Eduardo R. Zimmer

Astrocyte reactivity identifies p-tau217-positive individuals at elevated risk of cognitive decline across the Alzheimer’s disease continuum

Bruna Bellaver, Guilherme Povala, Pamela C. L. Ferreira, Douglas T. Leffa et autres

Abstract Background Plasma phosphorylated tau at threonine 217 (p-tau217) is a robust marker of Alzheimer’s disease (AD) pathology and progression. However, individuals positive for p-tau217 show substantial clinical heterogeneity, suggesting the influence of modifying biological processes. Here, we investigated whether plasma glial …

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Differential associations of tau extent and load with brain metabolic and cognitive dysfunction in Alzheimer's disease

Arthur C. Macedo, Lydia Trudel, Seyyed Ali Hosseini, Gleb Bezgin et autres

Background Reduced [ 18 F]Fluorodeoxyglucose ([ 18 F]FDG)-PET uptake is a core imaging feature of Alzheimer's disease (AD). While tau load correlates with this metabolic signature, it remains unclear whether the spatial extent of tauopathy (SEOT) more accurately explains brain glucose hypometabolic …

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Metabolic brain network reorganization precedes clinical conversion in Alzheimer’s disease

Christian Limberger, Guilherme Garcia Schu, Giordana Salvi de Souza, Marco Antônio De Bastiani et autres

Structured Abstract Introduction Brain glucose hypometabolism is a hallmark of Alzheimer’s disease (AD), yet conventional [ 18 F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) analyses have limited sensitivity in preclinical stages. Metabolic brain network approaches may better capture early vulnerability preceding clinical conversion. …

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The Microglia–Astrocyte–Neuron Lactate Shuttle model

Eduardo R. Zimmer, Anne‐Karine Bouzier‐Sore, Luc Pellerin

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Genome based subtyping identifies Parkinson’s disease subtypes with reproducible motor progression differences and clinical trial enrichment potential

Rafaela Ravazio, Daniel Teixeira-Dos-Santos, Christian Mattjie, Álvaro de Oliveira Franco et autres

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The Evolution of Randomized Clinical Trial Designs to Assess Therapeutics in Alzheimer Disease (P4-13.012)

Saman Arfaie, Étienne Aumont, Joseph Therriault, Angela Kwan et autres

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Tau extent outperforms tau load as a predictor of neurodegeneration in Alzheimer’s disease

Arthur C. Macedo, Lydia Trudel, Seyyed Ali Hosseini, Joseph Therriault et autres

BACKGROUND: In Alzheimer's disease (AD), tau pathology is more strongly linked to neurodegeneration than amyloid-β and better predicts brain atrophy. The spatial extent of tauopathy (SEOT) has shown promise as an earlier and more sensitive marker of AD severity than tau load, …

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Hypertension acts together with Aβ pathology in late-life to promote memory loss

L U Da Ros, João Pedro Ferrari‐Souza, Marco Antônio De Bastiani, Lucas Augusto Hauschild et autres

Midlife hypertension (HTN) contributes to cognitive decline in Alzheimer's disease (AD). However, the exact effect of late-life HTN on the AD pathology and on cognitive decline is still controversial. Here, we aimed to assess the impact of HTN and AD pathology in …

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Aβ‐ and tau‐associated neuroinflammatory signatures in Alzheimer's disease

Bruna Bellaver, Guilherme Povala, Marco Antônio De Bastiani, Ilaria Pola et autres

Abstract INTRODUCTION Neuroinflammation is increasingly recognized as a key contributor to Alzheimer's disease (AD) progression, with distinct responses linked to amyloid beta (Aβ) and tau pathology. Two detrimental waves of neuroinflammation have been proposed, the first during early Aβ accumulation, and the …

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Quality Gaps in Online Media Coverage of Antiamyloid Monoclonal Antibodies for Alzheimer Disease

Arthur C. Macedo, Albuquerque Lima, Isabela Sheng Ling Miaw, Isabella Harb Bizzi et autres

This cross-sectional study examines the quality of information on Alzheimer disease (AD) monoclonal antibodies presented by news websites.

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The landscape of dementia research, diagnosis, treatment, and care in Latin America

Claudia K. Suemoto, Nilton Custodio, Diego Alonso Gómez Aguilar, José A. Avila‐Funes et autres

Latin America is undergoing rapid population aging alongside a rising burden of dementia. While the region holds substantial potential for dementia risk reduction, challenges remain, such as delayed diagnoses, limited access to specialized care and biomarker testing, persistent stigma, and deep-rooted structural …

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Predictors of Successful Cognitive Aging in a Nationally Representative Brazilian Cohort (ELSI-Brazil)

Rhana Carolina Garcia Santos, Paulo Caramelli, Ricardo Nitríni, Natália Gomes Gonçalves et autres

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