Qingyan Mo

Modulatory effects of traditional Chinese medicine and derived active metabolites on autoimmune-inflammatory signaling pathways in multiple sclerosis: a narrative review

Die Qian, Xiaohong Li, Jingjing Ge, Shuai Liu et autres

Multiple sclerosis (MS), an immune-mediated neuroinflammatory disease, is characterized by demyelination, axonal injury and extensive destruction of the integrity of the central nervous system. Experimental autoimmune encephalomyelitis (EAE) is the most commonly used model for simulating the pathological features of human MS. …

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Advancements in understanding and treating CXCL16/CXCR6 in tumors and in inflammatory diseases: a narrative review

Xiaohong Li, S J Liu, Die Qian, Maokui Huang et autres

The CXCL16/CXCR6 axis exerts a multifaceted, bidirectional regulatory influence across various pathological processes, including neoplasms and inflammatory disorders. Its functions are notably context-dependent, possessing the capacity to both inhibit and facilitate disease progression. This article aims to systematically analyze this 'double-edged sword' …

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CXCR6 as a novel therapeutic target in allergic asthma

Nanting Zou, Xiaodong Yan, Zhao Wu, Qingyan Mo et autres

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Immunogenicity and safety of the booster COVID-19 vaccine among people with HIV: a systematic review and meta-analysis

Zhenzhen Chen, Chunping Wan, Bing Chen, Qingyan Mo et autres

Background Human immunodeficiency virus (HIV) and COVID-19 continue to pose significant global public health challenges. Although vaccination is essential for preventing COVID-19 in people with HIV (PWH), evidence on the immunogenicity and safety of booster doses remains limited. This systematic review aimed …

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MW ‐19, a dihydropyrazole derivative, induces human triple‐negative breast cancer cell apoptosis by targeting apoptosis‐related pathways

Nanting Zou, Runfang Wu, Zhao Wu, Chunfei Zhang et autres

Previous studies have indicated that heterocyclic substituted dihydropyrazole derivatives, particularly MW-19, potentially exert anticancer activity in vitro; however, the underlying mechanism remains unknown. The present study was designed to investigate the mechanisms underlying MW-19 activity in triple-negative breast cancer cells. A sulforhodamine …

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A third (booster) dose of the inactivated SARS-CoV-2 vaccine elicits immunogenicity and T follicular helper cell responses in people living with HIV

Zhengchao Lv, Songqin Lv, Qin Li, Yafei Xia et autres

Introduction: This study sought to explore the immunogenicity of a booster dose of an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine in people living with human immunodeficiency virus (HIV) and identify the factors affecting the magnitude of anti-SARS-CoV-2 antibody levels. …

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