Bing Chen

Gut microbiota reconstruction after liver transplantation and its association with early postoperative infections in patients with liver failure

Bing Chen, Jun Chen, Zhangpeng Feng, Hanbei Lv et autres

Background Postoperative infection remains a major cause of morbidity after liver transplantation (LT) in patients with liver failure. Increasing evidence suggests that gut microbiota dysbiosis may contribute to infection risk, but its dynamic changes after LT are not fully understood. Methods This …

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Influence of Genetic Polymorphisms on Tacrolimus Pharmacokinetics in Whole Blood, Plasma, and Peripheral Blood Mononuclear Cells in Chinese Kidney Allograft Recipients

Yun-Zhu Lu, Xiao-Ling Lu, Yu‐Ping Wang, Jia‐Qian Lu et autres

BACKGROUND: Significant variations in tacrolimus (TAC) pharmacokinetics (PK) occur across whole blood, plasma, and peripheral blood mononuclear cells (PBMCs). In the present study, TAC plasma levels were estimated based on TAC whole blood levels, and the influence of genetic polymorphisms on the …

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Endoscopic resection of adult sphenoid sinus myofibroma: a rare case report with narrative review

Chong Zhang, Zhipeng Wu, Bing Chen, Yuyang Zhao et autres

This study documents an exceptionally rare instance of primary myofibroma originating in the sphenoid sinus of a 60-year-old female patient, who presented with acute progressive diplopia, ptosis, and headache. Preoperative imaging identified a hypervascular lesion within the sphenoid sinus, accompanied by significant …

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Tannins: A Promising Antidote to Mitigate the Harmful Effects of Aflatoxin B1 to Animals

Wenhao Sun, Ruiqi Dong, Guoxia WANG, Bing Chen et autres

Aflatoxin B1 (AFB1), a major metabolite of aflatoxin, is a highly toxic carcinogen. It frequently contaminates feed due to improper storage of feed ingredients such as corn and peanut meal, with the contamination risk further escalating alongside the increasing incorporation of plant-based …

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Integrated bioinformatics and pharmacology reveal esculin’s mechanism against pancreatic adenocarcinoma drug resistance

Jiapu Wang, Hang Gao, Bing Chen, Qi Liu et autres

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Pharmacokinetics of mycophenolic acid in plasma and peripheral blood mononuclear cells and its relationship with activity of inosine monophosphate dehydrogenase in Chinese adult kidney allograft recipients

Ying Lu, Xiaoling Lu, Jia‐Qian Lu, Kun Shao et autres

Aims We aimed to study the pharmacokinetics (PK) of mycophenolic acid (MPA) in plasma and peripheral blood mononuclear cells (PBMCs) and the relationship of MPA in plasma and PBMC with activity of inosine monophosphate dehydrogenase (IMPDH) in Chinese kidney allograft recipients. Methods …

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Immunogenicity and safety of the booster COVID-19 vaccine among people with HIV: a systematic review and meta-analysis

Zhenzhen Chen, Chunping Wan, Bing Chen, Qingyan Mo et autres

Background Human immunodeficiency virus (HIV) and COVID-19 continue to pose significant global public health challenges. Although vaccination is essential for preventing COVID-19 in people with HIV (PWH), evidence on the immunogenicity and safety of booster doses remains limited. This systematic review aimed …

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Investigating Hippocampal Microstructural Differences in Temporal Lobe Epilepsy Patients with Cognitive Impairment Using NODDI

Wenrui Yang, Yuhui Xiong, H. Ye, Bing Chen

Motivation: Temporal lobe epilepsy (TLE) significantly impacts patients' quality of life, with cognitive impairment (CI) being a common comorbidity. Understanding hippocampal microstructure changes is crucial for diagnosing TLE and its associated CI. Goal(s): To investigate hippocampal microstructure differences between TLE patients with …

Simultaneous Measurement of Mycophenolic Acid with Other Immunosuppressants in Whole Blood and Plasma by Using Liquid Chromatography–Tandem Mass Spectrometry

Yuping Wang, Xiaohui Zhai, Xi‐Han Wang, Kun Shao et autres

Therapeutic drug monitoring (TDM) of immunosuppressive drugs (ISDs) is essential for transplant recipients. The aim of this study is to establish an LC-MS/MS method to determine mycophenolic acid (MPA) and its metabolite, cyclosporin A (CsA), tacrolimus (TAC) and sirolimus (SRL) levels in …

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A parallel computing-in-memory accelerator utilizing FeRAM array with retention loss correction

Can Liu, Zhihao Shen, Bo Li, Xiaomeng Lv et autres

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Impact of Brain Frailty on Clinical Presentation and Neurologic Recovery in Acute Ischemic Stroke Patients Undergoing Thrombectomy

Joachim Fladt, Faysal Benali, Tanaporn Jaroenngarmsamer, Fouzi Bala et autres

Background and ObjectivesBrain frailty impairs the ability to compensate for brain dysfunction and is linked to worse outcomes after stroke. Stroke severity at presentation is a key determinant of outcomes in acute ischemic stroke. This study aimed to examine the impact of …

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Immunoglobulin G N-Glycome as a biomarker of mortality risk in Escherichia coli induced sepsis

Huachen Wang, Houqiang Li, Zheng Guo, Hongda Hou et autres

Background Sepsis is a life-threatening syndrome caused by an imbalance in the inflammatory response to an infection that can lead to a high mortality rate. Escherichia coli is a common pathogen that causes sepsis. The role of immunoglobulin G N-glycome in estimating …

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