Kailiang Qiao

Innate immune sensing via the cGAS-STING pathway restricts extrachromosomal DNA–driven tumorigenesis

Tuo Li, Qinglin Yang, Kailiang Qiao, Anli Zhang et autres

Summary Extrachromosomal DNAs (ecDNAs) are circular DNA fragments frequently found in human cancers, where they amplify oncogenes, drive tumor heterogeneity, and promote therapy resistance and poor prognosis. Despite their prevalence, how ecDNAs interact with the immune system remains poorly understood. Here, we …

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Retraction Note: Polyphyllin I suppresses the formation of vasculogenic mimicry via Twist1/VE-cadherin pathway

Ting Xiao, Weilong Zhong, Jianmin Zhao, Baoxin Qian et autres

The Editors-in-Chief have retracted this article. A number of image integrity issues were raised after publication. Specifically: Two panels representing different conditions in figure 2A appear to be duplicated with frameshift Two PLC panels in supplementary figure 3B appear to be duplicated …

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ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment

Kailiang Qiao, Qing‐Lin Yang, Tuo Li, Xiongfeng Chen et autres

Abstract ecDNA contributes to cancer genetic heterogeneity through random segregation during mitosis. Emerging evidence links ecDNA to immune evasion, but the mechanism remains elusive. Using genetically engineered mouse models of pancreatic ductal adenocarcinoma (PDAC), we show that Kras and Myc oncogenes are …

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Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches

Xiongfeng Chen, Zhuan Zhou, Luyu Xie, Kailiang Qiao et autres

Recent studies identify a unique subtype of cancer-associated fibroblasts (CAFs) termed antigen-presenting CAFs (apCAFs), which remain poorly understood. To gain a comprehensive understanding of the origin and function of apCAFs, we construct a fibroblast molecular atlas across 15 types of tissues and …

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Intratumor Mycoplasma promotes the initiation and progression of hepatocellular carcinoma

Kailiang Qiao, Jingxia Han, Haohao Zhang, Yinan Li et autres

Modern biology of extrachromosomal DNA: A decade-long voyage of discovery

Qinglin Yang, Kailiang Qiao, Jun Yi Stanley Lim, Sihan Wu

Genomic instability is a hallmark of cancer and is a major driving force of tumorigenesis. A key manifestation of genomic instability is the formation of extrachromosomal DNAs (ecDNAs) - acentric, circular DNA molecules ranging from 50 kb to 5 Mb in size, …

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Corrigendum to “Salidroside improves the hypoxic tumor microenvironment and reverses the drug resistance of platinum drugs via HIF-1α signaling pathway” [EBioMedicine 38 (2018) 25–36]

Yuan Qin, Huijuan Liu, Meng Li, Denghui Zhai et autres

The authors regret that the representative pictures in Figure 4A/C, 5E/G were incorrectly presented in the published version of this article. Due to similar research objectives (platinum chemotherapy induced resistance and epithelial–mesenchymal transition), grouping and naming methods with another study being conducted …

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Intratumor Mycoplasma promotes the initiation and progression of hepatocellular carcinoma

Kailiang Qiao, Jingxia Han, Haohao Zhang, Yinan Li et autres

The carcinogenesis and progression of hepatocellular carcinoma (HCC) are closely related to viral infection and intestinal bacteria. However, little is known about bacteria within the HCC tumor microenvironment. Here, we showed that intratumoral Mycoplasma hyorhinis (M. hyorhinis) promoted the initiation and progression …

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Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor

Yinan Li, Kailiang Qiao, Xiaoyun Zhang, Haoyang Liu et autres

(iScience 24, 103392, December 17, 2021) During the figure preparation for this article, the wrong first panel in Figure 2C was inadvertently presented. This has now been corrected online. The authors regret this error and apologize for any confusion that it has …

Correction: RNA m6A methylation promotes the formation of vasculogenic mimicry in hepatocellular carcinoma via Hippo pathway

Kailiang Qiao, Yantao Liu, Zheng Gang Xu, Haohao Zhang et autres

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Biomimetic Immunosuppressive Exosomes that Inhibit Cytokine Storms Contribute to the Alleviation of Sepsis (Adv. Mater. 19/2022)

Yinan Li, Heng Zhang, Caihong Chen, Kailiang Qiao et autres

Cytokine Storms The homeostasis of the body is regulated by the immune system. The balance between tumorinduced immunosuppressive states and cytokine storms caused by immune hyperactivation in sepsis is like the yin and yang in Chinese. Biomimetic exosomes can suppress cytokine storms …

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Biomimetic Immunosuppressive Exosomes that Inhibit Cytokine Storms Contribute to the Alleviation of Sepsis

Yinan Li, Heng Zhang, Caihong Chen, Kailiang Qiao et autres

Sepsis is a disease characterized by multiple organ failure caused by immune hyperactivation and cytokine storms. Studies have shown that the incidence of sepsis in melanoma patients is substantially lower compared to the general population. It is also observed that experimental tumor-bearing …

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