Sicong Yue

The combination of P4 and FSH promotes the formation of small antral follicles by up-regulating FSHR and CYP19A1 in Hu Sheep at the late luteal phase

Chunhui Duan, Xuejiao Yin, Yuchun Xie, Zhipan Song et autres

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miR-17-5p-Mediated RNA Activation Upregulates KPNA2 Expression and Inhibits High-Glucose-Induced Apoptosis of Sheep Granulosa Cells

Yong Wang, Feng Tian, Sicong Yue, Jiuyue Li et autres

The glucose metabolism homeostasis in the follicular fluid microenvironment plays an important role in follicular maturation and ovulation, and excessively high or low glucose concentrations have adverse effects on the differentiation of follicular granulosa cells (GCs). However, a limited number of microRNAs …

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Identification of Novel 58-5p and SREBF1 Interaction and Effects on Apoptosis of Ovine Ovarian Granulosa Cell

Ruochen Yang, Yong Wang, Sicong Yue, Yueqin Liu et autres

High concentrations of prolactin (PRL)-induced ovine ovarian granulosa cell (GCs) apoptosis and MAPK12 could aggravate the induced effect. However, the molecular mechanisms that MAPK12-induced GC apoptosis and repressed steroid hormone secretion remain unclear. In this study, GCs in the P group (GCs …

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Prolactin Inhibition Promotes Follicle Recruitment by Increasing PIKfyve Expression in Ewes During the Estrus Stage

Sicong Yue, Chunhui Duan, Yong Wang, Xiangyun Li et autres

Prolactin (PRL) plays a key role in the growth and ovulation of animal follicles, but its impact on follicular recruitment in ewes remains uncertain. In this study, a total of sixteen healthy ewes (Hu sheep, aged 2–3 years, with continuous reproduction and …

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Energy Metabolite, Immunity, Antioxidant Capacity, and Rumen Microbiota Differences Between Ewes in Late Gestation Carrying Single, Twin, and Triplet Fetuses

Jiaxin Chen, Chunhui Duan, Sicong Yue, Xiaona Liu et autres

The objective of this study was to investigate the differences in the energy metabolites, immunity, antioxidant capacity, and rumen microbiota of ewes with different numbers of fetuses. Thirty healthy ewes were selected and divided into single- (SL, n = 10), twin- (TL, …

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The Effect of Prolactin on Gene Expression and the Secretion of Reproductive Hormones in Ewes during the Estrus Cycle

Sicong Yue, Jiaxin Chen, Chunhui Duan, Xiangyun Li et autres

Prolactin (PRL) plays an important role in animal follicle development and ovulation. However, its regulatory effects on the different stages of the estrus cycle in ewes are unclear. In this study, bromocriptine (BCR, PRL inhibitor) was used to study the effect of …

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Prolactin inhibitor changes testosterone production, testicular morphology, and related genes expression in cashmere goats

Meijing Chen, Chunhui Duan, Xuejiao Yin, Xianglong Li et autres

Prolactin has multifaceted roles in lactation, growth, metabolism, osmoregulation, behavior, and the reproduction of animals. This study aimed to investigate the involvement of prolactin in testicular function in cashmere goats. Twenty cashmere goats were randomly assigned to either the control group (CON) …

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High Prolactin Concentration Induces Ovarian Granulosa Cell Oxidative Stress, Leading to Apoptosis Mediated by L-PRLR and S-PRLR

Ruochen Yang, Chunhui Duan, Shuo Zhang, Yunxia Guo et autres

High prolactin (PRL) concentration has been shown to induce the apoptosis of ovine ovarian granulosa cells (GCs), but the underlying mechanisms are unclear. This study aimed to investigate the mechanism of apoptosis induced by high PRL concentration in GCs. Trial 1: The …

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Effect of prolactin on cytotoxicity and oxidative stress in ovine ovarian granulosa cells

Ruochen Yang, Shuo Zhang, Chunhui Duan, Yunxia Guo et autres

Background: Prolactin (PRL) has been reported to be associated with oxidative stress, which is an important contributor leading to cell apoptosis. However, little is known about the mechanisms underlying the effects of PRL on cytotoxicity and oxidative stress in ovine ovarian granulosa …

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