Luca Branca

Procedural and Hemodynamic Outcomes of Contemporary Self-Expanding Valves for Transcatheter Aortic Valve Replacement: A Multicenter Comparison from the AMTRAC registry

Amos Levi, Yeela Talmor-Barkan, Marco Barbanti, Sofia Sammartino et autres

Background Comparative data among contemporary self-expanding transcatheter heart valve designs remain limited. We compared clinical and hemodynamic outcomes following transcatheter aortic valve replacement (TAVR) using two leading contemporary platforms. Methods This multicenter cohort study utilized the AMTRAC registry to evaluate consecutive patients …

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Real-World Comparison of Balloon-Expandable Valves for Transcatheter Aortic Valve Replacement: Data From the Aortic+Mitral TRAansCatheter Valve Registry

Yeela Talmor-Barkan, Kush Patel, Marco Barbanti, Sofia Sammartino et autres

Background Comparative real-world data on newer balloon-expandable valve (BEV) platforms remain limited. We sought to compare clinical, procedural, and early hemodynamic outcomes following transcatheter aortic valve replacement (TAVR) using 2 contemporary balloon-expandable valves in a multicenter international registry. Methods Consecutive patients undergoing …

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Long-term durability of self-expandable transcatheter heart valves in bicuspid versus tricuspid aortic valve stenosis: a matched-cohort analysis

Mauro Massussi, Nicola Cristiano, Giuliano Chizzola, Claudia Fiorina et autres

BACKGROUND: A bicuspid aortic valve (BAV) presents unique challenges for transcatheter aortic valve implantation (TAVI), and evidence on long-term bioprosthetic durability in an BAV compared to a tricuspid aortic valve (TAV) remains limited. We aimed to compare the 5-year durability and hemodynamic …

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Aortic Valve Calcium Score Spectrum Identifies Bimodal Outcomes for Transcatheter Aortic Valve Implantation: Insights From the AMTRAC Registry

Yeela Talmor‐Barkan, Marco Barbanti, Roberto Valvo, Giuliano Costa et autres

Background Degenerative calcification is the primary mechanism underlying severe aortic stenosis; however, some patients with hemodynamically severe aortic stenosis have low aortic valve calcium scores (AVCS), suggesting heterogeneous disease processes. This study aimed to evaluate the clinical characteristics and outcomes across the …

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Heart Failure and Moderate Aortic Stenosis: is Early TAVI the Better Strategy?

Michele Legati, Luca Branca, Angelica Cersosimo, Marianna Adamo

Aortic stenosis (AS) is the most common valvular heart disease in Western countries. Current clinical guidelines recommend intervention exclusively for severe AS, given its association with poor short-term prognosis. However, accumulating evidence over recent years suggests that even moderate AS may be …

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Impact of unfavorable aortic anatomy on transcatheter aortic valve replacement outcomes

Sofia Sammartino, Giulia Laterra, Francesco Saia, Thomas Pilgrim et autres

BACKGROUND: Despite device improvements for transcatheter aortic valve replacement (TAVR) and increased operator expertise, unfavorable aortic root anatomy might subtend worse procedural and clinical outcomes. The aim of the study is to assess procedural and clinical outcomes of transfemoral TAVR in patients …

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Sex differences in hemodynamics and outcomes after transcatheter aortic valve replacement

Henning Guthoff, Mohamed Abdel-Waha, Won‐Keun Kim, Hendrik Wienemann et autres

Abstract Background Women remain underrepresented in transcatheter aortic valve replacement (TAVR) trials, despite well-recognized anatomical differences that necessitate tailored procedural strategies. This study assessed sex-specific differences in baseline characteristics, procedural approaches, hemodynamic outcomes, and their impact on 5-year all-cause mortality. Methods We …

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Secondary access and routine protection wire for transfemoral transcatheter aortic valve replacement: the SURF-TAVR registry

Ottavia Cozzi, P Ratan, Giulia Costa, Luca Branca et autres

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The impact of contractile reserve on clinical outcomes in patients with left ventricular dysfunction undergoing TAVI

Yeela Talmor‐Barkan, Amos Levi, Marco Barbanti, Roberto Valvo et autres

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Eight-month angiographic outcomes and in-stent restenosis in patients undergoing percutaneous coronary intervention on unprotected left main coronary artery

Mauro Massussi, Andrea Drera, Edoardo Pancaldi, Elisa Pezzola et autres

In-stent restenosis (ISR) remains a significant complication of percutaneous coronary intervention (PCI) for left main coronary artery (LMCA) disease, with potentially severe consequences. This study aimed to evaluate the incidence and predictors of ISR and highlight the role of systematic angiographic follow-up …

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Impact of Measured and Predicted Prosthesis-Patient Mismatch After Transcatheter Aortic Valve Replacement

Henning Guthoff, Mohamed Abdel‐Wahab, Won‐Keun Kim, Guy Witberg et autres

BACKGROUND: Prosthesis-patient mismatch after transcatheter aortic valve replacement (TAVR) can be measured echocardiographically (measured prosthesis-patient mismatch [PPMm]) or predicted (predicted prosthesis-patient mismatch [PPMp]) using published effective orifice area (EOA) reference values. However, the clinical implications of PPM post-TAVR remain unclear. OBJECTIVES: This …

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Left Atrial Appendage Occlusion vs Standard of Care After Ischemic Stroke Despite Anticoagulation

Moniek Maarse, David Seiffge, David J. Werring, Lucas V.A. Boersma et autres

Importance: Patients with atrial fibrillation (AF) who have ischemic stroke despite taking oral anticoagulation therapy (OAT) have a very high risk of recurrence. Left atrial appendage occlusion (LAAO) is a mechanical stroke prevention strategy that may provide additional protection in patients with …

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