Mehrdad Jafari

Transanal Endoscopic Microsurgery or Endoscopic Submucosal Dissection in Early Rectal Tumors: A Clinical and Cost-Effectiveness Analysis: The MUCEM Study

Laura Beyer-Berjot, Coralie Delettrez, Jérémie Jacques, Philippe Rouanet et autres

BACKGROUND & AIMS: For the local excision of early rectal tumors (ERTs), the relative effectiveness of endoscopic submucosal dissection (ESD) vs transanal endoscopic microsurgery (TEM) is subject to debate. The comparisons are limited to retrospective, single-center studies lacking a health economic assessment. …

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4297 Chemotherapy and reirradiation vs chemotherapy as preoperative treatment for recurrent rectal cancer: the GRECCAR15 randomized trial (NCT03879109)

Véronique Vendrely, Laurent Ghouti, Philippe Rouanet, Adeline Germain et autres

Final Results of the GRECCAR-6 Trial on Waiting Period Following Neoadjuvant Radiochemotherapy for Locally Advanced Rectal Cancer: 5 Years of Follow-up

M. Collard, Laurent Mineur, Célia Nekrouf, Quentin Denost et autres

BACKGROUND: The potential oncological benefit of extending the waiting period between neoadjuvant radiochemotherapy and surgical resection for rectal cancer is debated. OBJECTIVE: To evaluate the impact of prolonging this waiting period on the 5-year oncological prognosis and 2-year functional result of locally …

fr, ca (code pays fourni par la source)

Improved Metastatic-Free Survival after Systematic Re-Excision Following Complete Macroscopic Unplanned Excision of Limb or Trunk Soft Tissue Sarcoma

F. Gouin, Audrey Michot, Mehrdad Jafari, Charles Honoré et autres

Background: Whether re-excision (RE) of a soft tissue sarcoma (STS) of limb or trunk should be systematized as adjuvant care and if it would improve metastatic free survival (MFS) are still debated. The impact of resection margins after unplanned macroscopically complete excision …

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Overall survival in patients with re-excision of positive microscopic margins of limb and trunk wall soft tissue sarcoma operated outside of a reference center: a nationwide cohort analysis

F. Gouin, Eberhard Stoeckle, Charles Honoré, M. Ropars et autres

BACKGROUND: This French nationwide NETSARC exhaustive prospective cohort aims to explore the impact of systematic re-excision (RE) as adjuvant care on overall survival (OS), local recurrence free survival (LRFS), and local and distant control (RFS) in patients with soft tissue sarcoma (STS) …

fr, re (code pays fourni par la source)

End Colostomy With or Without Mesh to Prevent a Parastomal Hernia (GRECCAR 7): A Prospective, Randomized, Double Blinded, Multicentre Trial.

Michel Prudhomme, Éric Rullier, Zaher Lakkis, Eddy Cotte et autres

OBJECTIVE: To evaluate whether systematic mesh implantation upon primary colostomy creation was effective to prevent PSH. SUMMARY OF BACKGROUND DATA: Previous randomized trials on prevention of PSH by mesh placement have shown contradictory results. METHODS: This was a prospective, randomized controlled trial …

fr (code pays fourni par la source)

Early and late morbidity of local excision after chemoradiotherapy for rectal cancer

Blanche TESTE, Philippe Rouanet, Jean‐Jacques Tuech, A. Valverde et autres

BACKGROUND: Local excision (LE) after chemoradiotherapy is a new option in low rectal cancer, but morbidity has never been compared prospectively with total mesorectal excision (TME). Early and late morbidity were compared in patients treated either by LE or TME after neoadjuvant …

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Sphincter-saving surgery after neoadjuvant therapy for ultra-low rectal cancer where abdominoperineal resection was indicated: 10-year results of the GRECCAR 1 trial

Philippe Rouanet, Michel Rivoire, Sophie Gourgou, Bernard Lelong et autres

This phase III trial included patients with ultra-low rectal adenocarcinoma that initially required abdominoperineal resection. The surgical decision was based on clinical tumour status after preoperative treatment. The overall sphincter-saving resection rate was 85 per cent, with 72 per cent rate of …

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End Colostomy With or Without Mesh to Prevent a Parastomal Hernia (GRECCAR 7)

Michel Prudhomme, Éric Rullier, Zaher Lakkis, Eddy Cotte et autres

Objective: To evaluate whether systematic mesh implantation upon primary colostomy creation was effective to prevent PSH. Summary of Background Data: Previous randomized trials on prevention of PSH by mesh placement have shown contradictory results. Methods: This was a prospective, randomized controlled trial …

fr (code pays fourni par la source)

International variation in managing locally advanced or recurrent rectal cancer: prospective benchmark analysis

Quentin Denost, Michael J. Solomon, J-J Tuech, Laurent Ghouti et autres

BACKGROUND: Tumour extension beyond the mesorectal plane (ymrT4) occurs in 5-10 per cent of patients with rectal cancer and 10 per cent of patients develop locally recurrent rectal cancer (LRRC) after primary surgery. There is global variation in healthcare delivery for these …

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Organ preservation with chemoradiotherapy plus local excision for rectal cancer: 5-year results of the GRECCAR 2 randomised trial

Éric Rullier, V. Vendrely, Julien Asselineau, Philippe Rouanet et autres

fr (code pays fourni par la source)

Does A Longer Waiting Period After Neoadjuvant Radio-chemotherapy Improve the Oncological Prognosis of Rectal Cancer?

Jérémie H. Lefèvre, Laurent Mineur, Marine Cachanado, Quentin Denost et autres

OBJECTIVE: The aim of this study was to report the 3-year survival results of the GRECCAR-6 trial. SUMMARY BACKGROUND DATA: Current data on the effect of an extended interval between radiochemotherapy (RCT) and resection for rectal cancer on the rate of complete …

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