Nilton Custodio

Plasma Biomarkers for the Diagnosis of Alzheimer’s Disease in Latin America: A Scoping Review Protocol

Laia Montoliu‐Gaya, Sheila Castro‐Suarez, Cender Udai Quispe-Juli, José Carlos Del Carmen Sara et autres

This scoping review aims to map and characterize the available evidence on the use, validation, clinical application, and implementation challenges of plasma biomarkers for the diagnosis of Alzheimer’s disease in Latin America. Alzheimer’s disease is a growing public health problem in the …

Plasma Biomarkers for the Diagnosis of Alzheimer’s Disease in Latin America: A Scoping Review Protocol

CARLOS A. NARVAEZ, Laura Baquedano, Naheli Mosquera Zevallos, Ana Daniela Saldarriaga Mayo et autres

This scoping review aims to map and characterize the available evidence on the use, validation, clinical application, and implementation challenges of plasma biomarkers for the diagnosis of Alzheimer’s disease in Latin America. Alzheimer’s disease is a growing public health problem in the …

Multidomain lifestyle intervention for the prevention of cognitive decline in at-risk older adults in Latin America (LatAm-FINGERS): a single-blind, multicentre, randomised controlled trial

Lucía Crivelli, Cláudia Kimie Suemoto, Ana Luisa Sosa, Francisco Lopera et autres

ar, us, mx, co, br, nl, uy, cl, do, cr, bo, pe, ec, pr, se (code pays fourni par la source)

Time to diagnosis in FTLD‐associated syndromes in Latin America

Nahuel Magrath Guimet, Florentina Morello García, Loana De Los Santos, Carolina Agata Ardohain-Cristalli et autres

INTRODUCTION: Frontotemporal lobar degeneration (FTLD) often affects younger patients, making time to diagnosis especially consequential. Most evidence comes from high-income countries, with limited data from Latin America. METHODS: We studied 415 individuals with FTLD-associated syndromes from 12 sites in six Latin American …

us, ar, co, ie, cl, mx, pe, br, tr, es (code pays fourni par la source)

Validity of the two different scoring methods of the Clinical Dementia Rating scale in staging and detection of cognitive impairment in the Peruvian population

Junior Senador, Rosa Montesinos, Belén Custodio, José Carlos Huilca et autres

INTRODUCTION: In Peru, the Global Deterioration Scale is the only available tool for assessing dementia severity. The Spanish translation and cultural adaptation of the Clinical Dementia Rating (CDR) is used locally but requires formal psychometric validation in the Peruvian sociocultural context. METHODS: …

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Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America

Temitope Farombi, Tiago Azzi, Agustina Legaz, David Aguillón et autres

INTRODUCTION: Adverse social conditions across the life course influence brain aging and dementia, yet their compounded impact on clinical phenotypes remains underexplored, particularly in Latin America, where social inequality and dementia burden are high. METHODS: We studied 3941 individuals from six Latin …

ie, Nigéria, nl, us, cl, ar, co, mx, pe, br, tr, es (code pays fourni par la source)

Mapping the neurovascular landscape in aging and dementia: cerebral small vessel disease markers in a multicenter Latin American cohort

Florencia Altschuler, Ana Maria Castro‐Laguardia, Verónica Canziani, Daniel Franco O'Byrne et autres

INTRODUCTION: Cerebral small vessel disease (CSVD) is a key contributor to cognitive impairment and dementia, yet few studies have compared CSVD across dementia variants, particularly in underrepresented populations. METHODS: In a multicenter cross-sectional study, we analyzed magnetic resonance imaging (MRI) markers of …

ar, cl, au, ie, us, pe, mx, co, br, tr, es (code pays fourni par la source)

Scalable biomarkers of Parkinson’s disease: insights from mobile EEG in Peru

Gregory Brown, Ludvik Alkhoury, Sudhin A. Shah, Andrew D. Krystal et autres

Mobile electroencephalography (EEG) may offer a scalable, cost-effective way to capture neural signatures of Parkinson’s disease (PD) in low-resource settings. In a cross-sectional cohort of 44 individuals with PD in Lima, Peru evaluated “off-medication”, we recorded EEG data using a 32-channel wireless …

us, pe (code pays fourni par la source)

Dementia screening protocol for primary care in South America: a Delphi consensus study

Belén Custodio, Rosa Montesinos, Paulo Caramelli, Ismael Calandri et autres

Introduction: Rapid population aging in South America (SA) highlights the need for effective dementia detection strategies. Primary care is essential for early identification, yet no shared, regionally contextualized approach exists. This study aimed to develop expert-based recommendations for dementia screening in SA …

pe, gb, br, ar, cl, cu (code pays fourni par la source)

A harmonized framework for studying exceptional cognitive aging in Latin America

Lucía Crivelli, Rodrigo Fernandez, Nicolas Corvalán, Ana Luisa Sosa et autres

INTRODUCTION: Biological, genetic, and sociocultural factors underlying cognitive resilience and resistance to pathology remain unexplored in Latin America. The Life-Course Epidemiology of Aging, Resilience, and Neurodegeneration in Alzheimer's Disease (LEARN-AD) study and Latin American SuperAgers Study (LASAS) establish the first harmonized frameworks …

ar, mx, do, br, co, cl, pe, uy, cu, gb, us (code pays fourni par la source)

Neural embedding of frailty in cognitively unimpaired aging and dementia across Latin America

Joaquín Migeot, Olivia Wen, Raul Gonzalez‐Gomez, Hernan Hernandez et autres

INTRODUCTION: Frailty influences dementia risk and severity. However, its role in differentiating dementia subtypes and associations with brain structural and functional alterations remain understudied, especially in Latin America. METHODS: Multi-Partner Consortium to Expand Dementia Research in Latin America data included 3461 participants …

ie, cl, co, fr, mx, ar, pe, us, br, tr, es (code pays fourni par la source)

The exposome of brain aging across 34 countries

Agustina Legaz, Sebastián Moguilner, Pablo Barttfeld, Jhosmary Cuadros Castro et autres

The physical and social exposome affects human aging, and brain clocks may track its effects. However, most studies neglect multidomain exposures (physical, social and political) across diverse settings globally and their associations with brain aging. In this study, we characterized the associations …