounds have been identified, their specific ability to …

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Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration

Keunjung Heo, Tammy Szu‐Yu Ho, Xiangsunze Zeng, Bruna Lenfers Turnes et autres

Motor axon regeneration following peripheral nerve injury is critical for motor recovery but therapeutic interventions enhancing this are not available. We conduct a phenotypic screen on human motor neurons and identified blebbistatin, a non-muscle myosin II inhibitor, as the most effective neurite …

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Non-muscle Myosin Ii Inhibition at the Site of Axon Injury Increases Axon Regeneration

Clifford J. Woolf, Keunjung Heo, Tammy Szu‐Yu Ho, Xiangsunze Zeng et autres

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